BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians. [PDF]
, 2020 B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-
Borrás, Consuelo +7 more
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Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro. [PDF]
PLoS ONE, 2013 Migration and invasion of malignant cells are prerequisites for cancer progression and metastasis. The Bcl-2 family of proteins consists of about 25 members and has been extensively studied in the context of apoptosis.
Bruno Christian Koehler +9 more
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BCL-XL overexpression promotes tumor progression-associated properties article [PDF]
, 2017 By using human melanoma and glioblastoma cell lines and their derivative BCL-XL overexpressing clones, we investigated the role of BCL-XL in aggressive features of these two tumor histotypes.
Alessandrini, Gabriele +9 more
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Haematologica, 2023 BCL-XL and BCL-2 are key anti-apoptotic proteins and validated cancer targets. 753B is a novel BCL-XL/BCL-2 proteolysis targeting chimera (PROTAC) that targets both BCL-XL and BCL-2 to the von Hippel-Lindau (VHL) E3 ligase, leading to BCLX L/BCL-2 ...
Yannan Jia +19 more
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BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer [PDF]
, 2022 The heterogeneous therapy response observed in colorectal cancer is in part due to cancer stem cells (CSCs) that resist chemotherapeutic insults. The anti-apoptotic protein BCL-XL plays a critical role in protecting CSCs from cell death, where its ...
Atencia Taboada, Lidia +6 more
core +1 more source
The Structural Biology of Bcl-xL [PDF]
International Journal of Molecular Sciences, 2019 Interactions between the pro-survival and pro-apoptotic members of the Bcl-2 family of proteins dictate whether a cell lives or dies. Much of our knowledge of the molecular details of these interactions has come from biochemical and structural studies on the pro-survival protein Bcl-xL. The first high-resolution structure of any Bcl-2 family member was
Erinna F. Lee, W. Douglas Fairlie
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High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia. [PDF]
, 2016 Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a predictive biomarker of disease progression in many malignancies, including imatinib-treated chronic myeloid leukemia (CML).
Butterworth, M. +7 more
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The Effects of Thymoquinone on Viability, and Anti-apoptotic Factors (BCL-XL, BCL-2, MCL-1) in Prostate Cancer (PC3) Cells: An In Vitro and Computer-Simulated Environment Study [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: Since active plant ingredients can induce apoptosis in many tumors, in this study we evaluate the apoptotic effects of thymoquinone (TQ) on PC3 cells.
Javad Saffari_Chaleshtori +3 more
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Regulation of Bcl-xl Channel Activity by Calcium [PDF]
Journal of Biological Chemistry, 1998 Recent studies have demonstrated that the anti-apoptotic proteins, Bcl-2 and Bcl-xl, with the carboxyl-terminal hydrophobic domain removed, form cation-selective channels in the lipid bilayer reconstitution system. However, the regulatory properties of these channels are unknown.
Jianjie Ma +4 more
openaire +3 more sources
Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma
iScience, 2023 Summary: Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive lymphoid malignancy with a poor prognosis and lacks standard treatment. Targeted therapies are urgently needed.
Chuanxu Liu +15 more
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