Results 101 to 110 of about 196,397 (352)

Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior

, 2021
Danbi Jo, Juhyun Song
openalex   +1 more source

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

Advanced Science, EarlyView.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu, Weiguang Wang, Jian Zhang, Lei Liu, Minpeng Huang, Lei Diao, Shuang Feng, Qiong Yang, Hao Qiu, Bing Pan, Renee A Reijo Pera, Ji Liu, Ninuo Xia, Fang Fang   +13 more
wiley   +1 more source

Sex-Specific Associations of Brain-Derived Neurotrophic Factor and Cardiorespiratory Fitness in the General Population

Biomolecules, 2019
The brain-derived neurotrophic factor (BDNF) was initially considered to be neuron-specific. Meanwhile, this neurotrophin is peripherally also secreted by skeletal muscle cells and increases due to exercise.
Marie-Lena Schmalhofer, Marcello R.P. Markus, Jan C. Gras, Juliane Kopp, Deborah Janowitz, Hans-Jörgen Grabe, Stefan Groß, Ralf Ewert, Sven Gläser, Diana Albrecht, Ina Eiffler, Henry Völzke, Nele Friedrich, Matthias Nauck, Antje Steveling, Stephanie Könemann, Kristin Wenzel, Stephan B. Felix, Marcus Dörr, Martin Bahls   +19 more
doaj   +1 more source

Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]

, 2008
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko, Kambe, Yuki, Taniura, Hideo, Yoneda, Yukio   +3 more
core  

TNEA Regulates Hippocampal Oscillation by Improving Inhibitory Synaptic Plasticity to Ameliorates Cognitive Impairment in Alzheimer's Disease

Advanced Science, EarlyView.
TNEA improves cognition in 5xFAD mice by modulating parvalbumin‐positive interneurons in hippocampal CA1. TNEA enhances gamma oscillations during rest and theta power during novel object recognition, restoring excitation/inhibition balance. These findings support TNEA as a minimally invasive therapy for Alzheimer's disease.
Zhongzhao Guo, Hong Ni, Yu Lu, Zhengyu Cui, Yixing Wang, Zilu Zhu, Xinyu Wei, Chenyi Xia, Ming Xu, Lixia Du, Yufang Yang, Shi Shu, Ke Wang, Zhifei Wang, Chunlei Shan, Deheng Wang   +15 more
wiley   +1 more source

An Investigation of the Role of Sex Difference in the Effect of Fluoxetine on Behavioral and Biochemical Changes in Male and Female Rats Exposed to Stress [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Unpredictable stressors cause changes in behavioral parameters such as motor and exploratory behaviors, feeding, and sexual and anxiety behaviors. Stress leads to the release of corticosteroids and, as a result, causes dysfunction
Moslem Mohammadi, Zahra Hosseini-Khah, Zhoobin Kalantari, Mehdi Jahandar, Forouzan Sadeghimahalli, Sakineh Shafia   +5 more
doaj  

Effect of the BDNF-TrkB Signalling Pathway on the Synaptic Plasticity of Hippocampal Neurons in Epileptic Rats

, 2023
Yu lu Geng, Dian feng Liu, Hai Li, Xiao ping Zhu, Wen zhi Ren, Fu shi Quan   +5 more
openalex   +1 more source

Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]

, 2011
Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell, C. J. Rogers, Chao, Clement, de Paz, Dechant, Faham, Gama, Huang, K. C. Garcia, Keiser, Khunrae, Kim, L. C. Hsieh-Wilson, Lowes, Mukai, Mulloy, Oohira, P. M. Clark, Pellegrini, Petitou, R. Abrol, Raman, Rapp, Rawat, Raza, Roux, S. E. Tully, Schlessinger, Shelton, Shipp, Spivak-Kroizman, Strom, Sugahara, Sweeney, Tully, Tully, Vaudry, W. A. Goddard, Zhang   +39 more
core   +2 more sources

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Myocardial Disorders in BDNF-Deficient Rats: Limited Recovery Post-Moderate Endurance Training

Diabetes, Metabolic Syndrome and Obesity
Norbert Grzelak,1 Dominik Kaczmarek,2 Krystian Marek Poziemba,2 Włodzimierz Mrówczyński1 1Department of Neurobiology, Poznań University of Physical Education, Poznań, Poland; 2Department of Physiology and Biochemistry, Pozna ...
Grzelak N, Kaczmarek D, Poziemba KM, Mrówczyński W   +3 more
doaj