Results 101 to 110 of about 197,182 (311)

RGS14 (414)-mediated prevention of an episodic memory loss: a study of molecular mechanism [PDF]

, 2015
A large proportion of human populations suffer memory impairments either caused by normal aging or afflicted by diverse neurological and neurodegenerative diseases. Memory enhancers and other drugs tested so far against memory loss have failed to produce
Navarro Lobato, Irene
core   +1 more source

Cognitive appraisal of environmental stimuli induces emotion-like states in fish [PDF]

, 2017
The occurrence of emotions in non-human animals has been the focus of debate over the years. Recently, an interest in expanding this debate to non-tetrapod vertebrates and to invertebrates has emerged. Within vertebrates, the study of emotion in teleosts
A Zayed, AI Faustino, D Nettle, DJ Anderson, ES Paul, G Leal, G Liebsch, GJ Quirk, J Ganz, J Ganz, J LeDoux, JA Russell, JA Russell, JE LeDoux, JE Ploski, JF Lopez-Olmeda, JM McNamara, KC Berridge, KC Berridge, KP Maruska, L Galhardo, LA O’Connell, LF Barrett, M Mendl, MA Vindas, MA Vindas, P Ekman, PC Trimmer, R Landgraf, RJ Dolan, S Millot, S Millot, SD Cardoso, SE Wendelaar Bonga, T Brosch, T Kawashima, TP Sheehan, TW Fawcett, WT Gibson, X Sun, Y Benjamini, Y Lin   +41 more
core   +5 more sources

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Myocardial Disorders in BDNF-Deficient Rats: Limited Recovery Post-Moderate Endurance Training

Diabetes, Metabolic Syndrome and Obesity
Norbert Grzelak,1 Dominik Kaczmarek,2 Krystian Marek Poziemba,2 Włodzimierz Mrówczyński1 1Department of Neurobiology, Poznań University of Physical Education, Poznań, Poland; 2Department of Physiology and Biochemistry, Pozna ...
Grzelak N, Kaczmarek D, Poziemba KM, Mrówczyński W   +3 more
doaj  

Haloperidol’s Effect on the Expressions of TGFB, NT-3, and BDNF genes in Cultured Rat Microglia

Basic and Clinical Neuroscience, 2020
Introduction: Microglia, small glial cells, i.e. mesodermal in origin and found in the brain and spinal cord, play a key role in the maintenance of neurons and immune defense. Haloperidol, an antipsychotic drug, is used to treat numerous neurological and
Elham Namjoo, Mohammad Shekari, Aliyar Pirouzi, Hossein Forouzandeh, Davod Khalafkhany, Abdolvahid Vahedi, Iraj Ahmadi   +6 more
doaj  

Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]

, 2011
Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell, C. J. Rogers, Chao, Clement, de Paz, Dechant, Faham, Gama, Huang, K. C. Garcia, Keiser, Khunrae, Kim, L. C. Hsieh-Wilson, Lowes, Mukai, Mulloy, Oohira, P. M. Clark, Pellegrini, Petitou, R. Abrol, Raman, Rapp, Rawat, Raza, Roux, S. E. Tully, Schlessinger, Shelton, Shipp, Spivak-Kroizman, Strom, Sugahara, Sweeney, Tully, Tully, Vaudry, W. A. Goddard, Zhang   +39 more
core   +2 more sources

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Abnormal Cerebellar Development and Foliation in BDNF−/− Mice Reveals a Role for Neurotrophins in CNS Patterning [PDF]

, 1997
Phillip M. Schwartz, Paul R. Borghesani, Ronald Levy, Scott L. Pomeroy, Rosalind A. Segal   +4 more
openalex   +1 more source

MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia

, 2022
Rosmara Infantino, Concetta Schiano, Livio Luongo, Salvatore Paino, Gelsomina Mansueto, Serena Boccella, Francesca Guida, Flavia Ricciardi, Monica Iannotta, Carmela Belardo, Ida Marabese, Gorizio Pieretti, Nicola Serra, Claudio Napoli, Sabatino Maione   +14 more
openalex   +1 more source

TBIO-06. BDNF-TRKB SIGNALING REGULATES NEURON-GLIOMA SYNAPTOGENESIS AND PROMOTES TUMOR PROGRESSION [PDF]

, 2020
Kathryn R. Taylor, Helena Zhang, Alexa Hui, Shawn Gillespie, Michelle Monje   +4 more
openalex   +1 more source