Results 11 to 20 of about 45,247 (265)
Biology, 2021 B-cell lymphoma-extra large (Bcl-xL) is a mitochondrial protein known to inhibit mitochondria-dependent intrinsic apoptotic pathways. An increasing number of studies have demonstrated that Bcl-xL is critical in regulating neuronal energy metabolism and ...
Joseph Jansen +6 more
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Involvement of Bcl-xL in Neuronal Function and Development [PDF]
International Journal of Molecular Sciences, 2021 The B-cell lymphoma (Bcl-2) family of proteins are mainly known for their role in the regulation of apoptosis by preventing pore formation at the mitochondrial outer membrane and subsequent caspase activation. However, Bcl-2 proteins also have non-canonical functions, independent of apoptosis. Indeed, the cell death machinery, including Bcl-2 homologs,
Julie Bas, Trang Nguyen, Germain Gillet
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Bcl-xL: A Focus on Melanoma Pathobiology
International Journal of Molecular Sciences, 2021 Apoptosis is the main mechanism by which multicellular organisms eliminate damaged or unwanted cells. To regulate this process, a balance between pro-survival and pro-apoptotic proteins is necessary in order to avoid impaired apoptosis, which is the cause of several pathologies, including cancer.
Anna Maria Lucianò +3 more
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Bcl-xL in neuroprotection and plasticity [PDF]
Frontiers in Physiology, 2014 Accepted features of neurodegenerative disease include mitochondrial and protein folding dysfunction and activation of pro-death factors. Neurons that experience high metabolic demand or those found in organisms with genetic mutations in proteins that control cell stress may be more susceptible to aging and neurodegenerative disease. In neurons, events
Jonas, EA, Porter, GA, Alavian, KN
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Roles and Regulation of BCL-xL in Hematological Malignancies [PDF]
International Journal of Molecular Sciences, 2022 Members of the Bcl-2 family are proteins that play an essential role in the regulation of apoptosis, a crucial process in development and normal physiology in multicellular organisms. The essential mechanism of this family of proteins is given by the role of pro-survival proteins, which inhibit apoptosis by their direct binding with their counterpart ...
Mario Morales-Martínez, Mario I. Vega
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DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas [PDF]
Journal of Hematology & Oncology, 2020 Abstract Background Patients with advanced T cell lymphomas (TCLs) have limited therapeutic options and poor outcomes in part because their TCLs evade apoptosis through upregulation of anti-apoptotic Bcl-2 proteins. Subsets of TCL cell lines, patient-derived xenografts (PDXs), and primary patient samples depend on Bcl-xL for survival.
Yonghan He +15 more
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The Role of Bcl-xL Protein in Viral Infections [PDF]
International Journal of Molecular Sciences, 2021 Bcl-xL represents a family of proteins responsible for the regulation of the intrinsic apoptosis pathway. Due to its anti-apoptotic activity, Bcl-xL co-determines the viability of various virally infected cells. Their survival may determine the effectiveness of viral replication and spread, dynamics of systemic infection, and viral pathogenesis.
Zbigniew Wyżewski +3 more
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Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice
Nature Communications, 2023 The anti-apoptotic function of Bcl-xL in the heart during ischemia/reperfusion is diminished by K-Ras-Mst1-mediated phosphorylation of Ser14, which allows dissociation of Bcl-xL from Bax and promotes cardiomyocyte death.
Michinari Nakamura +10 more
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Advances in Bcl-xL Research 2.0
International Journal of Molecular Sciences, 2023 Apoptosis is a form of programmed cell death that is highly conserved in metazoan organisms, where it ensures the proper development and homeostasis of tissues [...]
Joann Kervadec, Muriel Priault
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Conformational states of the cytoprotective protein Bcl-xL [PDF]
Biophysical Journal, 2020 ABSTRACTBcl-xL is a major inhibitor of apoptosis, a fundamental homeostatic process of programmed cell death that is highly conserved across evolution. Because it plays prominent roles in cancer, Bcl-xL is a major target for anti-cancer therapy and for studies aimed at understanding its structure and activity.
Ryzhov, P. +5 more
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