Results 1 to 10 of about 42,053 (210)

Bioengineering Beige Adipose Tissue Therapeutics [PDF]

Frontiers in Endocrinology, 2015
Unlocking the therapeutic potential of brown/beige adipose tissue requires technological advancements that enable the controlled expansion of this uniquely thermogenic tissue. Transplantation of brown fat in small animal model systems has confirmed the expectation that brown fat expansion could possibly provide a novel therapeutic to combat obesity and
Kevin M. Tharp, Andreas Stahl
openalex   +4 more sources

Rutin Maintains the Thermogenic Phenotype of Beige Adipocytes and Concomitantly Suppresses Mitophagy Against Obesity in HFD Mice [PDF]

Metabolites
Background: The browning of white adipose tissue for thermogenesis is an effective strategy for combating obesity. The formation of beige adipocytes is reversible, making their maintenance a key therapeutic target.
Jianmei Li, Kexin Li, Shengnan Li, Jingxun Cui, Shuangying Zhou, Huiwen Wu   +5 more
doaj   +2 more sources

Reversing Pdgfrβ signaling restores metabolically active beige adipocytes by alleviating ILC2 suppression in aged and obese mice [PDF]

Molecular Metabolism
Objective: Platelet Derived Growth Factor Receptor Beta (Pdgfrβ) suppresses the formation of cold temperature-induced beige adipocytes in aged mammals.
Abigail M. Benvie, Daniel C. Berry
doaj   +2 more sources

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells [PDF]

PLoS ONE, 2012
Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect animals from cold and obesity. Rodents possess two types of UCP-1 positive brown adipocytes arising from distinct developmental lineages: "classical" brown adipocytes ...
Kosaku Shinoda, Haruya Ohno, Houchun Hu
exaly   +2 more sources

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis [PDF]

Cell, 2014
Jonathan Z Long, James P White, Katrin J Svensson   +2 more
exaly   +2 more sources

Protocol for stromal vascular fraction isolation from inguinal subcutaneous white adipose tissue and beige adipocyte differentiation [PDF]

STAR Protocols
Summary: Research on inducing beige adipocytes to combat obesity and its comorbidities is growing, with stromal vascular fraction (SVF) from white adipose tissue showing potential to differentiate into both white and beige adipocytes.
Qiqi Tang, Juan Xu, Xinyu Yang, Hanni Li, Lingdi Wang, Lu Zhu   +5 more
doaj   +2 more sources

Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology. [PDF]

Biol Sex Differ
Shashank CG, Mandali R, Wankhade UD.
europepmc   +2 more sources

Optimizing adipogenic cocktail composition to enhance beige adipogenesis and evaluate thermogenic potential in primary mouse subcutaneous fat cell cultures. [PDF]

Int J Obes (Lond)
Ma Y, Zhang Z, Ramos ET, Martin E, Gunukula R, Sprabary K, Jun H.   +6 more
europepmc   +3 more sources

Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime

Frontiers in Physiology, 2022
The intermittent fasting regimen (IFR) has been certified as an effective strategy for improving metabolism. But the underlying mechanism is still obscure. Beige induction in white adipose tissue (WAT) by IFR may account for this.
Xiaoxiao Jiang, Xiaoxiao Jiang, Xiaoxiao Jiang, Jun Lin, Meng Dong, Xiaomeng Liu, Yuanyuan Huang, Hanlin Zhang, Hanlin Zhang, Rongcai Ye, Rongcai Ye, Huiqiao Zhou, Huiqiao Zhou, Chunlong Yan, Shouli Yuan, Li Chen, Li Chen, Rui Jiang, Rui Jiang, Kexin Zheng, Wanzhu Jin, Wanzhu Jin   +21 more
doaj   +1 more source

Calcium burns beige

Journal of Experimental Medicine, 2022
In this issue of Journal of Experimental Medicine, Yin et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212491) discover that loss of FNIP1 is associated with browning of white adipose tissue, which they propose is driven by decreased calcium uptake into the ER.
Jakub Bunk, Lawrence Kazak
openaire   +2 more sources