Results 61 to 70 of about 45,247 (265)

Anti-Apoptotic Protein Bcl-xL Expression in the Midbrain Raphe Region Is Sensitive to Stress and Glucocorticoids. [PDF]

PLoS ONE, 2015
Anti-apoptotic proteins are suggested to be important for the normal health of neurons and synapses as well as for resilience to stress. In order to determine whether stressful events may influence the expression of anti-apoptotic protein Bcl-xL in the ...
Galina T Shishkina, Tatyana S Kalinina, Veta V Bulygina, Dmitry A Lanshakov, Ekaterina V Babluk, Nikolay N Dygalo   +5 more
doaj   +1 more source

Bad expression influences time to androgen escape in prostate cancer [PDF]

, 2007
<b>OBJECTIVE</b>: To assess the role of selected downstream Bcl-2 family members (Bad, Bax, Bcl-2 and Bcl-xL) in the development of androgen-independent prostate cancer (AIPC), as androgen-deprivation therapy is the treatment of choice in ...
Bracarda S, Chi KN, Edwards J, Eisenmann KM, Gleave M, Huggins C, Ichinose M, Kelekar A, Lebedeva I, McDonnell TJ   +9 more
core   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology

Angewandte Chemie, EarlyView.
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker, Adrian Pui Ting Ho, Laura S. Itzhaki, Ljiljana Fruk   +3 more
wiley   +2 more sources

Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis [PDF]

, 2020
Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further.
Aasumets, Koit, Akimov, Yevhen, Aman, Yahyah, Arutyunyan, Albert F., Bjørås, Magnar, Bugai, Andrii, Bugge, Marit, Bulanova, Daria, Fang, Evandro F., Gerhold, Joachim M., Gildemann, Kiira, Heckman, Caroline A., Holien, Toril, Ianevski, Aleksandr, Ji, Ping, Johansen, Pål, Kainov, Denis E., Krpina, Klara, Kulesskiy, Evgeny, Lou, Guofeng, Lysvand, Hilde, Oksenych, Valentyn, Susova, Olga Yu., Waage, Anders, Wang, Wei, Zhuze, Alexei L., Zusinaite, Eva   +26 more
core   +4 more sources

Stimulation of Bax Mitochondrial Localization by Bcl-xL [PDF]

Biophysical Journal, 2013
Cytochrome c release, the commitment step of apoptosis, is regulated at the mitochondria through protein-protein interactions between the Bcl-2 family proteins. An imbalance of this interaction network due to the up-regulation of the proto-oncogenes Bcl-2 and/or Bcl-xL lead to a resistance to apoptosis and is associated with tumor formation.
Yogesh Tengarai Ganesan, Thibaud T. Renault, Stéphen Manon, Gisèle Velours, Bruno Antonsson, Oscar Teijido, Nadine Camougrand, Laurent M. Dejean, Florent Missire   +8 more
openaire   +2 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Rational Design and Real Time, In-Cell Detection of the Proapoptotic Activity of a Novel Compound Targeting Bcl-XL [PDF]

, 2004
Antiapoptotic Bcl-2-family proteins Bcl-2 and Bcl-XL have been recently validated as drug discovery targets for cancer. Here, by using a combination of molecular modeling, NMR-based structural analysis, fluorescence polarization assays, and cell-based ...
Becattini, Barbara, Chandler, Sharon, Kipps, Thomas J, Kitada, Shinichi, Leone, Marilisa, Monosov, Edward, Pellecchia, Maurizio, Reed, John C, Zhai, Dayong   +8 more
core   +1 more source

Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models [PDF]

, 2020
Background: The multikinase inhibitor regorafenib, approved as second-line treatment for hepatocellular carcinoma (HCC) after sorafenib failure, may induce mitochondrial damage.
Boix i Ferrero, Loreto, Bruix, Jordi, Colell Riera, Anna, Cucarull, Blanca, García de Frutos, Pablo, Hernáez Alsina, Tania, Marí García, Montserrat, Morales Muñoz, Albert, Reig, María, Subias, Miguel, Tutusaus, Anna, Tutusaus, Anna   +11 more
core   +1 more source

BCL-XL-regulated apoptosis in T cell development [PDF]

International Immunology, 1997
Thymocyte differentiation progresses through well-defined stages in which apoptosis is central to the selection of a functional TCR repertoire. In the present study, we explored the developmental effects of BCL-XL, a repressor of apoptosis. We found that endogenous BCL-XL is down-regulated by both positive and negative selection signals at the CD4+ CD8+
Debra T. Chao, Stanley J. Korsmeyer
openaire   +3 more sources