Results 161 to 170 of about 45,247 (265)

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

Aging Cell, EarlyView.
Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik, Ádám Nyúl‐Tóth, Rafal Gulej, Roland Patai, Tamas Kiss, Jordan Delfavero, Raghavendra Y. Nagaraja, Priya Balasubramanian, Santny Shanmugarama, Anna Ungvari, Siva Sai Chandragiri, Kiana Vali Kordestan, Mark Nagykaldi, Peter Mukli, Andriy Yabluchanskiy, Sharon Negri, Stefano Tarantini, Shannon Conley, Tae Gyu Oh, Zoltan Ungvari, Anna Csiszar   +20 more
wiley   +1 more source

Bcl-xL protects adult septal cholinergic neurons from axotomized cell death [PDF]

, 1998
Ulrike Blömer, Tal Kafri, Lynne Randolph‐Moore, Inder M. Verma, Fred H. Gage   +4 more
openalex   +1 more source

Aerobic Exercise Restores Hippocampal Neurogenesis and Cognitive Function by Decreasing Microglia Inflammasome Formation Through Irisin/NLRP3 Pathway

Aging Cell, EarlyView.
Exercise improved PD pathology and memory by reducing microglial inflammation, apoptosis, and the formation of the NLRP3 inflammasome via irisin signaling. Irisin administration partially replicated the beneficial effects of exercise on PD pathology.
Renqing Zhao, Xin Tian, Haocheng Xu, Yuanxin Wang, Junjie Lin, Bin Wang   +5 more
wiley   +1 more source

TNF receptor-2-triggered apoptosis is associated with the down-regulation of Bcl-xL on activated T cells and can be prevented by CD28 costimulation. [PDF]

, 1997
R H Lin, Yu‐Wen Hwang, Baichun Yang, C. S. Lin   +3 more
openalex   +1 more source

Single‐Cell RNA‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury

Aging Cell, EarlyView.
Microglia engage with apoptotic cells via cell‐surface receptors, such as proto‐oncogene tyrosine‐protein kinase MER (MerTK) and Axl; these receptors interact with the bridging molecule growth arrest‐specific 6 (Gas6) on apoptotic cells. Young microglia demonstrate efficient efferocytosis of apoptotic cells, but this process is impaired in aged ...
Pan Liu, Qi Wang, Shuimiao Wang, Ying Liu, Qiqi Chen, Wanyun Qin, Xinna Liu, Xinqi Ye, Yexuan Jiao, Huiping Yuan, Zhengbo Shao   +10 more
wiley   +1 more source

Age‐Related Oxidative Stress and Mitochondrial Dysfunction in Lymph Node Stromal Cells Limit the Peripheral T Cell Homeostatic Maintenance and Function

Aging Cell, EarlyView.
Aging of the lymph node stromal cells limits their ability to support the survival and maintenance of peripheral naive T cells. The lymph node stromal cells are critical for providing the survival and trophic signals to peripheral naïve T cells, and after the early‐life thymic involution, these secondary lymphoid organ stromal microniches are decisive ...
Sandip Ashok Sonar, Ruchika Bhat, Heather L. Thompson, Christopher P. Coplen, Jennifer L. Uhrlaub, Mladen Jergovic, Janko Ž. Nikolich   +6 more
wiley   +1 more source

Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma

, 1994
Gabriel
openalex   +2 more sources

Quercetin Reduces Vascular Senescence and Inflammation in Symptomatic Male but Not Female Coronary Artery Disease Patients

Aging Cell, EarlyView.
In male patients undergoing CABG surgery, pretreatment with quercetin suppressed inflammaging and its associated inflammation, leading to improved endothelium‐dependent relaxation (measured ex vivo) and reducing new onset of post‐operative atrial fibrillation.
Pauline Mury, Olina Dagher, Annik Fortier, Ariel Diaz, Yoan Lamarche, Pierre‐Emmanuel Noly, Marina Ibrahim, Pierre Pagé, Philippe Demers, Denis Bouchard, Pierre‐Luc Bernier, Nancy Poirier, Emmanuel Moss, Nicolas Durrleman, Hughes Jeanmart, Michel Pellerin, Guillaume Lettre, Nathalie Thorin‐Trescases, Michel Carrier, Eric Thorin   +19 more
wiley   +1 more source

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

, 1995
Elizabeth Yang, Jiping Zha, Jennifer Jockel, Lawrence Boise, Craig B. Thompson, Stanley J. Korsmeyer   +5 more
openalex   +1 more source

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo [PDF]

, 2000
Russell G. Jones, Michael Parsons, Madeleine Bonnard, Vera Chan, Wen‐Chen Yeh, James R. Woodgett, Pamela S. Ohashi   +6 more
openalex   +1 more source