Results 61 to 70 of about 95,261 (258)

miRNA-based rapid differentiation of purified neurons from hPSCs advancestowards quick screening for neuronal disease phenotypes in vitro [PDF]

, 2020
Obtaining differentiated cells with high physiological functions by an efficient, but simple and rapid differentiation method is crucial for modeling neuronal diseases in vitro using human pluripotent stem cells (hPSCs).
Aoyama, Takeshi, Ishikawa, Mitsuru, Miyoshi, Hiroyuki, Morota, Saori, Nakamura, Mari, Okano, Hideyuki, Shibata, Shoichiro, Sone, Takefumi, Uchino, Hiroyuki, Watanabe, Hirotaka, Yoo, Andrew S   +10 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic–ischemic brain injury via inhibition of caspases and AIF

Neurobiology of Disease, 2006
Systemic delivery of recombinant Bcl-xL fusion protein containing the TAT protein transduction domain attenuated neonatal brain damage following hypoxic ischemia (H–I).
Wei Yin, Guodong Cao, Michael J. Johnnides, Armando P. Signore, Yumin Luo, Robert W. Hickey, Jun Chen   +6 more
doaj   +1 more source

Expression of antiapoptotic protein Bcl-xL in optogeneticaly stimulated hippocampal glutamatergic neurons [PDF]

, 2017
The anti-apoptotic protein Bcl-xl takes part in processes of neuroplasticity such as synaptogenesis and release of neurotransmitters. In this study dependence of Bcl-xL expression on neuron activity was analyzed by in vivo optogenetic activating of the ...
Дрозд, У. С.
core  

Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins [PDF]

, 2015
Viral homologs of the anti-apoptotic Bcl-2 proteins are highly diverged from their mammalian counterparts, yet they perform overlapping functions by binding and inhibiting BH3 (Bcl-2 homology 3)-motif-containing proteins.
Foight, Glenna W., Keating, Amy E.
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Bcl-xL is required to protect endothelial cells latently infected with KSHV from virus induced intrinsic apoptosis.

PLoS Pathogens, 2023
Kaposi's Sarcoma herpesvirus (KSHV) is the etiologic agent of Kaposi's Sarcoma (KS), a highly vascularized tumor common in AIDS patients and many countries in Africa.
Lyndsey N Moore, Daniel L Holmes, Anjali Sharma, Joselyn Landazuri Vinueza, Michael Lagunoff   +4 more
doaj   +1 more source

Spontaneous Immunity against Bcl-xL in Cancer Patients [PDF]

The Journal of Immunology, 2005
Abstract It is well-established that peptide epitopes derived from human tumor-associated Ags can be recognized by CTL in the context of the MHC molecule. However, the vast majority of Ags described are not vital for survival and growth of the tumor cells, and immunoselection of Ag-loss variants during immunotherapy has been demonstrated
Mads Hald, Andersen, Sine, Reker, Pia, Kvistborg, Jürgen C, Becker, Per, thor Straten   +4 more
openaire   +2 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Anti-Apoptotic Protein Bcl-xL Expression in the Midbrain Raphe Region Is Sensitive to Stress and Glucocorticoids. [PDF]

PLoS ONE, 2015
Anti-apoptotic proteins are suggested to be important for the normal health of neurons and synapses as well as for resilience to stress. In order to determine whether stressful events may influence the expression of anti-apoptotic protein Bcl-xL in the ...
Galina T Shishkina, Tatyana S Kalinina, Veta V Bulygina, Dmitry A Lanshakov, Ekaterina V Babluk, Nikolay N Dygalo   +5 more
doaj   +1 more source