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The Impact of <i>UGT1A1</i> Genetic Variability on Enzyme Expression in Liver Pathology. [PDF]
Szeląg-Pieniek S +5 more
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Commentary: Disulfidptosis-related gene signatures as prognostic biomarkers and predictors of immunotherapy response in HNSCC. [PDF]
Xue J, Xue C, Yin Q, Chen L, Wang M.
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Epigenetic Regulation Through Histone Deacetylation: Implications and Therapeutic Potential in Hepatocellular Carcinoma. [PDF]
Sadia K +9 more
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Design, synthesis, biological and in silico evaluation of 3‑carboxy‑coumarin sulfonamides as potential antiproliferative agents targeting HDAC6. [PDF]
Madrigal-Angulo JL +8 more
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Histone and non-histone (de)acetylation impact on the blood-brain barrier. [PDF]
Melo M +3 more
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Simple and Efficient Synthesis of Belinostat
Synthetic Communications, 2010A novel synthesis of belinostat (1) starting from 3-nitrobenzaldehyde has been developed. The key step in this sequence involves the conversion of (2E)-3-(3-aminophenyl)acrylic acid methyl ester to (2E)-3-(3-chlorosulfonylphenyl)acrylic acid methyl ester via diazotization and sulfonylation.
Lei Yang, Xiaowen Xue, Yihua Zhang
exaly +3 more sources
UGT genotyping in belinostat dosing [PDF]
Certain genetic polymorphisms of UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) can reduce gene expression (*28, *60, *93) or activity (*6), thereby altering the pharmacokinetics, pharmacodynamics, and the risk of toxicities of UGT1A1 substrates, of which irinotecan is a widely-described example.
Andrew K L Goey
exaly +3 more sources

