Results 31 to 40 of about 4,340 (195)
The nature of the GRE influences the screening for GR-activity enhancing modulators. [PDF]
PLoS ONE, 2017 Glucocorticoid resistance (GCR), i.e. unresponsiveness to the beneficial anti-inflammatory activities of the glucocorticoid receptor (GR), poses a serious problem in the treatment of inflammatory diseases.
Karen Dendoncker +5 more
doaj +1 more source
Thermodynamic and transport properties of Belinostat
BibechanaHDACs inhibitors, Belinostat inhibits class I HDACs, class II HDACs and class IV HDAC proteins activities. Antitumor activity of Belinostat is attributed to epi- genetic control of gene expression and inhibition of protein repression.
Narayan Gautam +4 more
doaj +3 more sources
Linfoma angioinmunoblástico de células T [PDF]
Galicia Clínica, 2016 Se trata de un linfoma muy agresivo, con una mediana de supervivencia en torno a los 3 años. En cuanto al tratamiento, se han ensayado varias modalidades terapéuticas entre las cuales se encuentran los corticoides, los fármacos citotóxicos (vorinostat ...
Gargantilla P, Martin BM, Pintor E
doaj +1 more source
Translational Oncology, 2021 Cancer cell phenotypes evolve during a tumor's treatment. In some cases, tumor cells acquire cancer stem cell-like (CSL) traits such as resistance to chemotherapy and diminished differentiation; therefore, targeting these cells may be therapeutically ...
Feng Chi +10 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Pralatrexate (Folotyn; PLX) and belinostat (Beleodaq; BLS) are registered for the treatment of patients with peripheral T-cell lymphoma (PTCL) and are being considered for other lymphomas.
Godefridus J. Peters +6 more
doaj +1 more source
, 2023 Herein we describe the design and synthesis of Contilisant+Belinostat hybrids as polyfunctionalized indole derivatives for the treatment of a broad diversity of cancers and neurodegenerative diseases, such as glioblastoma, and Alzheimer’s disease (AD ...
Ander, Matheu +9 more
core +1 more source
Apoptotic effect of Belinostat
, 2021 Aim: Breast cancer continues to be the most common type of cancer among women. Recent development in epigenomics has highlighted key mechanisms in which epigenetic regulation contributes to cancer treatment.
Eroglu Gunes, Canan +3 more
core
Tạp chí Khoa học Đại học Cần Thơ, 2020 Belinostat là thuốc có khả năng ức chế enzyme HDAC khá tốt, được sử dụng điều trị các khối u ác tính về huyết học và khối u rắn. Trong nghiên cứu này, các dẫn xuất tương tự belinostat đã được tổng hợp thành công qua quy trình đơn giản và hiệu quả, phù ...
Nguyễn Cường Quốc +12 more
doaj +1 more source
, 2013 Belinostat metabolism pathway in human plasma with glucuronidation of belinostat as the dominant metabolism.
Win-Lwin Thuya (277890) +16 more
core +1 more source
Update on histone deacetylase inhibitors in peripheral T-cell lymphoma (PTCL)
Clinical Epigenetics, 2023 Peripheral T-cell lymphomas (PTCLs) are a group of highly aggressive malignancies with generally poor prognoses, and the first-line chemotherapy of PTCL has limited efficacy.
Guang Lu +7 more
doaj +1 more source