Distinct signaling and transcriptional pathways regulate peri-weaning development and cold-induced recruitment of beige adipocytes. [PDF]
Proc Natl Acad Sci U S A, 2020 Wu Y +3 more
europepmc +3 more sources
Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism. [PDF]
Genes Dev, 2019 Pearson S +7 more
europepmc +3 more sources
Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes. [PDF]
Nat Commun, 2022 AbstractThermogenic adipocytes generate heat to maintain body temperature against hypothermia in response to cold. Although tight regulation of thermogenesis is required to prevent energy sources depletion, the molecular details that tune thermogenesis are not thoroughly understood.
Han JS +14 more
europepmc +4 more sources
Diphyllin Improves High-Fat Diet-Induced Obesity in Mice Through Brown and Beige Adipocytes. [PDF]
Front Endocrinol (Lausanne), 2020 Duan YN +7 more
europepmc +2 more sources
Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo
Pharmaceuticals, 2022 Brown and beige adipocytes have multilocular lipid droplets, express uncoupling protein (UCP) 1, and promote energy expenditure. In rodents, when the stimulus of browning subsides, parkin-dependent mitophagy is activated and dormant beige adipocytes ...
Attila Vámos +9 more
doaj +1 more source
AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype. [PDF]
PLoS ONE, 2016 Beige adipocytes are special cells situated in the white adipose tissue. Beige adipocytes, lacking thermogenic cues, morphologically look quite similar to regular white adipocytes, but with a markedly different response to adrenalin.
Omar Abdul-Rahman +18 more
doaj +1 more source
Effects of exercise on brown and beige adipocytes. [PDF]
Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Physical exercise leads to beneficial effects in numerous tissues and organ systems and offers protection against obesity and type 2 diabetes. Recent studies have investigated the role of exercise on brown adipose tissue (BAT) and white adipose tissue (WAT), and have indicated marked adaptations to each tissue with exercise.
Dewal RS, Stanford KI.
europepmc +3 more sources
Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +6 more
doaj +1 more source
Mitochondria in White, Brown, and Beige Adipocytes [PDF]
Stem Cells International, 2016 Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown‐like (bAT) adipose tissues.
Miroslava Cedikova +7 more
openaire +3 more sources
Metabolic programming of a beige adipocyte phenotype by genistein [PDF]
Molecular Nutrition & Food Research, 2016 ScopePromoting the development of brown or beige adipose tissue may protect against obesity and related metabolic features, and potentially underlies protective effects of genistein in mice.Methods and resultsWe observed that application of genistein to 3T3‐L1 adipocytes changed the lipid distribution from large droplets to a multilocular distribution,
Sadat Abdulla Aziz +5 more
openalex +5 more sources