Results 131 to 140 of about 45,247 (265)

Ceramide channels: destabilization by Bcl-xL and role in apoptosis

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2015
Ceramide is a bioactive sphingolipid involved in mitochondrial-mediated apoptosis. Our data suggest that ceramides directly regulate a key initiation step in apoptosis: mitochondrial outer membrane permeabilization (MOMP). MOMP allows release of intermembrane space proteins to the cytosol, inducing the execution of the cell.
Kai-Ti Chang, Levi J. Beverly, Gauri A. Patwardhan, Leah J. Siskind, Andriy Anishkin, Marco Colombini   +5 more
openaire   +3 more sources

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Circulating let‐7 Predicts Hepatic Fibrogenesis of 12‐Month Post‐Nucleos(t)ide Analog Treatment in Patients With Hepatitis B Virus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Chronic hepatitis B virus (HBV) infection is associated with potential complications of liver cirrhosis and hepatocellular carcinoma. To date, there are no effective and noninvasive clinical markers that can predict the risk of liver fibrosis early and accurately in chronic hepatitis B (CHB) patients treated with nucleos(t)ide analogs (NAs ...
Yi‐Shan Tsai, Po‐Cheng Liang, Yi‐Hung Lin, Tyng‐Yuan Jang, Yu‐Ju Wei, Po‐Han Chen, Jia‐Ning Hsu, Meng‐Hsuan Hsieh, Ming‐Yen Hsieh, Chih‐Wen Wang, Zu‐Yau Lin, Ming‐Lun Yeh, Chung‐Feng Huang, Jee‐Fu Huang, Ming‐Lung Yu, Wan‐Long Chuang, Chia‐Yen Dai   +16 more
wiley   +1 more source

Bax mitochondrial relocation is linked to its phosphorylation and its interaction with Bcl-xL

Microbial Cell, 2016
The heterologous expression of Bax, and other Bcl-2 family members, in the yeast Saccharomyces cerevisiae, has proved to be a valuable reporter system to investigate the molecular mechanisms underlying their interaction with mitochondria.
David Garenne, Thibaud T. Renault, Stéphen Manon   +2 more
doaj   +1 more source

Association between Virulence Factors and TRAF1/4-1BB/Bcl-xL [PDF]

, 2015
Objective. CagA+/vacAs1+/vacAm1+ Helicobacter pylori upregulates the expression of tumor necrosis factor receptor–associated factor 1 (TRAF1), tumor necrosis factor receptor superfamily member 9 (4-1BB), and B-cell lymphoma-extra large (Bcl-xL) in human ...
Canxia Xu, Fen Wang, Guangkui Bu, Jin Peng, Nanfang Qu, Shourong Shen, Xiang Wu, Xiayu Li, Yi Yuan, Zhiying Liu   +9 more
core   +2 more sources

MCL-1 and BCL-XL: blood brothers [PDF]

Blood, 2021
Miriam Erlacher, Verena Labi
openaire   +4 more sources

The Role of Tumor Budding in Early‐Stage Laryngeal Cancer Treatment Selection

The Laryngoscope, EarlyView.
The search for treatment choices in the treatment of early‐stage laryngeal cancer is still ongoing. In this group with high treatment rates, it is important to be able to predict the unsuccessful group in advance. Tumor budding shows promising results. The failure rate after radiotherapy is high in patients with tumor budding of 2 or more.
Mehmet Birinci, Oğuz Gül, Oğuzhan Okcu, Tuğba Yemiş, Bayram Şen, Metin Çeliker, Çiğdem Öztürk, Özlem Çelebi Erdivanlı   +7 more
wiley   +1 more source

Bcl‐xL interrupts oxidative activation of neutral sphingomyelinase

FEBS Letters, 2002
Recent studies demonstrate a role for intracellular oxidation in the regulation of neutral sphingomyelinase (N‐SMase). Glutathione (GSH) has been shown to regulate N‐SMase in vitro and in cells. However, it has not been established whether the effects of GSH in cells are due to direct action on N‐SMase.
Lina M. Obeid, Yusuf A. Hannun, Yasuo Okamoto   +2 more
openaire   +3 more sources

Self‐Assembly of Noncanonical Peptides: A New Frontier in Cancer Therapeutics and Beyond

Macromolecular Bioscience, EarlyView.
Representative examples of noncanonical peptide assemblies in anticancer therapeutics, biomaterials, regenerative medicine, molecular imaging, and catalysis are discussed, highlighting enzyme‐instructed self‐assembly as a valuable approach for constructing biomimetic and bioinspired materials that bridge the interface between biological systems and ...
Lin Bai, Meihui Yi, Bing Xu
wiley   +1 more source

Fabrication of Carbon Nanodots/Platinum Functionalized Nanocomposite Hydrogel Formulation for Near‐Infrared Responsive Delivery of Doxorubicin to Promote Necroptosis for Mitigating Lung Cancer Cells: In Vitro Photodynamic Therapy

Macromolecular Materials and Engineering, EarlyView.
Representation of fabrication of carbon nanodots/platinum functionalized nanocomposite hydrogel formulation for near‐infrared responsive delivery of doxorubicin for lung cancer treatment. Abstract Lung cancer remains one of the deadliest cancers, marked by uncontrolled cell growth in the lungs and often diagnosed at later stages.
Xiaoqin An, Junjun Bai, Yuan Li
wiley   +1 more source