Bcl‑xL‑specific BH3 mimetic A‑1331852 suppresses proliferation of fluorouracil‑resistant colorectal cancer cells by inducing apoptosis. [PDF]
Kato A +15 more
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A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Minimizes Ex Vivo Reservoirs from Patients. [PDF]
Chang LC +5 more
europepmc +1 more source
The Innate Immune System and the TRAIL-Bcl-XL Axis Mediate a Sex Bias in Lung Cancer and Confer a Therapeutic Vulnerability in Females. [PDF]
May L +19 more
europepmc +1 more source
HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells. [PDF]
Alcon C +10 more
europepmc +1 more source
Statement of Retraction: Upregulation of miR-140-5p uncouples mitochondria by targeting Bcl-xL in vascular smooth muscle cells in angiotensin II-induced hypertension. [PDF]
europepmc +1 more source
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Bcl-xl Expression in Multiple Myeloma
Medical Oncology, 2005In the present study the immunohistochemical expression of Bcl-xl, a downstream target of the IL-6-controlled signal transducer and activator of transcription-3 (Stat3) was studied in 40 multiple myeloma (MM) cases before treatment and 11 MM patients at relapse.
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Collection of simulations and free energy calculations used in the publication Bcl-xL dynamics under the lens of protein structure networks. Valentina Sora, Dionisio Sanchez, Elena Papaleo*,J Phys Chem B, 2021, 125(17):4308-4320. doi: 10.1021/acs.jpcb.0c11562.
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Bcl-xL overexpression in human hepatocellular carcinoma
International Journal of Oncology, 2002It is known that proliferation and apoptosis are closely related phenomena in liver cancer cells. In this study, using surgical specimens from 42 patients with hepatocellular carcinoma (HCC), we investigated the expression and localization of Bcl-xL, an antiapoptosis-related protein of the Bcl-2 family.
Jota, Watanabe +5 more
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BCL-xL Regulates Synaptic Plasticity
Molecular Interventions, 2006Mitochondria are the predominant organelle within many presynaptic terminals. During times of high synaptic activity, they affect intracellular calcium homeostasis and provide the energy needed for synaptic vesicle recycling and for the continued operation of membrane ion pumps.
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BCL-XL directly retrotranslocates the monomeric BAK
Cellular Signalling, 2019BCL-XL, an anti-apoptotic BCL-2 family protein, potently inhibits BAK oligomerization and the formation of toxic mitochondrial pores in response to cellular stress. This report aims to explore which form of mitochondrial monomeric and oligomerized BAK can be retrotranslocated by BCL-XL.
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