Results 51 to 60 of about 4,340 (195)
, 2011 Das Pankreaskarzinom hat auf Grund seiner hohen Mortalitätsrate und trotz verbesserter Diagnose- und Therapiemöglichkeiten nach wie vor eine schlechte Prognose.
Arnold, Stefanie
core +1 more source
Human Absorption, Metabolism, and Excretion (hAME) Mass Balance Studies in Patients With Cancer
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT Radiolabeled mass balance human studies are a critical component of clinical pharmacology programs supporting the development of new investigational drugs. These studies provide information about absorption, metabolism, and excretion (AME) of the parent drug and metabolite(s) in the human body and are normally conducted in healthy volunteers ...
Begoña de las Heras +9 more
wiley +1 more source
Frontiers in Immunology, 2023 Breast cancer is one of the common malignancies with poor prognosis worldwide. The treatment of breast cancer patients includes surgery, radiation, hormone therapy, chemotherapy, targeted drug therapy and immunotherapy. In recent years, immunotherapy has
Bi Lian, Xiaosong Chen, Kunwei Shen
doaj +1 more source
Neuroendocrine tumours through an epigenetic lens: Emerging insights for diagnosis and treatment
Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.Abstract Neuroendocrine tumours (NETs) are well‐differentiated epithelial neuroendocrine neoplasms that frequently develop in the small intestine, pancreas, and lungs. NETs originate from neuroendocrine cells specialized in hormone secretion implicated in a number of physiological processes.
Victoria Jacquot +4 more
wiley +1 more source
Design, Synthesis and Evaluation of Belinostat Analogs as Histone Deacetylase Inhibitors
Future Medicinal Chemistry, 2019 Aim: Histone deacetylase (HDAC) is an attractive target for antitumor therapy. Therefore, the development of novel HDAC inhibitors is warranted. Materials & methods: A series of HDAC inhibitors based on N-hydroxycinnamamide fragment was designed as the clinically used belinostat analog using amide as the connecting unit.
Jie-Huan Zhang +6 more
openaire +3 more sources
CrystalsThis work reports the crystallographic study of two benzenesulfonamides, 1 ((E)-N-benzyl-3-((benzylimino)methyl)-4-hydroxybenzenesulfonamide) and 2 (N-benzyl-3-(3-(N-benzylsulfamoyl)-2-oxo-2H-chromene-6-sulfonamide).
José Luis Madrigal-Angulo +6 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 19, 22 May 2026.This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti +27 more
wiley +1 more source
Belinostat Therapy for Peripheral T-Cell Lymphoma
International Journal of Health Technology and Innovation, 2022 Peripheral T-cell lymphoma (PTCL) is a type of aggressive heterogeneous non Hodgkin type of lymphoma with poor historical outcomes. The responses to conventional chemotherapy remain poor, and many rebound types of cancer growth are seen after initial therapy.
openaire +1 more source
Romidepsin and Belinostat Synergize the Antineoplastic Effect of Bortezomib in Mantle Cell Lymphoma [PDF]
Clinical Cancer Research, 2010 Abstract Purpose: Romidepsin and belinostat are inhibitors of histone deacetylases (HDACI). HDACIs are known to induce cell death in malignant cells through multiple mechanisms, including upregulation of death receptors and induction of cell cycle arrest. They are also known to be prodifferentiating.
Luca, Paoluzzi +5 more
openaire +2 more sources
TomographyCurrent diagnostic and therapeutic approaches for gliomas have limitations hindering survival outcomes. We propose spectroscopic magnetic resonance imaging as an adjunct to standard MRI to bridge these gaps.
Abinand C. Rejimon +9 more
doaj +1 more source