Results 11 to 20 of about 42,152 (307)
Frontiers in Nutrition, 2023 IntroductionBrown adipose tissue (BAT) dissipates energy in the form of heat majorly via the mitochondrial uncoupling protein 1 (UCP1). The activation of BAT, which is enriched in the neck area and contains brown and beige adipocytes in humans, was ...
Boglárka Ágnes Vinnai +9 more
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FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes
Cell Reports, 2021 Summary: The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion of the FGF21 co-
Mohammad Abu-Odeh +18 more
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Frontiers in Cell and Developmental Biology, 2023 Introduction: White adipocytes store lipids, have a large lipid droplet and few mitochondria. Brown and beige adipocytes, which produce heat, are characterized by high expression of uncoupling protein (UCP) 1, multilocular lipid droplets, and large ...
Attila Vámos +18 more
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(20R)-panaxadiol improves obesity by promoting white fat beigeing
Frontiers in Pharmacology, 2023 Introduction: Obesity is an important cause of a range of metabolic diseases. However, the complex mechanisms of obesity and its related diseases make some weight loss methods ineffective or have safety issues.
Yuqian Lv +7 more
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Functional and Genetic Characterization of Porcine Beige Adipocytes
Cells, 2022 Beige adipocytes are a distinct type of fat cells with a thermogenic activity that have gained substantial attention as an alternative cellular anti-obesity target in humans.
Lilan Zhang +9 more
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Regulatory microRNAs in Brown, Brite and White Adipose Tissue
Cells, 2020 MicroRNAs (miRNAs) constitute a class of short noncoding RNAs which regulate gene expression by targeting messenger RNA, inducing translational repression and messenger RNA degradation.
Seley Gharanei +6 more
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Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo
Pharmaceuticals, 2022 Brown and beige adipocytes have multilocular lipid droplets, express uncoupling protein (UCP) 1, and promote energy expenditure. In rodents, when the stimulus of browning subsides, parkin-dependent mitophagy is activated and dormant beige adipocytes ...
Attila Vámos +9 more
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Genetically prolonged beige fat in male mice confers long-lasting metabolic health
Nature Communications, 2023 A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes. However, beige adipocytes quickly transition into white adipocytes upon removing stimuli.
Ruifan Wu +19 more
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Intricate Transcriptional Networks of Classical Brown and Beige Fat Cells
Frontiers in Endocrinology, 2015 Brown adipocytes are a specialized cell type that is critical for adaptive thermogenesis, energy homeostasis and metabolism. In response to cold, both classical brown fat and the newly identified beige or brite cells are activated by β-adrenergic ...
Sean Bong Lee +2 more
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