Results 11 to 20 of about 25,183 (154)

Decreased Expression of CD314 by NK Cells Correlates with Their Ability to Respond by Producing IFN-γ after BCG Moscow Vaccination and Is Associated with Distinct Early Immune Responses

Vaccines, 2023
The immune response to vaccines is complex and results in various outcomes. BCG vaccination induces innate and specific responses that can lead to protection against tuberculosis, and cross-protection against other infections.
Adeliane Castro da Costa, Lília Cristina de Souza Barbosa, André Kipnis, Ana Paula Junqueira-Kipnis   +3 more
doaj   +1 more source

Oral vaccination with lipid-formulated BCG induces a long-lived, multifunctional CD4(+) T cell memory immune response. [PDF]

PLoS ONE, 2012
Oral delivery of BCG in a lipid formulation (Liporale™-BCG) targets delivery of viable bacilli to the mesenteric lymph nodes and confers protection against an aerosol Mycobacterium tuberculosis challenge.
Lindsay R Ancelet, Frank E Aldwell, Fenella J Rich, Joanna R Kirman   +3 more
doaj   +1 more source

Imprinting of Gut-Homing Receptors on Mtb-Specific Th1* Cells Is Associated with Reduced Lung Homing after Gavage BCG Vaccination of Rhesus Macaques

mBio, 2023
Alternative delivery routes of the current Mycobacterium tuberculosis (Mtb) vaccine, intradermally (ID) delivered BCG, may provide better protection against tuberculosis, and be more easily administered. Here, we use rhesus macaques to compare the airway
Stella G. Hoft, Keith D. Kauffman, Shunsuke Sakai, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Daniel F. Hoft, Richard Herbert, Daniel L. Barber   +7 more
doaj   +1 more source

BCG vaccination potential for COVID-19: an analytical approach

Human Vaccines & Immunotherapeutics, 2021
In order to assess the possible protective potential of BCG vaccination as regards to COVID-19, we have analyzed BCG vaccination status and SARS CoV-2 morbidity and mortality in China and we have also examined other studies performed in other countries ...
Mina T. Kelleni
doaj   +1 more source

Reactivation of BCG vaccination scars after vaccination with mRNA-Covid-vaccines: two case reports

BMC Infectious Diseases, 2021
Background From May 2020 to January 2021, we enrolled 1233 health care workers (HCW) from Danish Hospitals in a randomized trial evaluating whether Bacille Calmette-Guérin (BCG) provides protection against COVID-19.
Libin Mohamed, Anne Marie Rosendahl Madsen, Frederik Schaltz-Buchholzer, Anne Ostenfeld, Mihai G. Netea, Christine Stabell Benn, Poul-Erik Kofoed   +6 more
doaj   +1 more source

Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study

Cell Reports Medicine, 2020
Summary: Bacille Calmette-Guérin (BCG) induces long-term boosting of innate immunity, termed trained immunity, and decreases susceptibility to respiratory tract infections.
Simone J.C.F.M. Moorlag, Rosanne C. van Deuren, Cornelis H. van Werkhoven, Martin Jaeger, Priya Debisarun, Esther Taks, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Thijs ten Doesschate, Maartje C. Cleophas, Sanne Smeekens, Marije Oosting, Frank L. van de Veerdonk, Leo A.B. Joosten, Jaap ten Oever, Jos W.M. van der Meer, Nigel Curtis, Peter Aaby, Christine Stabell-Benn, Evangelos J. Giamarellos-Bourboulis, Marc Bonten, Reinout van Crevel, Mihai G. Netea   +23 more
doaj   +1 more source

Exploring spatial variation in BCG vaccination among children 0–35 months in Ethiopia: spatial analysis of Ethiopian Demographic and Health Survey 2016

BMJ Open, 2021
Objective Tuberculosis is a major public health problem and is the second leading cause of death worldwide. BCG vaccination is a life-saving and important part of standard tuberculosis control measures, particularly in Ethiopia where tuberculosis is ...
Chilot Desta Agegnehu, Adugnaw Zeleke Alem   +1 more
doaj   +1 more source

The association of Coronavirus Disease-19 mortality and prior bacille Calmette-Guerin vaccination: a robust ecological analysis using unsupervised machine learning

Scientific Reports, 2021
Population-level data have suggested that bacille Calmette-Guerin (BCG) vaccination may lessen the severity of Coronavirus Disease-19 (COVID-19) prompting clinical trials in this area. Some reports have demonstrated conflicting results.
Nathan A. Brooks, Ankur Puri, Sanya Garg, Swapnika Nag, Jacomo Corbo, Anas El Turabi, Noshir Kaka, Rodney W. Zemmel, Paul K. Hegarty, Ashish M. Kamat   +9 more
doaj   +1 more source

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials.

PLoS ONE, 2007
ObjectivesTo investigate the safety and immunogenicity of boosting BCG with modified vaccinia Ankara expressing antigen 85A (MVA85A), shortly after BCG vaccination, and to compare this first with the immunogenicity of BCG vaccination alone and second ...
Ansar A Pathan, Clare R Sander, Helen A Fletcher, Ian Poulton, Nicola C Alder, Natalie E R Beveridge, Kathryn T Whelan, Adrian V S Hill, Helen McShane   +8 more
doaj   +1 more source

Safety of BCG vaccination and revaccination in healthcare workers

Human Vaccines & Immunotherapeutics, 2023
BCG vaccination and revaccination are increasingly being considered for the protection of adolescents and adults against tuberculosis and, more broadly, for the off-target protective immunological effects against other infectious and noninfectious ...
Paola Villanueva, Nigel W. Crawford, Mariana Garcia Croda, Simone Collopy, Bruno Araújo Jardim, Tyane de Almeida Pinto Jardim, Helen Marshall, Cristina Prat-Aymerich, Alice Sawka, Ketaki Sharma, Darren Troeman, Ushma Wadia, Adilia Warris, Nicholas Wood, Nicole L. Messina, Nigel Curtis, Laure F. Pittet   +16 more
doaj   +1 more source