Results 11 to 20 of about 95,261 (258)
MDM2-BCL-XL PROTACs enable degradation of BCL-XL and stabilization of p53
Acta Materia Medica, 2022 Inhibition or degradation of the anti-apoptotic protein BCL-XL is a viable strategy for cancer treatment. Despite the recent development of PROTACs for degradation of BCL-XL, the choice of E3 ligase has been restricted to VHL and CRBN.
Mengyang Chang +4 more
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ΔN-Bcl-xL, a therapeutic target for neuroprotection
Neural Regeneration Research, 2017 The B-cell lymphoma-extra large (Bcl-xL) is a mitochondrial anti-apoptotic protein that plays a role in neuroprotection. However, during excitotoxic stimulation, Bcl-xL undergoes caspase-dependent cleavage and produces a fragmented form, ΔN-Bcl-xL ...
Han-A Park, Elizabeth A Jonas
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Nutritional Regulators of Bcl-xL in the Brain [PDF]
Molecules, 2018 B-cell lymphoma-extra large (Bcl-xL) is an anti-apoptotic Bcl-2 protein found in the mitochondrial membrane. Bcl-xL is reported to support normal brain development and protects neurons against toxic stimulation during pathological process via its roles ...
Han-A Park +4 more
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Advances in Bcl-xL Research 2.0
International Journal of Molecular Sciences, 2023 Apoptosis is a form of programmed cell death that is highly conserved in metazoan organisms, where it ensures the proper development and homeostasis of tissues [...]
Joann Kervadec, Muriel Priault
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Anti‐apoptotic protein BCL‐XL as a therapeutic vulnerability in gastric cancer
Animal Models and Experimental Medicine, 2023 Background New therapeutic targets are needed to improve the outcomes for gastric cancer (GC) patients with advanced disease. Evasion of programmed cell death (apoptosis) is a hallmark of cancer cells and direct induction of apoptosis by targeting the ...
Yumin Wei +11 more
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Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. [PDF]
PLoS ONE, 2010 Autophagy is described to be involved in homeostasis, development and disease, both as a survival and a death process. Its involvement in cell death proceeds from interrelationships with the apoptotic pathway.
Muriel Priault +5 more
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Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma
iScience, 2023 Summary: Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive lymphoid malignancy with a poor prognosis and lacks standard treatment. Targeted therapies are urgently needed.
Chuanxu Liu +15 more
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Bcl-xL Inhibitor ABT-737 Reveals a Dual Role for Bcl-xL in Synaptic Transmission [PDF]
Journal of Neurophysiology, 2008 A role for BCL-xL in regulating neuronal activity is suggested by its dramatic effects on synaptic function and mitochondrial channel activity. When recombinant BCL-xL is injected into the giant presynaptic terminal of squid stellate ganglion or applied directly to mitochondrial outer membranes within the living terminal, it potentiates synaptic ...
John A, Hickman +3 more
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Bcl-xL: A Focus on Melanoma Pathobiology
International Journal of Molecular Sciences, 2021 Apoptosis is the main mechanism by which multicellular organisms eliminate damaged or unwanted cells. To regulate this process, a balance between pro-survival and pro-apoptotic proteins is necessary in order to avoid impaired apoptosis, which is the cause of several pathologies, including cancer.
Anna Maria Lucianò +3 more
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DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas [PDF]
Journal of Hematology & Oncology, 2020 Abstract Background Patients with advanced T cell lymphomas (TCLs) have limited therapeutic options and poor outcomes in part because their TCLs evade apoptosis through upregulation of anti-apoptotic Bcl-2 proteins. Subsets of TCL cell lines, patient-derived xenografts (PDXs), and primary patient samples depend on Bcl-xL for survival.
Yonghan He +15 more
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