Results 71 to 80 of about 38,129 (248)
Sympathetic nerve innervation is required for beigeing in white fat [PDF]
Physiological Reports, 2019 It is increasingly recognized that activation of beige adipocyte thermogenesis by pharmacological or genetic approaches increases energy expenditure and alleviates obesity. Sympathetic nervous system (SNS) directly innervating brown adipose tissue (BAT) and white adipose tissue (WAT) plays a key role in promoting nonshivering thermogenesis.
Bingzhong Xue +4 more
openaire +4 more sources
Adipose tissue browning for the treatment of obesity and metabolic diseases [PDF]
CellR4, 2020 Adipose tissue is the most abundant endocrine organ in humans with an important influence on many events throughout life. Many studies that highlight the different phenotypic characteristics of fat cells in adults are becoming more frequent. Perhaps, one
F. Arroyave, D. Montaño, F. Lizcano
doaj +1 more source
The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms [PDF]
, 2015 Objectives: The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.
Clark, S. +10 more
core +3 more sources
Going immune on beige fat [PDF]
Science-Business eXchange, 2014 Two independent teams at UCSF and Harvard have found an immune-regulated pathway for beige fat formation and a hormone, METRNL, that activates it. Ember Therapeutics has an option to license the molecule, which could represent a new way to treat obesity.
openaire +2 more sources
Notch signaling regulates adipose browning and energy metabolism [PDF]
, 2014 Beige adipocytes in white adipose tissue (WAT) are similar to classical brown adipocytes in that they can burn lipids to produce heat. Thus, an increase in beige adipocyte content in WAT browning would raise energy expenditure and reduce adiposity.
Bi, Pengpeng +10 more
core +5 more sources
Glucocorticoid Receptor and Adipocyte Biology. [PDF]
, 2018 Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Harris, Charles A +2 more
core +2 more sources
Brown and Beige Fat: Molecular Parts of a Thermogenic Machine [PDF]
Diabetes, 2015 The epidemic of obesity and type 2 diabetes has increased interest in pathways that affect energy balance in mammalian systems. Brown fat, in all of its dimensions, can increase energy expenditure through the dissipation of chemical energy in the form of heat, using mitochondrial uncoupling and perhaps other pathways.
Bruce M. Spiegelman, Paul Cohen
openaire +3 more sources
Metabolic regulation and the anti-obesity perspectives of human brown fat
Redox Biology, 2017 Activation of brown adipose tissue (BAT) in adult humans increase glucose and fatty acid clearance as well as resting metabolic rate, whereas a prolonged elevation of BAT activity improves insulin sensitivity.
Camilla Scheele, Søren Nielsen
doaj +1 more source
LIGHT/TNFSF14 signaling attenuates beige fat biogenesis [PDF]
The FASEB Journal, 2018 The physiologic signals that regulate beige adipogenesis remain incompletely understood, especially those that limit browning and prevent overexpenditure of energy. In this study, the TNF family member cytokine lymphotoxin-like inducible protein that competes with glycoprotein D for herpesvirus entry on T cells (LIGHT), also known as TNF super family ...
Hongxiang Sun +9 more
openaire +3 more sources
Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization [PDF]
, 2016 Scope: Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown adipose tissue dissipating energy to produce heat in mammals.
Bao, Yong P. +10 more
core +1 more source