Results 101 to 110 of about 172,738 (259)

Heart matters: How glucose‐ and lipid‐modulating drugs remodel epicardial adipose tissue accumulation, inflammatory patterns and browning

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot located between the myocardium and the visceral pericardium, exerting direct paracrine and vasocrine effects on the heart and coronary vessels. Under physiological conditions, EAT supports myocardial energy metabolism and thermoregulation through fatty acid supply and
Elisabeth Heuboeck, Charnkamal Singh Bhogal, Markus Mandl   +2 more
wiley   +1 more source

Mouse vascularized adipose spheroids: an organotypic model for thermogenic adipocytes

Frontiers in Endocrinology
Adipose tissues, particularly beige and brown adipose tissue, play crucial roles in energy metabolism. Brown adipose tissues’ thermogenic capacity and the appearance of beige cells within white adipose tissue have spurred interest in their metabolic ...
Laura Ingeborg Davidsen, Carolina E. Hagberg, Victor Goitea, Victor Goitea, Stine Meinild Lundby, Steen Larsen, Morten Frendø Ebbesen, Natasha Stanic, Hande Topel, Hande Topel, Jan-Wilhelm Kornfeld, Jan-Wilhelm Kornfeld   +11 more
doaj   +1 more source

Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes. [PDF]

, 2019
Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the roles of specific cell types in the metabolic response to IL10 remain to ...
Ahn, In Sook, Arneson, Douglas, Diamante, Graciel, Feng, An-Chieh, Hart, Sydney K, Lee, Stephen D, Rajbhandari, Abha K, Rajbhandari, Prashant, Reue, Karen, Santos, Luis C, Smale, Stephen T, Thomas, Brandon J, Tontonoz, Peter, Vergnes, Laurent, Yang, Xia, Zaghari, Nima   +15 more
core   +1 more source

Metabolic programming of a beige adipocyte phenotype by genistein [PDF]

, 2017
Scope Promoting the development of brown or beige adipose tissue may protect against obesity and related metabolic features, and potentially underlies protective effects of genistein in mice.
Anupongsanugool, Barbatelli, Couteur, der Lans, Elabd, Green, Green, Hargreaves, Harms, Himms-Hagen, Ions, Kamiya, Kim, Kim, King, Lee, Lephart, Luo, Matsushita, Moisan, Niculescu, Ozasa, Penza, Prossnitz, Qiang, Rannikko, Sanchez-Gurmaches, Sanchez-Gurmaches, Seale, Seale, Takahashi, Torre-Villalvazo, Vitali, Wakeling, Wang, Wu, Xie, Yoneshiro, Zhang   +38 more
core   +1 more source

Magnetic resonance imaging detects white adipose tissue beiging in mice following PDE10A inhibitor treatment [PDF]

, 2023
Michal R. Tomaszewski, Xiangjun Meng, Hyking Haley, C. Meacham Harrell, Terrence McDonald, Corin O. Miller, Sean M. Smith   +6 more
openalex   +1 more source

On the occurrence of the snakefish Trachinocephalus myops (Aulopiformes: Synodontidae) in the Azores archipelago

Journal of Fish Biology, EarlyView.
Abstract The snakefish Trachinocephalus myops is an Atlantic species distributed in tropical and temperate coastal waters on sandy substrates. This study reports the validated record of an adult T. myops in the Azores archipelago caught by a fisherman at Faial Island.
Iryna Hulevata, Filipe M. Porteiro, Eva Giacomello, Diana Catarino   +3 more
wiley   +1 more source

Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease

Molecular Metabolism, 2020
Objective: Discoidin domain receptor 1 (DDR1) is a collagen binding receptor tyrosine kinase implicated in atherosclerosis, fibrosis, and cancer. Our previous research showed that DDR1 could regulate smooth muscle cell trans-differentiation, fibrosis and
Marsel Lino, David Ngai, Alison Liu, Amanda Mohabeer, Cameron Harper, Laura-lee Caruso, Stephanie A. Schroer, Fred Fu, Trevor McKee, Adria Giacca, Minna Woo, Michelle P. Bendeck   +11 more
doaj   +1 more source

Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor y (PPARy) in the Conversion of White-to-brown Adipocytes [PDF]

, 2017
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor and a master regulator of adipogenesis. Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is an inducible enzyme that couples with cyclooxygenase-2 for the ...
Arroyo, Vicente, Clària i Enrich, Joan, García-Alonso, Verónica, González Périz, Ana, López Vicario, Cristina, Morán-Salvador, Eva, Párrizas, Marcelina, Rius, Bibiana, Titos Rodríguez, Esther, Werz, Oliver   +9 more
core   +1 more source

Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα

Genes & Development, 2016
In this study, Yan et al. use a mouse model to show that loss of folliculin (FLCN), which forms a repressor complex with AMPK, results in a complete metabolic reprogramming of adipose tissues, resulting in enhanced oxidative metabolism.
Ming Yan, É. Audet-Walsh, Sanaz Manteghi, C. Dufour, Benjamin Walker, M. Baba, J. St-Pierre, V. Giguère, A. Pause   +8 more
semanticscholar   +1 more source

The skeletal muscle–adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management

Experimental Physiology, EarlyView.
Abstract The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise‐induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism.
Yuhui Su, Na Liu, Yang Liu, Yiqun Sun, Yike Jiao   +4 more
wiley   +1 more source