Results 31 to 40 of about 18,005 (233)

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance [PDF]

, 2019
Recent studies implicate a strong association between elevated plasma branched-chain amino acids (BCAAs) and insulin resistance (IR). However, a causal relationship and whether interrupted BCAA homeostasis can serve as a therapeutic target for diabetes ...
Liu, Yunxia, Wang, Ji, Qi, Xiangbing, Sun, Haipeng, Lusis, Aldons J, Gui, Wen-Jun, Shu, Le, Wang, Weiqing, Shao, Jing, Yang, Xia, Wang, Yibin, Zhou, Meiyi, Wu, Cheng-Yang, Chen, Mengping, Dong, Weibing, Wynn, R Max, Wang, Jiqiu, Chuang, David T, Li, Zhaoping, Ning, Guang   +19 more
core   +1 more source

Exercise Enhances Branched-Chain Amino Acid Catabolism and Decreases Cardiac Vulnerability to Myocardial Ischemic Injury

Cells, 2022
Long-term exercise-induced metabolic adaptations occupy a central position in exercise-afforded cardiac benefits. Emerging evidence suggests that branched-chain amino acid (BCAA) catabolic defect contributes to cardiac dysfunction in multiple ...
Guiling Wu, Yanjie Guo, Min Li, Chenhan Li, Yanzhen Tan, Yueyang Li, Jia Li, Li Wang, Xing Zhang, Feng Gao   +9 more
doaj   +1 more source

The role and metabolic functions of the branched-chain amino acids: a review [PDF]

E3S Web of Conferences, 2022
In recent years, a number of new functions of branched-chain amino acids (BCAA) - leucine, valine and isoleucine - have been revealed in various states of the body in animals and humans.
Obvintseva Olga, Erimbetov Kenes, Mikhailov Vitaly, Sofronova Olga, Polyakova Lyudmila   +4 more
doaj   +1 more source

The Effects of BCAAs on Insulin Resistance in Athletes

Journal of Nutritional Science and Vitaminology, 2019
The toxic catabolic intermediates of branched chain amino acids can cause insulin resistance, and are involved in different mechanisms in different metabolic tissues. In skeletal muscle, 3-hydroxy-isobutyrate produced by valine promotes skeletal muscle fatty acid uptake, resulting in the accumulation of incompletely oxidized lipids in skeletal muscle ...
SHOU, Jian, CHEN, Pei-Jie, XIAO, Wei-Hua
openaire   +3 more sources

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia [PDF]

Nature, 2017
Reprogrammed cellular metabolism is a common characteristic observed in various cancers. However, whether metabolic changes directly regulate cancer development and progression remains poorly understood. Here we show that BCAT1, a cytosolic aminotransferase for branched-chain amino acids (BCAAs), is aberrantly activated and functionally required for ...
Hattori, Ayuna, Tsunoda, Makoto, Konuma, Takaaki, Kobayashi, Masayuki, Nagy, Tamas, Glushka, John, Tayyari, Fariba, McSkimming, Daniel, Kannan, Natarajan, Tojo, Arinobu, Edison, Arthur S., Ito, Takahiro   +11 more
openaire   +2 more sources

Supplementation with Branched-Chain Amino Acids Induces Unexpected Deleterious Effects on Astrocyte Survival and Intracellular Metabolism with or without Hyperammonemia: A Preliminary In Vitro Study

International Journal of Hepatology, 2021
Introduction. Ammonia is a key component in the pathogenesis of hepatic encephalopathy. Branched-chain amino acids (BCAA) have been reported to improve the symptoms of HE induced by hyperammonemia; however, we recently reported that ammonia increases ...
Ting Wang, Kazuyuki Suzuki, Toshimi Chiba, Keisuke Kakisaka, Yasuhiro Takikawa   +4 more
doaj   +1 more source

Serum branched chain amino acids: an effective indicator of diabetic kidney disease

Frontiers in Endocrinology, 2023
IntroductionIn recent years, there has been a growing association between elevated circulating levels of branched-chain amino acids (BCAA) and diabetes mellitus.
Min Liu, Min Liu, Yanhui Yang, Yanhui Yang, Yajin Liu, Yajin Liu, Xiaoyue Peng, Xiaoyue Peng, Yi Hou, Yi Hou, Xuejiao Zhang, Xuejiao Zhang, Haipeng Sun, Haipeng Sun, Chunyan Shan, Chunyan Shan   +15 more
doaj   +1 more source

Risk of liver-related death or transplantation according to quartiles of average BCAA intake (measured in grams of BCAA per 1000 kcal of daily energy intake).

, 2023
Risk of liver-related death or transplantation according to quartiles of average BCAA intake (measured in grams of BCAA per 1000 kcal of daily energy intake).
Lei Yu (70258), Jennifer Dodge (15353996), Kiran Bambha (15353999), Scott W. Biggins (15354002), Shirley C. Paski (15353993), George N. Ioannou (8792069)   +5 more
core   +1 more source

Excessive BCAA regulates fat metabolism partially through the modification of m6A RNA methylation in weanling piglets

Nutrition & Metabolism, 2020
Background Fat percentage and distribution in pigs are associated with their productive efficiency and meat quality. Dietary branched-chain amino acids (BCAA) regulate fat metabolism in weanling piglets with unknown mechanism.
Jinghui Heng, Zhihui Wu, Min Tian, Jiaming Chen, Hanqing Song, Fang Chen, Wutai Guan, Shihai Zhang   +7 more
doaj   +1 more source

Risk of liver-related death or transplantation according to quartiles of average daily absolute BCAA intake without accounting for total energy intake (measured in grams of BCAA).

, 2023
Risk of liver-related death or transplantation according to quartiles of average daily absolute BCAA intake without accounting for total energy intake (measured in grams of BCAA).
Lei Yu (70258), Jennifer Dodge (15353996), Kiran Bambha (15353999), Scott W. Biggins (15354002), Shirley C. Paski (15353993), George N. Ioannou (8792069)   +5 more
core   +1 more source