Results 151 to 160 of about 28,367 (198)

Bedaquiline Resistance: Its Emergence, Mechanism, and Prevention

Clinical Infectious Diseases, 2018
Bedaquiline, a new antituberculosis drug, has already been used in >50 countries. The emergence of bedaquiline resistance is alarming, as it may result in the rapid loss of this new drug.
Thi Van Anh Nguyen, Richard M Anthony, Anne-Laure Bañuls   +2 more
exaly   +4 more sources

Variants in Bedaquiline-Candidate-Resistance Genes: Prevalence in Bedaquiline-Naive Patients, Effect on MIC, and Association with Mycobacterium tuberculosis Lineage [PDF]

Antimicrobial Agents and Chemotherapy, 2022
: Studies have shown that variants in bedaquiline-resistance genes can occur in isolates from bedaquiline-naive patients. We assessed the prevalence of variants in all bedaquiline-candidate-resistance genes in bedaquiline-naive patients, investigated the
Emmanuel Riviere, Lennert Verboven, Anzaan Dippenaar   +2 more
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Bedaquiline

Reactions Weekly
Jeremy Michael Burgess, Emma Whisman, Jordan DeWitt   +2 more
  +10 more sources

Clofazimine Exposure In Vitro Selects Efflux Pump Mutants and Bedaquiline Resistance [PDF]

Antimicrobial Agents and Chemotherapy, 2019
Six in vitro clofazimine-resistant spontaneous mutants obtained from a wild-type or pyrazinamide-resistant ATCC reference strain were selected to evaluate bedaquiline cross-resistance. The reverse was conducted for bedaquiline mutants.
Nabila Ismail, Remco P H Peters, Nazir Ismail   +2 more
exaly   +2 more sources

Bedaquiline and delamanid in tuberculosis

Expert Opinion on Pharmacotherapy, 2015
In recent years, a pressing need to develop new, effective and safe drugs against tuberculosis (TB) has continued. Poor adherence to a long therapeutic regimen against TB, intermittent drug use, errors in medical prescriptions, low quality of old TB drugs and ineffective TB control have led to the emergence of resistant TB.Two new drugs have gained ...
S. Esposito, S. Bianchini, F. Blasi
openaire   +3 more sources

Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity

Proceedings of the National Academy of Sciences of the United States of America
Bedaquiline is the cornerstone of a new regimen for the treatment of drug-resistant tuberculosis. However, its clinical use is threatened by the emergence of bedaquiline-resistant strains of Mycobacterium tuberculosis.
Chen-Yi Cheung, Paul H Edelstein, Gregory M Cook   +2 more
exaly   +4 more sources

Bedaquiline

Reactions Weekly, 2022
  +4 more sources

Bedaquiline

Annals of Pharmacotherapy, 2013
Objective: To review the chemistry, pharmacology, microbiology, pharmacokinetics, pharmacodynamics, clinical efficacy, safety, dosage, and administration of bedaquiline, a novel oral diarylquinoline antimycobacterial agent approved by the Food and Drug Administration for the treatment of adults with pulmonary multidrug-resistant tuberculosis (MDR-TB ...
Chahine, Elias B., Karaoui, Lamis R., Mansour, Hanine   +2 more
openaire   +3 more sources