Results 61 to 70 of about 59,389 (246)
BMC Cancer, 2006 Background Bcl-2 and Bcl-XL are anti-apoptotic paralogues that inhibit apoptosis elicited by a wide variety of stimuli, and play critical roles in cancer development and resistance to treatment.
Leber Brian +4 more
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BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo. [PDF]
PLoS ONE, 2014 Bcl-2 and Bcl-xL are critical regulators of apoptosis that are overexpressed in a variety of human cancers and pharmacological inhibition of Bcl-2 and Bcl-xL represents a promising strategy for cancer treatment.
Longchuan Bai +6 more
doaj +1 more source
Supplementary Methods from Novel Small-Molecule Inhibitors of Bcl-XL to Treat Lung Cancer [PDF]
, 2023 Dongkyoo Park +9 more
openalex +1 more source
Bcl‐xL interrupts oxidative activation of neutral sphingomyelinase
FEBS Letters, 2002 Recent studies demonstrate a role for intracellular oxidation in the regulation of neutral sphingomyelinase (N‐SMase). Glutathione (GSH) has been shown to regulate N‐SMase in vitro and in cells. However, it has not been established whether the effects of GSH in cells are due to direct action on N‐SMase.
Okamoto, Yasuo +2 more
openaire +2 more sources
A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β
Advanced Science, EarlyView.This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo +12 more
wiley +1 more source
A Bcl-xL Timer Sets Platelet Life Span [PDF]
Cell, 2007 Platelets are cell fragments lacking nuclei that play a key role in blood clotting. Using an impressive genetic screen involving ENU-mutagenesis of whole mice, Mason et al. (2007) report in this issue their identification of mutations in the antiapoptotic protein Bcl-x(L) that cause accelerated death of platelets leading to platelet deficiency.
Qi, Bing, Hardwick, J. Marie
openaire +2 more sources
Advanced Science, EarlyView.A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin +6 more
wiley +1 more source
Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer
Advanced Science, EarlyView.This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo +6 more
wiley +1 more source
Discover Oncology, 2022 One of the many strategies that cancer cells evade death is through up-regulation of the BCL-2 anti-apoptotic proteins. Hence, these proteins have become attractive therapeutic targets.
Siti Fairus Abdul Rahman +4 more
doaj +1 more source