Results 21 to 30 of about 4,340 (195)

Critical appraisal of belinostat in the management of T-cell lymphoma – patient considerations

Blood and Lymphatic Cancer: Targets and Therapy, 2015
Andrew Bodiford,1 Mahsa S Talbott,1 Nishitha M Reddy,2 1Department of Pharmacy, 2Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA Abstract: The histone deacetylase inhibitor (HDACi ...
Bodiford A, Talbott MS, Reddy NM
doaj   +1 more source

Sustained Belinostat‐Induced Metabolic Response and Tolerability in Heavily Pretreated Relapsed/Refractory Angioimmunoblastic T‐Cell Lymphoma: A Case Report

Clinical Case Reports
Angioimmunoblastic T‐cell lymphoma (AITL), a rare and aggressive subtype of peripheral T‐cell lymphoma (PTCL), often demonstrates resistance to standard therapies.
Vassiliki Labropoulou, Evgenia Verigou, Eleni P. Kourea, Maria Liga, Dimitrios Tsokanas, Krisela‐Christina Valera, Alexandros Spyridonidis   +6 more
doaj   +2 more sources

Polymorphic Forms Of Belinostat and Processes For Preparation Thereof

, 2016
The present invention relates to the polymorphic forms of Belinostat. The invention also relates to the process for the preparation of the polymorphic forms of Belinostat. This invention further relates to pharmaceutical composition of said polymorphic forms of Belinostat and use thereof in the treatment of a patient in need thereof.
Lahiri, S., Singh, G., Cabri W
openaire   +2 more sources

Repurposing Belinostat for Alleviation of Atopic Dermatitis [PDF]

Dermatology and Therapy, 2021
Atopic dermatitis (AD) is a highly prevalent chronic inflammatory skin disease that is characterized by intense pruritus, seriously affecting patients' quality of life. Its pathophysiology, which involves both the adaptive and innate immune responses as well as skin barrier defects, is still poorly understood. We recently identified a microRNA, miR-335,
Shan Quah, Gowtham Subramanian, Prabha Sampath   +2 more
openaire   +2 more sources

Cinnamic-Hydroxamic-Acid Derivatives Exhibit Antibiotic, Anti-Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid-Associated Protein HU. [PDF]

Adv Sci (Weinh)
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Chen H, Xu Y, Xiong Z, Wang H, Wang X, Kang Y, Wang Z, Zeng X, Liu Y, Zheng Y, Chen W, Li M, Hu Z, Xu C, Wu Y, Wang Y, Yuan Z, Yuan S, Liu H, Matthews S, Qiao N, Li Y, Liu B.   +22 more
europepmc   +2 more sources

Drug Monographs: Belinostat and Idelalisib [PDF]

Hospital Pharmacy, 2014
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases ...
Whitney L, Piper, J Aubrey, Waddell, Dominic A, Solimando   +2 more
openaire   +2 more sources

Complete hematologic response after belinostat treatment and allogeneic stem cell transplantation for multiple relapsed/refractory angioimmunoblastic T‐cell lymphoma: A case report

Clinical Case Reports, 2023
Key Clinical Message This case report highlights the potential of belinostat for the treatment of relapsed/refractory peripheral T‐cell lymphomas, for which effective therapies are still scarce.
Vincent Camus, Pascaline Etancelin, Fanny Drieux, Elena‐Liana Veresezan, Jean‐Michel Picquenot, Dominique Penther, Mathieu Viennot, Philippe Ruminy, Nathalie Contentin, Emilie Lemasle, Stéphane Leprêtre, Sydney Dubois, Juliette Penichoux, Aspasia Stamatoullas, Alexandra Zduniak, Hélène Lanic, Fabrice Jardin   +16 more
doaj   +1 more source

The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo

Journal of Translational Medicine, 2007
Background Treatment options for patients with recurrent superficial bladder cancer are limited, necessitating aggressive exploration of new treatment strategies that effectively prevent recurrence and progression to invasive disease.
Liebes Leonard, Chiriboga Luis, Yee Herman, Yoon Joanne, Buckley Michael T, Ara Gulshan, Qian Xiaozhong, Bajorin Dean F, Sun Tung-Tien, Wu Xue-Ru, Osman Iman   +10 more
doaj   +1 more source

Belinostat for Relapsed or Refractory Peripheral T-Cell Lymphoma [PDF]

Journal of the Advanced Practitioner in Oncology, 2016
The PTCLs represent a rare and aggressive subgroup of NHLs that do not respond favorably to traditional chemotherapies. Since the majority of patients with PTCL experience disease relapse or disease that is refractory to previous agents, the continued development of novel targeted therapies is critical and necessary to improve outcomes in this ...
Katelyn, Hood, Arpita, Shah
openaire   +2 more sources

Histone Deacetylase Inhibitors Dose-Dependently Switch Neutrophil Death from NETosis to Apoptosis

Biomolecules, 2019
Acetylation is an important post translational modification of histone that plays a role in regulation of physiological and pathological process in the body.
Hussein J. Hamam, Nades Palaniyar
doaj   +1 more source