Results 41 to 50 of about 196,397 (352)

Blood BDNF concentrations reflect brain-tissue BDNF levels across species [PDF]

The International Journal of Neuropsychopharmacology, 2010
Brain-derived neurotrophic factor (BDNF) is involved in synaptic plasticity, neuronal differentiation and survival of neurons. Observations of decreased serum BDNF levels in patients with neuropsychiatric disorders have highlighted the potential of BDNF as a biomarker, but so far there have been no studies directly comparing blood BDNF levels to brain ...
Klein, Anders B, Williamson, Rebecca, Santini, Martin A, Clemmensen, Christoffer, Ettrup, Anders, Rios, Maribel, Knudsen, Gitte M, Aznar, Susana   +7 more
openaire   +3 more sources

Safety and feasibility of Lin- cells administration to ALS patients : a novel view on humoral factors and miRNA profiles [PDF]

, 2018
Therapeutic options for amyotrophic lateral sclerosis (ALS) are still limited. Great hopes, however, are placed in growth factors that show neuroprotective abilities (e.g., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular
Baumert, Bartłomiej, Dulak, Józef, Gołąb-Janowska, Monika, Gródecka-Szwajkiewicz, Dorota, Kawa, Miłosz P., Kotowski, Maciej, Litwińska, Zofia, Machaliński, Bogusław, Nowacki, Przemysław, Peregud-Pogorzelski, Jarosław, Pius-Sadowska, Ewa, Sobuś, Anna, Stępniewski, Jacek   +12 more
core   +2 more sources

PTSD risk is associated with BDNF Val66Met and BDNF overexpression [PDF]

Molecular Psychiatry, 2013
Brain-derived neurotrophic factor (BDNF), which regulates neuronal survival, growth, differentiation and synapse formation, broadly regulates the stress response.1 A common single-nucleotide polymorphism in the BDNF gene (Val66Met) influences hippocampal volume,2 memory3 and appears related to susceptibility to a variety of neuropsychiatric disorders ...
L, Zhang, D M, Benedek, C S, Fullerton, R D, Forsten, J A, Naifeh, X X, Li, X Z, Hu, H, Li, M, Jia, G Q, Xing, K N, Benevides, R J, Ursano   +11 more
openaire   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

The Neurogenic Effects of Pasak bumi (Eurycoma longifolia Jack) and Seluang Fish (Rasbora spp.) in Malnutrition-Induced Rat

Folia Medica Indonesiana
Highlights: 1. This study analyzed the effects of using locally sourced pasak bumi extract and seluang fish on the parameters of neurogenesis in malnourished rat models. 2.
Didik Dwi Sanyoto, Triawanti Triawanti, Meitria Syahadatina Noor, Dimas Ikhsan Airlangga   +3 more
doaj   +1 more source

Transcranial Magnetic stimulation in Neurodegenerative Diseases: Basics and Clinical Applications

Acta Medica Alanya, 2021
Transcranial Magnetic Stimulation (rTMS) non-invasively modulates brain networks via stimulating relevant brain regions responsible for motor and cognitive functions.
Burak Yuluğ, Ahmet Aslan
doaj   +1 more source

Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]

, 2018
Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R, Fu, Yingjie, Huang, Lei, Li, Yong, Ma, Qingyi, Song, Minwoo A, Xiao, Daliao, Zhang, Lubo, Zhang, Peng   +8 more
core   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus Renders Neuroprotection through the Suppression of Hippocampal Apoptosis: An Experimental Animal Study

Brain Sciences, 2020
The core objective of this study was to determine the neuroprotective properties of deep brain stimulation of the pedunculopontine tegmental nucleus on the apoptosis of the hippocampus.
Chellappan Praveen Rajneesh, Tsung-Hsun Hsieh, Shih-Ching Chen, Chien-Hung Lai, Ling-Yu Yang, Hung-Yen Chin, Chih-Wei Peng   +6 more
doaj   +1 more source

Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy. [PDF]

, 2019
Cancer-related cognitive impairment (CRCI) adversely affects cancer patients. We had previously demonstrated that the BDNF Val66Met genetic polymorphism is associated with lower odds of subjective CRCI in the multitasking and verbal ability domains among
Beh, Sok Yuen, Chan, Alexandre, Chan, Jack Junjie, Chay, Wen Yee, Chu, Pat, Dent, Rebecca A, Foo, Koon Mian, Ho, Han Kiat, Jain, Amit, Khor, Chiea Chuen, Koo, Si-Lin, Lee, Guek Eng, Lim, Elaine H, Lim, Sheree Wan Ting, Loh, Kiley Wei-Jen, Ng, Raymond Chee Hui, Ng, Terence, Shwe, Maung, Tan, Chia Jie, Tan, Tira Jing Ying, Toh, Yi Long, Wong, Mabel, Yap, Yoon Sim, Yeo, Angie   +23 more
core   +1 more source