Results 151 to 160 of about 4,340 (195)

The Impact of <i>UGT1A1</i> Genetic Variability on Enzyme Expression in Liver Pathology. [PDF]

open access: yesGenes (Basel)
Szeląg-Pieniek S   +5 more
europepmc   +1 more source

Epigenetic Regulation Through Histone Deacetylation: Implications and Therapeutic Potential in Hepatocellular Carcinoma. [PDF]

open access: yesCells
Sadia K   +9 more
europepmc   +1 more source

Design, synthesis, biological and in silico evaluation of 3‑carboxy‑coumarin sulfonamides as potential antiproliferative agents targeting HDAC6. [PDF]

open access: yesBiomed Rep
Madrigal-Angulo JL   +8 more
europepmc   +1 more source

Histone and non-histone (de)acetylation impact on the blood-brain barrier. [PDF]

open access: yesFluids Barriers CNS
Melo M   +3 more
europepmc   +1 more source

Simple and Efficient Synthesis of Belinostat

Synthetic Communications, 2010
A novel synthesis of belinostat (1) starting from 3-nitrobenzaldehyde has been developed. The key step in this sequence involves the conversion of (2E)-3-(3-aminophenyl)acrylic acid methyl ester to (2E)-3-(3-chlorosulfonylphenyl)acrylic acid methyl ester via diazotization and sulfonylation.
Lei Yang, Xiaowen Xue, Yihua Zhang
exaly   +3 more sources

UGT genotyping in belinostat dosing [PDF]

open access: yesPharmacological Research, 2016
Certain genetic polymorphisms of UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) can reduce gene expression (*28, *60, *93) or activity (*6), thereby altering the pharmacokinetics, pharmacodynamics, and the risk of toxicities of UGT1A1 substrates, of which irinotecan is a widely-described example.
Andrew K L Goey
exaly   +3 more sources

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