Results 231 to 240 of about 95,261 (258)

Bcl‑xL‑specific BH3 mimetic A‑1331852 suppresses proliferation of fluorouracil‑resistant colorectal cancer cells by inducing apoptosis. [PDF]

open access: yesOncol Rep
Kato A   +15 more
europepmc   +1 more source

The Innate Immune System and the TRAIL-Bcl-XL Axis Mediate a Sex Bias in Lung Cancer and Confer a Therapeutic Vulnerability in Females. [PDF]

open access: yesCancer Res
May L   +19 more
europepmc   +1 more source

HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells. [PDF]

open access: yesCell Death Differ
Alcon C   +10 more
europepmc   +1 more source
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Bcl-xl Expression in Multiple Myeloma

Medical Oncology, 2005
In the present study the immunohistochemical expression of Bcl-xl, a downstream target of the IL-6-controlled signal transducer and activator of transcription-3 (Stat3) was studied in 40 multiple myeloma (MM) cases before treatment and 11 MM patients at relapse.
Peeters, SDPWM   +3 more
openaire   +3 more sources

BCL-xL MD and PSN

2021
Collection of simulations and free energy calculations used in the publication Bcl-xL dynamics under the lens of protein structure networks. Valentina Sora, Dionisio Sanchez, Elena Papaleo*,J Phys Chem B, 2021, 125(17):4308-4320. doi: 10.1021/acs.jpcb.0c11562.
Tiberti, Matteo   +3 more
openaire   +1 more source

Bcl-xL overexpression in human hepatocellular carcinoma

International Journal of Oncology, 2002
It is known that proliferation and apoptosis are closely related phenomena in liver cancer cells. In this study, using surgical specimens from 42 patients with hepatocellular carcinoma (HCC), we investigated the expression and localization of Bcl-xL, an antiapoptosis-related protein of the Bcl-2 family.
Jota, Watanabe   +5 more
openaire   +2 more sources

BCL-xL Regulates Synaptic Plasticity

Molecular Interventions, 2006
Mitochondria are the predominant organelle within many presynaptic terminals. During times of high synaptic activity, they affect intracellular calcium homeostasis and provide the energy needed for synaptic vesicle recycling and for the continued operation of membrane ion pumps.
openaire   +2 more sources

BCL-XL directly retrotranslocates the monomeric BAK

Cellular Signalling, 2019
BCL-XL, an anti-apoptotic BCL-2 family protein, potently inhibits BAK oligomerization and the formation of toxic mitochondrial pores in response to cellular stress. This report aims to explore which form of mitochondrial monomeric and oligomerized BAK can be retrotranslocated by BCL-XL.
Bin Wang   +7 more
openaire   +2 more sources

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