Results 151 to 160 of about 220,963 (383)
BDNF Signaling and Pain Modulation
CellsBrain-derived neurotrophic factor (BDNF) is an important neuromodulator of nervous system functions and plays a key role in neuronal growth and survival, neurotransmission, and synaptic plasticity. The effects of BDNF are mainly mediated by the activation of tropomyosin receptor kinase B (TrkB), expressed in both the peripheral and central nervous ...
Mariacristina Mazzitelli +6 more
openaire +3 more sources
HuD Interacts with Bdnf mRNA and Is Essential for Activity-Induced BDNF Synthesis in Dendrites
PLOS ONE, 2015 Highly specific activity-dependent neuronal responses are necessary for modulating synapses to facilitate learning and memory. We present evidence linking a number of important processes involved in regulating synaptic plasticity, suggesting a mechanistic pathway whereby activity-dependent signaling, likely through protein kinase C (PKC)-mediated ...
Baoji Xu, Filip Vanevski
openaire +5 more sources
Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model
Advanced Science, EarlyView.Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis +7 more
wiley +1 more source
International Journal of Molecular Sciences, 2017 In addition to its well-established neurotrophic action, brain-derived neurotrophic factor (BDNF) also possesses other neuroprotective effects including anti-apoptosis, anti-oxidation, and suppression of autophagy. We have shown before that BDNF triggers
Shang-Der Chen +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich +8 more
wiley +1 more source
Journal of OphthalmologyBackground: Myopia significantly decreases the frequency and severity of diabetic retinopathy (DR). The proliferative form of this diabetic complication in the retina is known to be very uncommon in diabetic myopes.
I. M. Mikheytseva +4 more
doaj +1 more source
Biomolecules, 2019 The brain-derived neurotrophic factor (BDNF) was initially considered to be neuron-specific. Meanwhile, this neurotrophin is peripherally also secreted by skeletal muscle cells and increases due to exercise.
Marie-Lena Schmalhofer +19 more
doaj +1 more source
Purification and characterisation of a brain‐derived neurotrophic factor/ neurotrophin‐3 (BDNF/NT‐3) heterodimer [PDF]
, 1994 Stefan Jungbluth +2 more
openalex +1 more source
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. [PDF]
, 1990 Francisco Zafra +4 more
openalex +1 more source