Results 171 to 180 of about 45,247 (265)

When, which and how to switch: Navigating JAK inhibitors in myelofibrosis

British Journal of Haematology, EarlyView.
Navigating choice of JAK inhibitor (JAKi) therapy for patients with myelofibrosis who are JAKi‐naïve and for those who have previously been treated with a JAKi.
Jennifer O'Sullivan, Imran Omerdeen, Bethan Psaila   +2 more
wiley   +1 more source

Identification of a novel regulatory domain in Bcl-xL and Bcl-2

, 1997
Brian S. Chang, Andy J. Minn, Steven W. Muchmore, Stephen W. Fesik, Craig B. Thompson   +4 more
openalex   +1 more source

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies [PDF]

, 2000
Andrew M. Petros, David G. Nettesheim, Yi Wang, Edward T. Olejniczak, ROBERT P. MEADOWS, JAMEY MACK, Kerry M. Swift, Edmund D. Matayoshi, HAICHAO ZHANG, CRAIG B. THOMPSON, Stephen W. Fesik   +10 more
openalex   +1 more source

Dual Targeting of Aurora‐A and Bcl‐xL Synergistically Reshapes the Immune Microenvironment and Induces Apoptosis in Breast Cancer

Cancer Science, EarlyView.
The combination of the Aurora‐A kinase inhibitor MLN8237 and the BH3 mimetic ABT263 enhanced anti‐tumor immunity by boosting CD8+ T cells and natural killer cells, while reducing immunosuppressive cells in the tumor microenvironment. It induced apoptosis via extrinsic and intrinsic pathways with minimal toxicity, offering a promising therapeutic ...
Mingxue Liu, Jing Guo, Weiyong Liu, Zhenye Yang, Fazhi Yu   +4 more
wiley   +1 more source

Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with Bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability

, 1999
Tetsuo Imazu, Shigeomi Shimizu, Shinji Tagami, Mieko Matsushima, Yusuke Nakamura, Tsuneharu Miki, Äkïhïko Okuyama, Yoshihide Tsujimoto   +7 more
openalex   +1 more source

Novel TEAD1 Inhibitor VT103 Enhances Dabrafenib Efficacy in BRAF V600E Mutated Lung Adenocarcinoma via Survivin Downregulation

Cancer Science, EarlyView.
We established a novel patient‐derived BRAF V600E‐mutated lung adenocarcinoma cell line and demonstrated that combining a novel TEAD1 inhibitor (VT103) with dabrafenib enhances therapeutic efficacy through survivin downregulation. Our tissue microarray analysis revealed a strong correlation between YAP1, TEAD1, and survivin expression in lung ...
Kazutaka Hosoya, Hiroaki Ozasa, Hironori Yoshida, Hitomi Ajimizu, Takahiro Tsuji, Masatoshi Yamazoe, Tatsuya Ogimoto, Kentaro Hashimoto, Tomoko Funazo (Yamamoto), Keiichiro Suminaga, Yusuke Shima, Hiroshi Yoshida, Takashi Nomizo, Hiroaki Ito, Kazuhiro Terada, Shigeto Nishikawa, Toshi Menju, Akihiko Yoshizawa, Hiroshi Date, Toyohiro Hirai   +19 more
wiley   +1 more source

CXCL13 and CCL21 Induce Tertiary Lymphoid Structures and Enhance the Efficacy of Immunotherapy for Melanoma

Cancer Science, EarlyView.
Plasma CCL21 levels were significantly increased in tertiary lymphoid structures (TLS)‐positive melanoma cases both before and after immune checkpoint inhibitors (ICI) treatment, while CXCL13 levels were significantly elevated after ICI treatment. We successfully induced TLS by co‐administering CXCL13 and CCL21 in a mouse melanoma model, clarifying ...
Maki Yoshimitsu, Motoki Nakamura, Shinji Kano, Tetsuya Magara, Hiroshi Kato, Aiko Sakai, Masaya Sugiyama, Masashi Mizokami, Akimichi Morita   +8 more
wiley   +1 more source

Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection

, 1998
F Petschner, Christine Zimmermann, Andreas Strasser, Didier Grillot, Gabriel Núñez, Hanspeter Pircher   +5 more
openalex   +1 more source

Non-ionic detergent affects the conformation of a functionally active mutant of Bcl-XL [PDF]

, 2000
Yee‐Joo Tan, Anthony E. Ting
openalex   +1 more source

Inhibition of Alkbh5 Attenuates Lipopolysaccharide‐Induced Lung Injury by Promoting Ccl1 m6A and Treg Recruitment

Cell Proliferation, EarlyView.
In septic lung injury mice, Alkbh5 is highly expressed, promoting the demethylation of m6A on Ccl1 mRNA, thereby reducing the stability of Ccl1 mRNA and decreasing Ccl1 expression. This, in turn, leads to reduced recruitment of Tregs, further exacerbating the symptoms of septic lung injury.
Hongdou Ding, Xinnan Xu, Yaoyao Zhu, Xinyu Ling, Li Xu   +4 more
wiley   +1 more source