Results 11 to 20 of about 18,005 (233)

Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism [PDF]

open access: yesCell Metabolism, 2014
SummaryCirculating branched-chain amino acid (BCAA) levels are elevated in obesity/diabetes and are a sensitive predictor for type 2 diabetes. Here we show in rats that insulin dose-dependently lowers plasma BCAA levels through induction of hepatic ...
Ludger Scheja   +39 more
core   +4 more sources

Plasma BCAA changes in Patients with NAFLD are Sex Dependent 1 [PDF]

open access: yesThe Journal of Clinical Endocrinology & Metabolism, 2020
International audienceContext: Plasma branched chain amino acid (BCAA) concentrations correlate positively with body mass index (BMI), measures of insulin resistance (IR), and severity of nonalcoholic fatty liver disease (NAFLD).
Haas, Joel T.   +15 more
core   +5 more sources

Elevated BCAA Suppresses the Development and Metastasis of Breast Cancer

open access: yesFrontiers in Oncology, 2022
Branched-chain amino acids (BCAAs) are the three essential amino acids including leucine, isoleucine, and valine. BCAA metabolism has been linked with the development of a variety of tumors.
Rui Chi   +12 more
doaj   +3 more sources

A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents [PDF]

open access: yesMolecular Medicine, 2021
Background Elevations of circulating branched-chain amino acids (BCAA) are observed in humans with obesity and metabolic comorbidities, such as insulin resistance.
Sofia Moran-Ramos   +14 more
doaj   +3 more sources

Dysfunctional BCAA degradation triggers neuronal damage through disrupted AMPK-mitochondrial axis due to enhanced PP2Ac interaction

open access: yesCommunications Biology
Metabolic and neurological disorders commonly display dysfunctional branched-chain amino acid (BCAA) metabolism, though it is poorly understood how this leads to neurological damage.
Shih-Cheng Wu   +9 more
doaj   +3 more sources

Elevated branched-chain amino acid promotes atherosclerosis progression by enhancing mitochondrial-to-nuclear H2O2-disulfide HMGB1 in macrophages

open access: yesRedox Biology, 2023
As the essential amino acids, branched-chain amino acid (BCAA) from diets is indispensable for health. BCAA supplementation is often recommended for patients with consumptive diseases or healthy people who exercise regularly.
Shuai Zhao   +16 more
doaj   +1 more source

Association of Genetically Predicted BCAA Levels with Muscle Fiber Size in Athletes Consuming Protein [PDF]

open access: yes, 2022
Branched-chain amino acid (BCAA) levels are associated with skeletal muscle cross-sectional area (CSA). Serum BCAA levels are enhanced by whey protein supplementation (WPS), and evidence in clinical populations suggests an association of single ...
Hall, Elliott C R   +15 more
core   +1 more source

Effects of different doses of branched-chain amino acid supplementation on recovery following acute eccentric exercise

open access: yesTurkish Journal of Kinesiology, 2023
This study investigated the effect of different amounts of Branched-Chain Amino Acids (BCAA) supplementation on recovery from eccentric exercise. Nine healthy male subjects undertook 4 trials in a randomized crossover design. Participants ingested either
Huseyin Topçu   +5 more
doaj   +1 more source

Exercise Promotes BCAA Catabolism: Effects of BCAA Supplementation on Skeletal Muscle during Exercise [PDF]

open access: yesThe Journal of Nutrition, 2004
Branched-chain amino acids (BCAAs) are essential amino acids that can be oxidized in skeletal muscle. It is known that BCAA oxidation is promoted by exercise. The mechanism responsible for this phenomenon is attributed to activation of the branched-chain alpha-keto acid dehydrogenase (BCKDH) complex, which catalyzes the second-step reaction of the BCAA
Yoshiharu, Shimomura   +4 more
openaire   +2 more sources

A synthetic consortium of 100 gut commensals modulates the composition and function in a colon model of the microbiome of elderly subjects

open access: yesGut Microbes, 2021
Administration of cultured gut isolates holds promise for modulating the altered composition and function of the microbiota in older subjects, and for promoting their health. From among 692 initial isolates, we selected 100 gut commensal strains (MCC100)
Marta Perez   +6 more
doaj   +1 more source

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