Results 81 to 90 of about 196,397 (352)

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death [PDF]

, 1997
Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant
Alcántara Horrillo, Soledad, Barbacid, Mariano, Frisén, Jonás, Río Fernández, José Antonio del, Silos-Santiago, Inmaculada, Soriano García, Eduardo   +5 more
core   +1 more source

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

Aging reduces motivation through decreased Bdnf expression in the ventral tegmental area [PDF]

, 2023
Hanyue Cecilia Lei, Kyle E. Parker, Chao‐Cheng Kuo, Carla M. Yuede, Jordan G. McCall, Shin‐ichiro Imai   +5 more
openalex   +1 more source

Physical Activity and Hippocampal Sub-Region Structure in Older Adults with Memory Complaints. [PDF]

, 2018
BackgroundPhysical activity (PA) plays a major role in maintaining cognition in older adults. PA has been shown to be correlated with total hippocampal volume, a memory-critical region within the medial temporal lobe (MTL).
Bookheimer, Susan, Burggren, Alison C, Dobkin, Bruce, Emerson, Natacha D, Lavretsky, Helen, Merrill, David A, Miller, Karen J, Rahi, Berna, Siddarth, Prabha, Small, Gary   +9 more
core   +1 more source

Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain

Advanced Materials, EarlyView.
A novel carbon quantum dots‐dissolvable microneedle, CQDs‐dMN system, enables painless delivery and real‐time tracking of HSV‐1. The HSV‐1 is labeled with fluorescent CQDs and delivered to the skin dermis, minimizing damage compared to traditional methods.
Yaxiu Feng, Xiong Wang, Cien Chen, Di Wang, Changshun Hou, Yiran Wang, Huan Hu, Peiran Chen, LeiYing Qin, Qianya Wan, Xi Yao, Ming‐Liang He   +11 more
wiley   +1 more source

BDNF level role in formation of cognitive violations at middle-aged persons

Фармакокинетика и Фармакодинамика, 2020
Relevance: the problem of cognitive violations at middle-aged persons with stenoziruyushchy atherosclerosis of brakhiotsefalny arteries and interrelation between the BDNF level and cognitive violation at this group of persons is considered. Materials and
E. G. Pepelyaev, V. A. Semenov, O. A. Gromova   +2 more
doaj   +1 more source

Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury. [PDF]

, 2017
The therapeutic benefit of cell transplantation has been assessed in a host of central nervous system (CNS) diseases, including disorders of the spinal cord such as traumatic spinal cord injury (SCI).
Charsar, Brittany A., Lepore, Angelo C., Urban, Mark W.   +2 more
core   +2 more sources

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Cognitive appraisal of environmental stimuli induces emotion-like states in fish [PDF]

, 2017
The occurrence of emotions in non-human animals has been the focus of debate over the years. Recently, an interest in expanding this debate to non-tetrapod vertebrates and to invertebrates has emerged. Within vertebrates, the study of emotion in teleosts
A Zayed, AI Faustino, D Nettle, DJ Anderson, ES Paul, G Leal, G Liebsch, GJ Quirk, J Ganz, J Ganz, J LeDoux, JA Russell, JA Russell, JE LeDoux, JE Ploski, JF Lopez-Olmeda, JM McNamara, KC Berridge, KC Berridge, KP Maruska, L Galhardo, LA O’Connell, LF Barrett, M Mendl, MA Vindas, MA Vindas, P Ekman, PC Trimmer, R Landgraf, RJ Dolan, S Millot, S Millot, SD Cardoso, SE Wendelaar Bonga, T Brosch, T Kawashima, TP Sheehan, TW Fawcett, WT Gibson, X Sun, Y Benjamini, Y Lin   +41 more
core   +5 more sources