Results 131 to 140 of about 59,389 (246)
IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia [PDF]
, 2020 Chunhua Song +30 more
openalex +1 more source
Advanced Science, Volume 13, Issue 7, 3 February 2026.Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang +14 more
wiley +1 more source
Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity [PDF]
, 2017 Hana Park +8 more
openalex +1 more source
Cell Biochemistry and Function, Volume 44, Issue 2, February 2026.ABSTRACT Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stress, can induce protein denaturation, leading to misfolded or aggregated proteins.
Paka Sravan Kumar +5 more
wiley +1 more source
Hypercapnia Effects on Lung Function
Comprehensive Physiology, Volume 16, Issue 1, February 2026.CO2 is a signaling molecule that disrupts alveolar fluid clearance and ion transport, impairs alveolar repair, and promotes mitochondrial and endoplasmic reticulum dysfunction. It suppresses innate immunity, host defense, and inflammation, while increasing airway contractility.
Seungseo Choi +2 more
wiley +1 more source
Ecology and Evolution, Volume 16, Issue 2, February 2026.This study developed and validated 14 polymorphic microsatellite markers to investigate the population genetics of Hyalomma rufipes, a tick species that transmits Crimean‐Congo Hemorrhagic Fever Virus (CCHFV) in East Africa. Ticks collected from livestock in northern Kenya were morphologically and genetically identified, followed by genome sequencing ...
Hamza Ahmad +14 more
wiley +1 more source
Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation
Food Science &Nutrition, Volume 14, Issue 2, February 2026.Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid +7 more
wiley +1 more source
Nature CommunicationsOverexpressed pro-survival B-cell lymphoma-2 (BCL-2) family proteins BCL-2 and BCL-XL can render tumor cells malignant. Leukemia drug venetoclax is currently the only approved selective BCL-2 inhibitor. However, its application has led to an emergence of
Fengwei Li +15 more
doaj +1 more source
Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials
Food Science &Nutrition, Volume 14, Issue 2, February 2026.Curcuminoids remain one of the most studied dietary polyphenols as a cancer prevention and treatment agent. Inflammation and tumor progression are related to the NF‐κB signaling pathway, which is also suppressed by curcuminoids. Curcuminoids prevent the activation of a variety of signaling pathways, including the MAPK, PI3K/Akt, and NF‐kB pathways ...
Ushna Momal +14 more
wiley +1 more source