Results 31 to 40 of about 16,181 (141)

Catch and release’ cascades: a resin-mediated three-component cascade approach to small molecules [PDF]

, 2006
The application of a ‘catch and release’ approach to palladium-catalysed multi-component cascade reactions leads to diverse libraries of pharmacologically interesting small molecules in high yield and with excellent ...
Andrew Cook, Bannwarth, Baxter, Brain, Brown, De Luca, Dondas, Gai, Graybill, Grigg, Hoekstra, Kumpathy, Laganis, Larsen, Lee, Ley, Mason, Porcheddu, Ronald Grigg, Sui, Sumiyoshi, Thompson, Thompson, Wu   +23 more
core   +1 more source

A structural systematic study of four isomers of difluoro-N-(3-pyridyl)benzamide [PDF]

, 2009
The four isomers 2,4-, (I), 2,5-, (II), 3,4-, (III), and 3,5-difluoro-N-(3-pyridyl)benzamide, (IV), all with formula C12H8F2N2O, display molecular similarity, with interplanar angles between the C6/C5N rings ranging from 2.94 (11)° in (IV) to 4.48 (18 ...
Anderson, Frankie P., Gallagher, John F., Lough, Alan J., McMahon, Joyce   +3 more
core   +1 more source

Study of the reactivity of aminocyanopyrazoles and evaluation of the mitochondrial reductive function of some products

Heterocyclic Communications, 2022
This research investigated the general high-throughput synthetic protocol for the accelerated synthesis of functionalized trifluoromethylpyrazolopyrimidines 3 and N-(5-cyano-3-methyl-1-phenyl-1H-pyrazol-4-yl) benzamide 4 from aminocyanopyrazole 1 ...
Bellili Soumaya, Coltman Nicholas J., Hodges Nikolas J., Allouche Fatma   +3 more
doaj   +1 more source

Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis [PDF]

, 2013
PMCID ...
A Compston, A Shetty, A Zimmer, AC Howlett, AE Bygrave, C Bolton, C Delarasse, C Delarasse, C Teuscher, Carolyn Tanner, CS Wu, CS Wu, D Baker, D Baker, D Baker, D Baker, D Baker, D Baker, D Baker, D McHugh, David Baker, David L. Selwood, DL Smith-Bouvier, E de Lago, E Kozela, E Montero, E Zurita, F Docagne, F Wu, G Disanto, G Musumeci, G Paltser, G Pryce, G Pryce, G Wotherspoon, Gareth Pryce, Gavin Giovannoni, Gregory J. Michael, H Kataoka, HM Vesterinen, I Mendel, J Corey-Bloom, J Karlsson, J Palazuelos, JA Encinas, JB Davis, JH Slingsby, JK O'Neill, JL Croxford, JL Croxford, JM Coquet, JP Zajicek, K Li, K Maresz, KM Spach, L Cristino, LM Olsson, LS Whyte, M Sundvall, M Webb, MF Festing, NA Balenga, NE Buckley, O Ofek, PC Staton, PD Fillmore, PM Hoi, RA Ross, RA Ross, RC Axtell, RG Pertwee, RG Pertwee, RJ Butterfield, Roberto Furlan, RS Graves, Ruth A. Ross, S Al-Izki, S Al-Izki, S Amor, S Amor, S Amor, S Katona, S Levine, S Levine, S Rossi, S Saadoun, Samuel J. Jackson, SC Landis, SJ Allen, Sofia Sisay, V Devonshire, Y Okuda, ZY Lou   +92 more
core   +3 more sources

Photoisomerization of Azobenzene‐Extended Charybdotoxin for the Optical Control of Kv1.2 Potassium Channel Activity

Angewandte Chemie, Volume 137, Issue 19, May 5, 2025.
Click‐chemistry compatible azobenzenes are synthesized and coupled on various positions at the surface of a disulfide‐bridged natural peptide. Monomers and dimers are produced and linked by azobenzene. The impact of azobenzene photoswitching on the ion channel blocking potency of the peptide is evaluated and revealed that proper positioning leads to ...
Yanis Achouba, Basile Peres, Steven Ascoët, Hervé Meudal, Cécile Caumes, Claude Zoukimian, Hugo Millet, Maureen Choteau‐Bodor, Cathy Carvalhosa, Mikael Croyal, Fella Bouchama, Heike Wulff, Stéphane Téletchéa, Rémy Béroud, Eléna Ishow, Céline Landon, Ahcène Boumendjel, Jérôme Montnach, Michel De Waard   +18 more
wiley   +2 more sources

Crystal structure of 3-chloro-N-(2-nitrophenyl)benzamide

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C13H9ClN2O3, the mean plane of the central amide fragment (r.m.s. deviation = 0.016 Å) subtends dihedral angles of 15.2 (2) and 8.2 (2)° with the chloro- and nitro-substituted benzene rings, respectively.
Rodolfo Moreno-Fuquen, Alexis Azcárate, Alan R. Kennedy   +2 more
doaj   +1 more source

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]

, 2010
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A., Jamieson, Craig, Maclean, John K. F., Morrow, John A., Rankovic, Zoran   +4 more
core   +1 more source

Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors

Metabolites, 2018
A series of benzamides incorporating 4-sulfamoyl moieties were obtained by reacting 4-sulfamoyl benzoic acid with primary and secondary amines and amino acids. These sulfonamides were investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA,
Morteza Abdoli, Murat Bozdag, Andrea Angeli, Claudiu T. Supuran   +3 more
doaj   +1 more source

Different intra- and inter-molecular hydrogen-bonding patterns in (3S,4aS,8aS)-2-[(2R,3S)-3-(2,5-X2-benzamido)-2-(2,5-X2-benzo-yloxy)-4-phenyl-butyl]-N-tert-butyldeca-hydro-iso-quinoline-3-carboxamides (X = H or Cl) : compounds with moderate aspartyl protease inhibition activity [PDF]

, 2017
We thank the EPSRC National Crystallography Service (University of Southampton) for the X-ray data collections.Peer reviewedPublisher ...
Cunico, Wilson, Ferreira, Maria de Lourdes G, Harrison, William T A, Wardell, James L.   +3 more
core   +2 more sources

Exploring the cocrystallization potential of urea and benzamide [PDF]

, 2018
The cocrystallization landscape of benzamide and urea interacting with aliphatic and aromatic carboxylic acids was studied both experimentally and theoretically. Ten new cocrystals of benzamide were synthesized using an oriented samples approach via a fast dropped evaporation technique. Information about types of known bi-component cocrystals augmented
arxiv   +1 more source