Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues
Сахарный диабет, 2014 According to the International Diabetes Federation, 10.9 million people have diabetes mellitus (DM) in Russia; however, only up to 4 million are registered.
Ekaterina Olegovna Koksharova +3 more
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The great roundleaf bat (Hipposideros armiger) as a good model for cold-induced browning of intra-abdominal white adipose tissue. [PDF]
PLoS ONE, 2014 Inducing beige fat from white adipose tissue (WAT) is considered to be a shortcut to weight loss and increasingly becoming a key area in research into treatments for obesity and related diseases.
Yao Wang +9 more
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PexRAP inhibits PRDM16-mediated thermogenic gene expression [PDF]
, 2017 How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Dean, John M +8 more
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FBF1 Deficiency Promotes Beiging and Healthy Expansion of White Adipose Tissue [PDF]
SSRN Electronic Journal, 2021 Preadipocytes dynamically produce sensory cilia. However, the role of primary cilia in preadipocyte differentiation and adipose homeostasis remains poorly understood. We previously identified transition fiber component FBF1 as an essential player in controlling selective cilia import.
Zhang, Yingyi +15 more
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Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone
Biology, 2019 While it is now understood that the proper expansion of adipose tissue is critically important for metabolic homeostasis, it is also appreciated that adipose tissues perform far more functions than simply maintaining energy balance.
Kevin J. Phillips
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Beta‐adrenergic agonist induces unique transcriptomic signature in inguinal white adipose tissue
Physiological Reports, 2023 Activation of thermogenic adipose tissue depots has been linked to improved metabolism and weight loss. To study the molecular regulation of adipocyte thermogenesis, we performed RNA‐Seq on brown adipose tissue (BAT), gonadal white adipose tissue (gWAT),
Henry A. Paz +5 more
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Evaluation of markers of beige adipocytes in white adipose tissue of the mouse [PDF]
Nutrition & Metabolism, 2016 There is a growing interest in exploiting the induction of beige or "brite" (brown in white) adipocytes (beigeing) to combat obesity and its comorbidities. However, there is some uncertainty regarding the best markers to evaluate the occurrence or magnitude of beigeing in white adipose tissue in the mouse model.We evaluated the transcript expression of
Garcia, Rolando A. +2 more
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Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway
Cell Reports, 2018 Summary: Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity to orchestrate substantial energy metabolism and counteract obesity.
Xing Zhang +16 more
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Chronic l-menthol-induced browning of white adipose tissue hypothesis: A putative therapeutic regime for combating obesity and improving metabolic health [PDF]
, 2016 Obesity constitutes a serious global health concern reaching pandemic prevalence rates. The existence of functional brown adipose tissue (BAT) in adult humans has provoked intense research interest in the role of this metabolically active tissue in whole-
Andrade, Cl��udia Marlise Balbinotti +11 more
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Brown and beige adipose tissues
Journal of Applied Physiology, 2018 With the recent rediscovery of brown fat in adult humans, our outlook on adipose tissue biology has undergone a paradigm shift. While we attempt to identify, recruit, and activate classic brown fat stores in humans, identification of beige fat has also raised the possibility of browning our white fat stores.
Chechi, Kanta +2 more
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