Results 11 to 20 of about 59,389 (246)
Bcl-xL inhibition potentiates interferon-induced apoptosis in MPN stem cells. [PDF]
Blood AdvBywater MJ +9 more
europepmc +3 more sources
Nutritional Regulators of Bcl-xL in the Brain [PDF]
Molecules, 2018 B-cell lymphoma-extra large (Bcl-xL) is an anti-apoptotic Bcl-2 protein found in the mitochondrial membrane. Bcl-xL is reported to support normal brain development and protects neurons against toxic stimulation during pathological process via its roles ...
Han-A Park +4 more
doaj +3 more sources
Oxidative stress battles neuronal Bcl-xL in a fight to the death
Neural Regeneration Research, 2021 Bcl-xL is a pro-survival protein of the Bcl2 family found in the mitochondrial membrane. Bcl-xL supports growth, development, and maturation of neurons, and it also prevents neuronal death during neurotoxic stimulation.
Han-A Park +2 more
doaj +1 more source
Biology, 2021 B-cell lymphoma-extra large (Bcl-xL) is a mitochondrial protein known to inhibit mitochondria-dependent intrinsic apoptotic pathways. An increasing number of studies have demonstrated that Bcl-xL is critical in regulating neuronal energy metabolism and ...
Joseph Jansen +6 more
doaj +1 more source
Bcl-XL inhibits membrane permeabilization by competing with Bax. [PDF]
PLoS Biology, 2008 Although Bcl-XL and Bax are structurally similar, activated Bax forms large oligomers that permeabilize the outer mitochondrial membrane, thereby committing cells to apoptosis, whereas Bcl-XL inhibits this process. Two different models of Bcl-XL function
Lieven P Billen +4 more
doaj +1 more source
Advances in Bcl-xL Research 2.0
International Journal of Molecular Sciences, 2023 Apoptosis is a form of programmed cell death that is highly conserved in metazoan organisms, where it ensures the proper development and homeostasis of tissues [...]
Joann Kervadec, Muriel Priault
openaire +2 more sources
Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice
Nature Communications, 2023 The anti-apoptotic function of Bcl-xL in the heart during ischemia/reperfusion is diminished by K-Ras-Mst1-mediated phosphorylation of Ser14, which allows dissociation of Bcl-xL from Bax and promotes cardiomyocyte death.
Michinari Nakamura +10 more
doaj +1 more source
BCL-XL as a tumour prognostic factor? [PDF]
Współczesna Onkologia, 2010 Bożenna Kaczmarek-Borowska +3 more
openalex +2 more sources
Anti‐apoptotic protein BCL‐XL as a therapeutic vulnerability in gastric cancer
Animal Models and Experimental Medicine, 2023 Background New therapeutic targets are needed to improve the outcomes for gastric cancer (GC) patients with advanced disease. Evasion of programmed cell death (apoptosis) is a hallmark of cancer cells and direct induction of apoptosis by targeting the ...
Yumin Wei +11 more
doaj +1 more source
Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. [PDF]
PLoS ONE, 2010 Autophagy is described to be involved in homeostasis, development and disease, both as a survival and a death process. Its involvement in cell death proceeds from interrelationships with the apoptotic pathway.
Muriel Priault +5 more
doaj +1 more source