Results 41 to 50 of about 4,340 (195)
Interactions between Bortezomib and Romidepsin and Belinostat in Chronic Lymphocytic Leukemia Cells [PDF]
Clinical Cancer Research, 2008 Abstract Purpose: The goal of this study was to characterize interactions between the proteasome inhibitor bortezomib and the histone deacetylase (HDAC) inhibitors (HDACI) romidepsin or belinostat in chronic lymphocytic leukemia (CLL) cells.
Yun, Dai +5 more
openaire +2 more sources
Recent Prospectives of Anticancer Histone Deacetylase Inhibitors [PDF]
Journal of Advanced Biomedical and Pharmaceutical Sciences, 2019 Histone deacetylases (HDACs) are common targets for cancer therapy as they are expressed in many forms of cancers; several research studies have been introduced discussing the design of small molecules that target this abnormal epigenetic changes ...
Shymaa Abbass +4 more
doaj +1 more source
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Pediatric Investigation, EarlyView.Pediatric nasal skull base tumors present diagnostic and therapeutic challenges due to their deep location, nonspecific symptoms, and the narrow nasal cavity in children. Although artificial intelligence (AI) and digital medicine have advanced early diagnosis, multidisciplinary treatment, and prognosis, their application in these rare tumors remains ...
Xiuping Wu +5 more
wiley +1 more source
Belinostat Is Active in Peripheral T-Cell Lymphoma [PDF]
Cancer Discovery, 2015 Abstract Belinostat induces durable responses and is well tolerated in patients with relapsed or refractory PTCL.
openaire +1 more source
Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.Tumour‐intrinsic DRAM1, induced by DNA damage and IFN‐γ, activates an autophagy/JAK‐STAT axis that recruits Tregs, causing CD8+ T cell exhaustion and establishing a self‐sustaining, immunotherapy‐resistant “cold” tumour microenvironment. Abstract Background DNA damage‐regulated autophagy modulator 1 (DRAM1) is a lysosomal protein involved in autophagy ...
Jinchun Wu +7 more
wiley +1 more source
Epigenetic Therapy with Belinostat Stabilizes Unresectable HCC [PDF]
Cancer Discovery, 2012 Abstract A phase I/II study in HCC shows that the HDAC inhibitor belinostat safely leads to disease stabilization.
openaire +1 more source
Belinostat-induces stabilization rather than expression of TAZ.
, 2013 Panel A. expression of TAZ in response to Belinostat (5 µM) measured quantitative PCR. Panel B. Effect of Belinostat on TAZ stabilization. SW480 cells were exposed to cycloheximide (CXH) at 10 µM concentration in the absence or the presence of Belinostat
Miguel Reyes-Múgica (5654968) +2 more
core +1 more source
, 2013 A: Correlation of belinostat glucuronide formation with UGT1A1 expression in human liver microsomes; B: Belinostat glucuronide formation by human liver microsomes according to wild-type, heterozygous and homozygous UGT1A1*28 genotypes.
Win-Lwin Thuya (277890) +16 more
core +1 more source
Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation
MedComm – Oncology, Volume 5, Issue 2, June 2026.The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong +4 more
wiley +1 more source