Results 31 to 40 of about 8,288 (202)

Genetically prolonged beige fat in male mice confers long-lasting metabolic health

Nature Communications, 2023
A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes. However, beige adipocytes quickly transition into white adipocytes upon removing stimuli.
Ruifan Wu, Jooman Park, Yanyu Qian, Zuoxiao Shi, Ruoci Hu, Yexian Yuan, Shaolei Xiong, Zilai Wang, Gege Yan, Sang-Ging Ong, Qing Song, Zhenyuan Song, Abeer M. Mahmoud, Pingwen Xu, Congcong He, Robert W. Arpke, Michael Kyba, Gang Shu, Qingyan Jiang, Yuwei Jiang   +19 more
doaj   +1 more source

Adipocyte HDAC4 activation leads to beige adipocyte expansion and reduced adiposity [PDF]

Journal of Endocrinology, 2018
Numerous studies have suggested that beige adipocyte abundance is correlated with improved metabolic performance, but direct evidence showing that beige adipocyte expansion protects animals from the development of obesity is missing. Previously, we have described that the liver kinase b1 (LKB1) regulates beige adipocyte renaissance in subcutaneous ...
Paulo, Esther, Wu, Dongmei, Hecker, Peter, Zhang, Yun, Wang, Biao   +4 more
openaire   +4 more sources

The Beige Adipocyte as a Therapy for Metabolic Diseases [PDF]

International Journal of Molecular Sciences, 2019
Adipose tissue is traditionally categorized into white and brown relating to their function and morphology. The classical white adipose tissue builds up energy in the form of triglycerides and is useful for preventing fatigue during periods of low caloric intake and the brown adipose tissue more energetically active, with a greater number of ...
Fernando Lizcano
openalex   +5 more sources

ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation

Frontiers in Endocrinology, 2020
When exposed to cold temperatures, mice increase their thermogenic capacity by an expansion of brown adipose tissue mass and the formation of brite/beige adipocytes in white adipose tissue depots.
Sebastian Müller, Sebastian Müller, Sebastian Müller, Aliki Perdikari, Dianne H. Dapito, Wenfei Sun, Bernd Wollscheid, Miroslav Balaz, Christian Wolfrum   +8 more
doaj   +1 more source

Selective activation of PPARα maintains thermogenic capacity of beige adipocytes

iScience, 2023
Summary: Beige adipocytes are inducible thermogenic adipocytes used for anti-obesity treatment. Beige adipocytes rapidly lose their thermogenic capacity once external cues are removed.
Gentaro Egusa, Haruya Ohno, Gaku Nagano, Junji Sagawa, Hiroko Shinjo, Yutaro Yamamoto, Natsumi Himeno, Yoshimi Morita, Akinori Kanai, Ryuta Baba, Kazuhiro Kobuke, Kenji Oki, Masayasu Yoneda, Noboru Hattori   +13 more
doaj   +1 more source

Beige adipocytes contribute to breast cancer progression

Oncology Reports, 2020
Adipocytes are the main stromal cells in the mammary microenvironment, and crosstalk between adipocytes and breast cancer cells may play a critical and important role in cancer maintenance and progression. Tumor‑induced differentiation to beige/brown adipose tissue is an important contribution to the hypermetabolic state of breast cancer.
Gantov, Mariana, Pagnotta, Priscila Ayelén, Lotufo, Cecilia Maricel, Rindone, Gustavo Marcelo, Riera, Maria Fernanda, Calvo, Juan Carlos, Toneatto, Judith   +6 more
openaire   +4 more sources

Thermogenic adipose tissue in energy regulation and metabolic health

Frontiers in Endocrinology, 2023
The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat cells that regulate energy balance. Both adipocytes share common morphological,
Siwen Xue, Derek Lee, Daniel C. Berry
doaj   +1 more source

Aquaglyceroporins Are Differentially Expressed in Beige and White Adipocytes [PDF]

International Journal of Molecular Sciences, 2020
Browning of white adipocytes has been proposed as a powerful strategy to overcome metabolic complications, since brown adipocytes are more catabolic, expending energy as a heat form. However, the biological pathways involved in the browning process are still unclear.
Inês Vieira da Silva, Francisco Díaz-Sáez, António Zorzano, Anna Gumà, Marta Camps, Graça Soveral   +5 more
openaire   +3 more sources

A Smooth Muscle-Like Origin for Beige Adipocytes [PDF]

Cell Metabolism, 2014
Thermogenic UCP1-positive cells, which include brown and beige adipocytes, transform chemical energy into heat and increase whole-body energy expenditure. Using a ribosomal profiling approach, we present a comprehensive molecular description of brown and beige gene expression from multiple fat depots in vivo.
Long, Jonathan Z., Svensson, Katrin J., Tsai, Linus, Zeng, Xing, Roh, Hyun C., Kong, Xingxing, Rao, Rajesh R., Lou, Jesse, Lokurkar, Isha, Baur, Wendy, Castellot, John J., Rosen, Evan D., Spiegelman, Bruce M.   +12 more
openaire   +2 more sources

Fighting obesity by targeting factors regulating beige adipocytes. [PDF]

Curr Opin Clin Nutr Metab Care, 2018
The current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity.We outline recent studies revealing unrecognized mechanisms controlling beige adipocyte physiology, and summarize in particular those that underlie beige ...
McQueen AE, Koliwad SK, Wang JC.
europepmc   +7 more sources