Results 161 to 170 of about 95,261 (258)

Purification, Structural Characterization, and Anticancer Activity of the Polysaccharide From Sea Red Rice Bran

Food Frontiers, Volume 7, Issue 2, March 2026.
Sea red rice bran polysaccharides were separated and purified by DEAE‐52 column chromatography, yielding three components: SRBP‐I, II, and III. Moreover, all three are pentosan‐type polysaccharides predominantly composed of mannose. Among them, SRBP‐I demonstrated the most potent inhibitory effect on HeLa cells. Further investigation indicated that the
Jianping Chen, Cen Chen, Xiaoyin Wang, Xiaofei Liu, Jingjing Wang, Bin Zhong, Haocheng Liu, Jien Tan, Shengquan Ye   +8 more
wiley   +1 more source

Vitamin D Attenuates Inflammation and Mitochondrial Dysfunction in Experimental Models Relevant to Connective Tissue Disease–Associated Pulmonary Arterial Hypertension

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Mechanism study of VD mediated inflammatory and mitochondrial homeostasis in early PAH progression. ABSTRACT Vitamin D (VD) deficiency is prevalent in chronic inflammatory disorders and has been implicated in cardiopulmonary diseases. This study investigated whether VD, as a nutritional factor, modulates inflammatory and mitochondrial homeostasis in ...
Yansheng Jin, Chaoqi Lu, Yi Ling, Juan Chen, Xiaozhong Li   +4 more
wiley   +1 more source

Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-XL by engaging a single-residue discrepancy

Nature Communications
Overexpressed pro-survival B-cell lymphoma-2 (BCL-2) family proteins BCL-2 and BCL-XL can render tumor cells malignant. Leukemia drug venetoclax is currently the only approved selective BCL-2 inhibitor. However, its application has led to an emergence of
Fengwei Li, Junjie Liu, Chao Liu, Ziyan Liu, Xiangda Peng, Yinyue Huang, Xiaoyu Chen, Xiangnan Sun, Sen Wang, Wei Chen, Dan Xiong, Xiaotong Diao, Sheng Wang, Jingjing Zhuang, Chuanliu Wu, Dalei Wu   +15 more
doaj   +1 more source

Unraveling the role of TP53 mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito, Paula Sabbo Bernardo, Jean‐Edouard Martin, Caroline Marty, Isabelle Plo, Iléana Antony‐Debré, Bárbara da Costa Reis Monte‐Mór   +6 more
wiley   +1 more source

Preliminary Safety and Efficacy of Navitoclax Plus Ruxolitinib in Janus Kinase Inhibitor‐Naïve Patients With Myelofibrosis From the Multicenter, Open‐Label, Phase 2 Study (REFINE)

Hematological Oncology, Volume 44, Issue 2, March 2026.
ABSTRACT Myelofibrosis is characterized by perturbation of the JAK/STAT pathway and upregulation of anti‐apoptotic factors leading to myeloproliferation, bone marrow fibrosis (BMF), extramedullary hematopoiesis, splenomegaly, and cytopenias.
Francesco Passamonti, James M. Foran, Anand Tandra, Valerio De Stefano, Maria Laura Fox, Ahmad Mattour, Mary Frances McMullin, Andrew C. Perkins, Gabriela Rodriguez‐Macías, Hassan A. Sibai, Akshanth R. Polepally, Yan Sun, Avijeet S. Chopra, Jason G. Harb, Qin Qin, Jalaja Potluri, Jonathan How   +16 more
wiley   +1 more source

Crystal Structure of Rat Bcl-xL [PDF]

Journal of Biological Chemistry, 1997
Masaharu Aritomi, Naoki Kunishima, Naohiro Inohara, Yoshitomo Ishibashi, Shigeo Ohta, Kosuke Morikawa   +5 more
openaire   +1 more source

Quercetin and Its Nano‐Based Formulations Against Skin Cancer: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Skin cancer is one of the most prevalent malignancies worldwide, characterized by the abnormal growth of skin cells and significant clinical challenges. Conventional treatments—including surgery, chemotherapy, and radiotherapy—often suffer from limitations such as adverse side effects, tumor resistance, and inadequate efficacy.
Mahtab Khanyabzadeh, Alireza Emamifar, Nikoo Emtiazi, Amir Nazari, Masoumeh Shekarriz, Amin Karami, Fateme Hashem Beik Mahallati, Rahineh Nomani Lafmejani, Atieh Dariush, Seyed Mohammad Mahdi Rohani, Elaheh Mohseni Vadeghani, Negin Khoshnood, Hamid Reza Ojaghi, Fatemeh Rezaei‐Tazangi, Reza Arefnezhad   +14 more
wiley   +1 more source

Microbiome‐urothelium crosstalk in bladder cancer: From dysbiosis to clinical translation

iMetaOmics, Volume 3, Issue 1, March 2026.
This review elucidates the critical crosstalk between the urobiome and bladder cancer (BCa), mapping the landscape from ecological dysbiosis to clinical translation. We synthesize emerging evidence on microbial signatures that distinguish BCa patients, exploring key carcinogenic mechanisms including chronic inflammation, genotoxicity, and the gut ...
Haoxiang Xu, Zhibiao Li, Lin Yang, Jun Zheng, Weijia Li, Rulin Liao, Wenxue Huang, Boyuan Sun, Zhuohang Li, Cunzhen Ma, Xunguo Yang, Zongwei Wang, Jie Zhao, Bisheng Cheng, Peng Wu   +14 more
wiley   +1 more source

Cell Toxicity and Autophagy in A549 Cells Treated With Surface‐Functionalized Graphene Derivatives

Journal of Applied Toxicology, Volume 46, Issue 3, Page 821-832, March 2026.
ABSTRACT Graphene oxide and its derivatives have unique physical and chemical properties with applications in many different fields. However, their biological effects and mechanisms of intracellular toxicity have not been completely clarified. In this study, we investigated the cytotoxic and autophagic activities of graphene oxide and its derivatives ...
Tae Yun Park, Soo Young Kim, Chang Seok Park, Won Young Kim, Jae‐Woo Jung, Jae‐Yeol Kim, Jong Wook Shin   +6 more
wiley   +1 more source

Macromolecule‐Loaded Hybrid Extracellular Vesicles via Ionic Lipid–Based Post‐Loading for Intracellular Delivery: Functional Evaluation for Neurodegenerative Therapy

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
ABSTRACT Extracellular vesicles (EVs) are natural carriers that show promise as drug delivery systems (DDS). We developed a non‐invasive post‐loading method to encapsulate macromolecules in EVs using our proprietary ionic lipid base (ILB), which enables electrostatically driver hybridisation without disrupting EV structure.
Lin Cui, Fumiyasu Ono, Tomoko Ichinose, Masahiro Goto, Kohei Ishihama   +4 more
wiley   +1 more source