Results 261 to 265 of about 45,247 (265)

Bcl-xL overexpression in human hepatocellular carcinoma

International Journal of Oncology, 2002
It is known that proliferation and apoptosis are closely related phenomena in liver cancer cells. In this study, using surgical specimens from 42 patients with hepatocellular carcinoma (HCC), we investigated the expression and localization of Bcl-xL, an antiapoptosis-related protein of the Bcl-2 family.
Seiji Matsuda, Jota Watanabe, Nobuaki Kobayashi, Kazuo Honda, Katsumi Mominoki, Fumiki Kushihata   +5 more
openaire   +3 more sources

A new assay for the discovery of Bcl-XL inhibitors

Il Farmaco, 2005
The Bcl-2 family of antiapoptotic proteins is commonly over expressed in many types of human cancer and remains one of the few validated targets. Antiapoptotic family proteins such as Bcl-2 and Bcl-XL function, at least in part, by binding proapoptotic members such as Bax and Bak and thereby prevent release of the apoptotic cascade of events. "BH3-only"
Anna Resconi, Rolando Lorenzetti, Guido Cimoli, Cristina Pisoni, Lucia Carrano, Silvio Parodi, Daniele Losi   +6 more
openaire   +3 more sources

Bax-independent inhibition of apoptosis by Bcl-XL

Nature, 1996
The Bcl-2-related protein, Bcl-XL, has been shown to block apoptosis induced by a variety of stimuli and to be a stronger protector against apoptosis than Bcl-2 under certain circumstances. Using site-specific mutagenesis, we show here that the amino-acid residues critical for protection of cells by Bcl-XL against Sindbis virus-induced apoptosis are ...
J. Marie Hardwick, Lawrence H. Boise, Beth Levine, Emily H. Cheng, Craig B. Thompson   +4 more
openaire   +2 more sources

BCL-XL directly retrotranslocates the monomeric BAK

Cellular Signalling, 2019
BCL-XL, an anti-apoptotic BCL-2 family protein, potently inhibits BAK oligomerization and the formation of toxic mitochondrial pores in response to cellular stress. This report aims to explore which form of mitochondrial monomeric and oligomerized BAK can be retrotranslocated by BCL-XL.
Bin Wang, Zihao Mai, Mengyan Du, Lu Wang, Fangfang Yang, Yunyun Ma, Xiaoping Wang, Tongsheng Chen   +7 more
openaire   +3 more sources

Bcl-xL Deamidation a Trigger for Apoptosis

Science's STKE, 2007
Using a transgenic mouse as a model for T cell lymphoma, Zhao et al . provide evidence that defective deamidation of Bcl-xL contributes to the apoptosis resistance and oncogenesis of thymocytes in these animals. These mice ( CD45 −/− lck F505
openaire   +2 more sources