Results 61 to 70 of about 4,340 (195)

Dual Role of LBH589 in Triple‐Negative Breast Cancer: Inhibition of Tumor Growth and Enhancement of Antitumor Immunity

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Epigenetic dysregulation, particularly aberrant histone deacetylase (HDAC) activity, plays a critical role in the progression of breast cancer. Although HDAC inhibitors (HDACi) have demonstrated antitumor potential in preclinical studies, none have been approved for breast cancer due to inconsistent efficacy across different ...
Liang Anjing, Yuan Rong, Xiang Su, Cheng Liang, Hou Jue, Chen Zhu   +5 more
wiley   +1 more source

Differential effects of PXD101 (belinostat) on androgen-dependent and androgen-independent prostate cancer models

, 2012
Histone deacetylase inhibitors (HDACi) are promising epigenetic cancer chemotherapeutics rapidly approaching clinical use. In this study, we tested using in vitro and in vivo models the differential biological effects of a novel HDAC inhibitor ...
Dolo, V, E. Ricevuto, Carosa, E, JANNINI, EMMANUELE ANGELO FRANCESCO, S. Di Sante, Festuccia, C., Gravina, G, TOMBOLINI, Vincenzo, V. Dolo, F. Marampon, E. A. Jannini, E. Carosa, Marampon, F, Tombolini, V, Ricevuto, E, I. Giusti, C. Festuccia, Di Sante, S, G. L. Gravina, Giusti, I   +19 more
core   +1 more source

Selective Inhibition of HDAC Class I Sensitizes Leukemia and Neuroblastoma Cells to Anticancer Drugs

Biomedicines, 2021
The acquired resistance of neuroblastoma (NB) and leukemia cells to anticancer therapy remains the major challenge in the treatment of patients with these diseases.
Elmira Vagapova, Maxim Kozlov, Timofey Lebedev, Karina Ivanenko, Olga Leonova, Vladimir Popenko, Pavel Spirin, Sergey Kochetkov, Vladimir Prassolov   +8 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, Volume 20, Issue 4, Page 1008-1021, April 2026.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma

, 2017
© 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. There have been advances in personalized therapy directed by molecular profiles in lung adenocarcinoma, but not in lung squamous cell carcinoma (SCC).
Chng, W., Kong, L.R, Eichhorn, P.J.A, Lee, S.C, Lee, S., Chng, W.J, Weijie R. Ong, Goh, B., Kong, L., Ong, W.R, Li R. Kong, Wee J. Chng, Bi, C, Bi, C., Eichhorn, Pieter, Pieter J. A. Eichhorn, Huynh, H, Chonglei Bi, Boon C. Goh, Ong, W., Hung Huynh, Soo C. Lee, Tuan Z. Tan, Goh, B.C, Tan, T., Tan, T.Z, Huynh, H.   +26 more
core   +1 more source

Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells

Molecular Cancer, 2008
Background Histone acetylation is an epigenetic modification involved in the regulation of gene expression, balanced by histone acetyl transferases and histone deacetylase (HDAC) enzymes.
Dejligbjerg Marielle, Grauslund Morten, Litman Thomas, Collins Laura, Qian Xiaozhong, Jeffers Michael, Lichenstein Henri, Jensen Peter, Sehested Maxwell   +8 more
doaj   +1 more source

Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus

Arthritis &Rheumatology, Volume 78, Issue 4, Page 880-895, April 2026.
Objective Systemic lupus erythematosus (SLE) is characterized by increased Type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Combining Small‐Molecular Compounds With CAR T‐Cell Therapy: Novel Strategies for Enhanced Cancer Immunotherapy

Cancer Innovation, Volume 5, Issue 2, April 2026.
Chimeric antigen receptor (CAR) T‐cell therapy, although revolutionary for haematological malignancies, faces significant challenges, including T‐cell exhaustion, limited persistence, and treatment‐related toxicity. The integration of small‐molecule compounds offers a promising strategy to overcome these limitations.
Rangzi Yi, Zijian Zhang, Yang Yang, Haichuan Zhu   +3 more
wiley   +1 more source

Belinostat in patients with refractory or relapsed peripheral T-cell lymphoma: a perspective review [PDF]

Therapeutic Advances in Hematology, 2015
Peripheral T-cell lymphoma (PTCL) is a disease with poor prognosis and limited treatment options. Recent advances in cancer biology suggest that PTCL may be characterized by gross epigenetic dysregulation, which may help explain its sensitivity to histone deacetylase (HDAC) inhibitors.
Ahmed, Sawas, Dejan, Radeski, Owen A, O'Connor   +2 more
openaire   +2 more sources

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Malaria, schistosomiasis and leishmaniases are among the most prevalent tropical parasitic diseases and each requires new innovative treatments. Targeting essential parasite pathways, such as those that regulate gene expression and cell cycle progression,
Ming Jang Chua, Megan S.J. Arnold, Weijun Xu, Julien Lancelot, Suzanne Lamotte, Gerald F. Späth, Eric Prina, Raymond J. Pierce, David P. Fairlie, Tina S. Skinner-Adams, Katherine T. Andrews   +10 more
doaj   +1 more source