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The Role of Thermogenic Fat Tissue in Energy Consumption

Current Issues in Molecular Biology, 2022
Mammalian adipose tissues are broadly divided into white adipose tissue (WAT) and thermogenic fat tissue (brown adipose tissue and beige adipose tissue).
Masato Horino, Kenji Ikeda, Tetsuya Yamada   +2 more
doaj   +1 more source

Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues

Frontiers in Endocrinology, 2022
Obesity is defined as overaccumulation of white adipose tissue in the body, mainly under the skin (subcutaneous adiposity) or in the abdominal cavity (visceral adiposity).
Ruping Pan, Yong Chen, Yong Chen, Yong Chen   +3 more
doaj   +1 more source

“Beige” Cross Talk Between the Immune System and Metabolism

Frontiers in Endocrinology, 2019
With thymic senescence the epithelial network shrinks to be replaced by adipose tissue. Transcription factor TBX-1 controls thymus organogenesis, however, the same TBX-1 has also been reported to orchestrate beige adipose tissue development.
Krisztina Banfai, Krisztina Banfai, David Ernszt, David Ernszt, Attila Pap, Peter Bai, Peter Bai, Peter Bai, Peter Bai, Kitti Garai, Kitti Garai, Djeda Belharazem, Judit E. Pongracz, Judit E. Pongracz, Krisztian Kvell, Krisztian Kvell   +15 more
doaj   +1 more source

Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation

Frontiers in Cell and Developmental Biology, 2020
Adipose progenitor cells, or preadipocytes, constitute a small population of immature cells within the adipose tissue. They are a heterogeneous group of cells, in which different subtypes have a varying degree of commitment toward diverse cell fates ...
Iryna Pyrina, Kyoung-Jin Chung, Zoi Michailidou, Michael Koutsilieris, Triantafyllos Chavakis, Triantafyllos Chavakis, Triantafyllos Chavakis, Antonios Chatzigeorgiou, Antonios Chatzigeorgiou   +8 more
doaj   +1 more source

Thermal stress induces glycolytic beige fat formation via a myogenic state. [PDF]

, 2019
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue.
A Jaworski, AA Lans van der, Andrew Brack, Annarita Scaramozza, C Trapnell, Carlos Henrique Sponton, DC Berry, ES Bachman, H Ohno, J Nedergaard, J Sanchez-Gurmaches, J Wu, JR Arch, JZ Long, K Ikeda, K Nishijo, K Shinoda, Kazuki Tajima, Kenji Ikeda, Kosaku Shinoda, Kyeongkyu Kim, L Kazak, L Vishvanath, L Ye, LZ Sharp, M Razzoli, ME Lidell, MJ Hanssen, ML Gantner, MS Rodeheffer, P Cohen, P Seale, Qiang Wang, S Collins, S Heinz, S Jung, S Kajimura, S Tripathi, Shingo Kajimura, T Buch, T Yoneshiro, Takeshi Yoneshiro, VK Mootha, Y Hasegawa, YH Lee, YH Tseng, Yong Chen, Zachary Brown, ZF Yang   +48 more
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Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism. [PDF]

, 2019
Prolonged cold exposure stimulates the recruitment of beige adipocytes within white adipose tissue. Beige adipocytes depend on mitochondrial oxidative phosphorylation to drive thermogenesis.
Lee, Sanghoon, Loft, Anne, Mandrup, Susanne, Pearson, Stephanie, Rajbhandari, Prashant, Simcox, Judith, Tontonoz, Peter, Villanueva, Claudio J   +7 more
core   +3 more sources

MicroRNA-33 Inhibits Adaptive Thermogenesis and Adipose Tissue Beiging [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2021
Objective: Recent studies have identified key transcriptional regulators of brown adipose tissue (BAT) differentiation and function, but posttranscriptional control of this network by microRNAs remains incompletely understood.
Milessa Silva Afonso, Narendra Verma, Coen van Solingen, Yannick Cyr, Monika Sharma, Luce Perie, Emma M. Corr, Martin Schlegel, Lianne C. Shanley, Daniel Peled, Jenny Y. Yoo, Ann Marie Schmidt, Elisabetta Mueller, Kathryn J. Moore   +13 more
openaire   +2 more sources

Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4. [PDF]

, 2017
Uncoupling protein 1+ beige adipocytes are dynamically regulated by environment in rodents and humans; cold induces formation of beige adipocytes, whereas warm temperature and nutrient excess lead to their disappearance. Beige adipocytes can form through
Chawla, Ajay, Huang, Wendong, Paulo, Esther, Wang, Biao, Wang, Yangmeng, Wu, Dongmei, Wu, Yixuan   +6 more
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Pioglitazone does not synergize with mirabegron to increase beige fat or further improve glucose metabolism

JCI Insight, 2021
BACKGROUND Beige and brown adipose tissue (BAT) are associated with improved metabolic homeostasis. We recently reported that the β3-adrenergic receptor agonist mirabegron induced beige adipose tissue in obese insulin-resistant subjects, and this was ...
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L. Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E. Dupont-Versteegden, Philip A. Kern   +12 more
doaj   +1 more source

PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. [PDF]

, 2019
(1) Background: Paraoxonase 2 (PON2) is a ubiquitously expressed protein localized to endoplasmic reticulum and mitochondria. Previous studies have shown that PON2 exhibits anti-oxidant and anti-inflammatory functions, and PON2-deficient (PON2-def) mice ...
Fogelman, Alan M, Lusis, Aldons J, Meng, Yonghong, Reddy, Srinivasa T, Reue, Karen, Sallam, Tamer, Shih, Diana M, Shu, Michelle L, Tontonoz, Peter, Vergnes, Laurent   +9 more
core   +1 more source