Results 61 to 70 of about 15,100 (167)

Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling

Nature Communications, 2022
AbstractAlthough inflammation plays critical roles in the development of atherosclerosis, its regulatory mechanisms remain incompletely understood. Perivascular adipose tissue (PVAT) has been reported to undergo inflammatory changes in response to vascular injury.
Yusuke Adachi, Kazutaka Ueda, Seitaro Nomura, Kaoru Ito, Manami Katoh, Mikako Katagiri, Shintaro Yamada, Masaki Hashimoto, Bowen Zhai, Genri Numata, Akira Otani, Munetoshi Hinata, Yuta Hiraike, Hironori Waki, Norifumi Takeda, Hiroyuki Morita, Tetsuo Ushiku, Toshimasa Yamauchi, Eiki Takimoto, Issei Komuro   +19 more
openaire   +3 more sources

Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]

, 2019
Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang, Chang, Hsin-Yi, Ikeda, Kenji, Ishihama, Yasushi, Jun, Heejin, Kajimura, Shingo, Oguri, Yasuo, Tajima, Kazuki, Wu, Jun, Yoneshiro, Takeshi   +9 more
core  

Tissue‐Specific Extracellular Vesicles Enriched From Circulation: Exploring the Liquid Biopsy Perspective

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Extracellular vesicles (EVs) released from tissues can be found in human biofluids. EVs reflect the phenotypic state of their cell of origin, carrying informative molecular biomarkers within and between tissues, and represent a promising target for liquid biopsy.
Biancamaria Pierri, Erez Eitan, Kenneth W. Witwer, Diane B. Re, Andrea A. Baccarelli, Haotian Wu   +5 more
wiley   +1 more source

Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions [PDF]

, 2015
A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes.
Arble, Deanna M, Bass, Joseph, Behn, Cecilia Diniz, Butler, Matthew P, Challet, Etienne, Czeisler, Charles, Depner, Christopher M, Elmquist, Joel, Franken, Paul, Grandner, Michael A, Hanlon, Erin C, Joyner, Michael J, Karatsoreos, Ilia, Keene, Alex C, Kern, Philip A, Klein, Samuel, Morris, Christopher J, Pack, Allan I, Panda, Satchidananda, Ptacek, Louis J, Punjabi, Naresh M, Sassone-Corsi, Paolo, Saxena, Richa, Scheer, Frank A, Scheer, Frank A, Seaquest, Elizabeth R, Thimgan, Matthew S, Van Cauter, Eve, Wright, Kenneth P   +28 more
core   +4 more sources

Stem Cell Therapy for Inflammatory Diseases: Progress, Challenges, and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Stem cells offer multifaceted therapeutic approaches for inflammatory diseases, each exhibiting distinct therapeutic properties. Hematopoietic stem cells, primarily through hematopoietic stem cell transplantation (HSCT), can effectively remodel the immune environment, showing particular promise in treating genetically linked cases.
Chen Wu, Zhi‐Ping Jin, Shu‐Qiang Weng, Ji‐Min Zhu, Ling Dong   +4 more
wiley   +1 more source

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

Cell Reports, 2013
The phenomenon of white fat "browning," in which certain white adipose tissue depots significantly increase gene expression for the uncoupling protein UCP1 and thus supposedly acquire thermogenic, fat-burning properties, has attracted considerable attention.
Irina G. Shabalina, Natasa Petrovic, Jasper M.A. de Jong, Anastasia V. Kalinovich, Barbara Cannon, Jan Nedergaard   +5 more
openaire   +3 more sources

Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. [PDF]

, 2020
Cold stimuli and the subsequent activation of β-adrenergic receptor (β-AR) potently stimulate adipose tissue thermogenesis and increase whole-body energy expenditure.
Ferro, Marc D, Ikeda, Kenji, Kajimura, Shingo, Oguri, Yasuo, Poon, Ada SY, Tajima, Kazuki, Tanabe, Yuji, Thomson, Ella A, Yoneshiro, Takeshi   +8 more
core  

Metabolic programming of a beige adipocyte phenotype by genistein [PDF]

, 2017
Scope Promoting the development of brown or beige adipose tissue may protect against obesity and related metabolic features, and potentially underlies protective effects of genistein in mice.
Anupongsanugool, Barbatelli, Couteur, der Lans, Elabd, Green, Green, Hargreaves, Harms, Himms-Hagen, Ions, Kamiya, Kim, Kim, King, Lee, Lephart, Luo, Matsushita, Moisan, Niculescu, Ozasa, Penza, Prossnitz, Qiang, Rannikko, Sanchez-Gurmaches, Sanchez-Gurmaches, Seale, Seale, Takahashi, Torre-Villalvazo, Vitali, Wakeling, Wang, Wu, Xie, Yoneshiro, Zhang   +38 more
core   +1 more source

Acyl‐CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Acyl‐CoA binding protein plays a vital role in lipid metabolism by mediating the intracellular flux and utilization of long‐chain acyl‐CoAs. We generated an adipocyte‐wide ACBP knockout mouse and a brown adipose tissue‐specific ACBP knockout mouse to investigate ACBP function in adipose tissue.
M. F. Nørremark, R. Petersen, P. M. M. Ruppert, E. S. Jul, T. K. Doktor, R. Nielsen, J. F. Kappel, S. Larsen, J. W. Kornfeld, S. Mandrup, B. S. Andresen, J. Havelund, D. Neess, N. J. Færgeman   +13 more
wiley   +1 more source

Metabolic heterogeneity of activated beige/brite adipocytes in inguinal adipose tissue [PDF]

Scientific Reports, 2017
AbstractSustained β3 adrenergic receptor (ADRB3) activation simultaneously upregulates fatty acid synthesis and oxidation in mouse brown, beige, and white adipose tissues; however, the cellular basis of this dual regulation is not known. Treatment of mice with the ADRB3 agonist CL316,243 (CL) increased expression of fatty acid synthase (FASN) and ...
Yun-Hee Lee, Sang-Nam Kim, Hyun-Jung Kwon, James G. Granneman   +3 more
openaire   +2 more sources