Results 21 to 30 of about 95,261 (258)

Conformation of BCL-XL upon Membrane Integration [PDF]

Journal of Molecular Biology, 2015
BCL-XL is an anti-apoptotic BCL-2 family protein found both in the cytosol and bound to intracellular membranes. Structural studies of BCL-XL have advanced by deleting its hydrophobic C-terminus and adding detergents to enhance solubility. However, since the C-terminus is essential for function and detergents strongly affect structure and activity, the
Yong Yao, Lynn M. Fujimoto, Nathan Hirshman, Andrey A. Bobkov, Antonella Antignani, Richard J. Youle, Francesca M. Marassi   +6 more
openaire   +2 more sources

Targeting BCL-XL in fibrolamellar hepatocellular carcinoma

JCI Insight, 2022
Fibrolamellar hepatocellular carcinoma (FLC) is a rare and often lethal liver cancer with no proven effective systemic therapy. Inhibition of the antiapoptotic protein BCL-XL was found to synergize with a variety of systemic therapies in vitro using cells dissociated from patient-derived xenografts (PDX) of FLC or cells dissociated directly from ...
Bassem Shebl, Denise Ng, Gadi Lalazar, Carly Rosemore, Tova M. Finkelstein, Rachael D. Migler, Guangrong Zheng, Peiyi Zhang, Caroline S. Jiang, Adam Qureshi, Roger Vaughan, Mark Yarchoan, Ype P. de Jong, Charles M. Rice, Philip Coffino, Michael V. Ortiz, Daohong Zhou, Sanford M. Simon   +17 more
openaire   +3 more sources

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Conformational states of the cytoprotective protein Bcl-xL [PDF]

Biophysical Journal, 2020
ABSTRACTBcl-xL is a major inhibitor of apoptosis, a fundamental homeostatic process of programmed cell death that is highly conserved across evolution. Because it plays prominent roles in cancer, Bcl-xL is a major target for anti-cancer therapy and for studies aimed at understanding its structure and activity.
Ryzhov, P., Tian, Y., Yao, Y., Bobkov, A. A., Im, W., Marassi, F. M.   +5 more
openaire   +2 more sources

Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells [PDF]

, 2013
Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP).
A Jemal, A Krueger, A Krueger, A Younes, AR Safa, BR Seo, C Liu, C Odoux, CH Mom, D Atallah, D Mahalingam, DB Longley, E Raymond, FA Greco, GJ Ullenhag, HJ Zeh 3rd, HR Alexander Jr., IA Mawji, IN Lavrik, J Yoo, JA Ubersax, JM Cummins, JW Yu, L Zhang, L Zhao, LR Hafström, LY Dimberg, M Irmler, M Upreti, M Vulfovich, MA Alcala Jr., MJ Lee, P Korkolopoulou, Raffaele A Calogero, S Hegewisch-Becker, S Varghese, Seog-Young Kim, SK Libutti, T Bartke, T Ruers, T Trarbach, TR Wilson, W Gao, X Song, X Song, X Song, Xinxin Song, Y Jin-Song, Y Lin, YJ Lee, YL Zhang, Yong J. Lee, Z El Fajoui   +52 more
core   +7 more sources

Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl‐xL in successful aging [PDF]

, 2016
Centenarians not only enjoy an extraordinary aging, but also show a compression of morbidity. Using functional transcriptomic analysis of peripheral blood mononuclear cells (PMBC) we identified 1721 mRNAs differentially expressed by centenarians when ...
Abdelaziz, Kheira M., Avellana, Juan Antonio, Barettino, Ana, Belenguer, Ángel, Borras, Consuelo, Errigo, Alessandra, Flames, Nuria, Fuente del Rey, Mónica de la, Gambini, Juan, García, Idoia, Inglés, Marta, Lloret Fernández, Carla, Matheu, Ander, Pes, Gianni, Rodriguez Mañas, Leocadio, Sanchís, Paula, Serna, Eva, Viña, José   +17 more
core   +5 more sources

Gain of 20q11.21 in human pluripotent stem cells impairs TGF-β-dependent neuroectodermal commitment [PDF]

, 2019
Gain of 20q11.21 is one of the most common recurrent genomic aberrations in human pluripotent stem cells. Although it is known that overexpression of the antiapoptotic gene Bcl-xL confers a survival advantage to the abnormal cells, their differentiation ...
De Deckersberg, E. Couvreu, De Kock, J., Dziedzicka, D., Franceschini, L., Geens, M., Keller, A., Markouli, C., Nguyen, H. T., Regin, M., Sermon, K., Spits, C., Tilleman, Laurentijn, Van Nieuwerburgh, Filip, Zambelli, F.   +13 more
core   +1 more source

PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors

Exploration of Targeted Anti-tumor Therapy, 2020
BCL-XL is an anti-apoptotic protein that plays an important role in tumorigenesis, metastasis, and intrinsic or therapy-induced cancer drug resistance.
Peiyi Zhang, Xuan Zhang, Xingui Liu, Sajid Khan, Daohong Zhou, Guangrong Zheng   +5 more
doaj   +1 more source

Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy [PDF]

, 2017
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anti-cancer targets. Using small cell lung cancer (SCLC) as a model, we demonstrated the presence of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-
Chen, Hui-Chen, Cheng, Emily H, Dong, Yiyu, Ganesan, Yogesh Tengarai, Han, Song, Hellmann, Matthew D, Hsieh, James J, Inoue-Yamauchi, Akane, Ishizawa, Kota, Jebiwott, Sylvia, Jeng, Paul S, Kim, Kwanghee, Kris, Mark G, Pietanza, Maria C   +13 more
core   +2 more sources

A Caspase-Resistant Form of Bcl-XL, but Not Wild Type Bcl-XL, Promotes Clonogenic Survival After Ionizing Radiation

Neoplasia: An International Journal for Oncology Research, 1999
Bcl-2 and Bcl-XL belong to a family of proteins overexpressed in a variety of human cancers which inhibit apoptosis in response to a number of stimuli including chemotherapeutic agents and ionizing radiation.
Alnawaz Rehemtulla, A. Christin Hamilton, Neelam Taneja, Jordan Fridman, Todd S.C. Juan, Jonathan Maybaum, Arul Chinnaiyan   +6 more
doaj   +1 more source