Results 21 to 30 of about 13,381 (238)
mTOR signaling in Brown and Beige adipocytes: implications for thermogenesis and obesity [PDF]
Nutrition & Metabolism, 2019 Brown and beige adipocytes are mainly responsible for nonshivering thermogenesis or heat production, despite the fact that they have distinguished features in distribution, developmental origin, and functional activation.
Yuqing Ye +3 more
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White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming [PDF]
PharmaceuticalsObesity has become a pandemic, as currently more than half a billion people worldwide are obese. The etiology of obesity is multifactorial, and combines a contribution of hereditary and behavioral factors, such as nutritional inadequacy, along with the influences of environment and reduced physical activity. Two types of adipose tissue widely known are
Stanislav Boychenko +3 more
openaire +4 more sources
Echinacoside Induces UCP1- and ATP-Dependent Thermogenesis in Beige Adipocytes via the Activation of Dopaminergic Receptors. [PDF]
J Microbiol Biotechnol, 2023 Haddish K, Yun JW.
europepmc +3 more sources
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming [PDF]
eLife, 2023 The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of adipocyte stem
Corey D Holman +8 more
doaj +2 more sources
Effects of exercise on brown and beige adipocytes. [PDF]
Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Physical exercise leads to beneficial effects in numerous tissues and organ systems and offers protection against obesity and type 2 diabetes. Recent studies have investigated the role of exercise on brown adipose tissue (BAT) and white adipose tissue (WAT), and have indicated marked adaptations to each tissue with exercise.
Dewal RS, Stanford KI.
europepmc +4 more sources
Aquaglyceroporins Are Differentially Expressed in Beige and White Adipocytes [PDF]
International Journal of Molecular Sciences, 2020 Browning of white adipocytes has been proposed as a powerful strategy to overcome metabolic complications, since brown adipocytes are more catabolic, expending energy as a heat form. However, the biological pathways involved in the browning process are still unclear.
Anna Gumà +9 more
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Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes. [PDF]
Nat Commun, 2022 AbstractThermogenic adipocytes generate heat to maintain body temperature against hypothermia in response to cold. Although tight regulation of thermogenesis is required to prevent energy sources depletion, the molecular details that tune thermogenesis are not thoroughly understood.
Han JS +14 more
europepmc +4 more sources
Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo
Pharmaceuticals, 2022 Brown and beige adipocytes have multilocular lipid droplets, express uncoupling protein (UCP) 1, and promote energy expenditure. In rodents, when the stimulus of browning subsides, parkin-dependent mitophagy is activated and dormant beige adipocytes ...
Attila Vámos +9 more
doaj +1 more source
Mitochondria in White, Brown, and Beige Adipocytes [PDF]
Stem Cells International, 2016 Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown‐like (bAT) adipose tissues.
Vaclav Babuska +7 more
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Chrna2-driven CRE Is Expressed in Beige Adipocytes
EndocrinologyAbstract Significant research interest has been focused on beige adipocytes, the activation of which improves glucose and lipid homeostasis, therefore representing new therapeutic opportunities for metabolic diseases. Various Cre/Lox-based strategies have been used to investigate the developmental history of beige adipocytes and how ...
Kezhou Zhu +5 more
openaire +3 more sources