Results 31 to 40 of about 13,855 (240)

5-(4H)-Oxazolones and Their Benzamides as Potential Bioactive Small Molecules

Molecules, 2020
The five membered heterocyclic oxazole group plays an important role in drug discovery. Oxazolones present a wide range of biological activities. In this article the synthesis of 4-substituted-2-phenyloxazol-5(4H)-ones from the appropriate substituted ...
Evangelos Mavridis, Eleftherios Bermperoglou, Eleni Pontiki, Dimitra Hadjipavlou-Litina   +3 more
doaj   +1 more source

2-(Methylsulfinyl)benzamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the crystal of the title compound, C(8)H(9)NO(2)S, synthesized by the oxidation of 2-(methyl-sulfan-yl)benzamide using NaOCl with 2,2,6,6-tetra-methyl-piperidyl-1-oxy (TEMPO) as the catalyst, mol-ecules are linked via inter-molecular N-H⋯O(amide) hydrogen bonds, forming centrosymmetric amide-amide dimers which are extended into a two-dimensional ...
openaire   +4 more sources

Direct alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions

Communications Chemistry, 2021
Direct conversion of amides to ketones typically requires the use of transition metal catalysts or reactive organometallic reagents. Here the direct alkylation of benzamides with methyl sulfides using LDA as base provides access to thioalkoxyketones.
Can-Can Bao, Hui-Zhen Du, Yan-Long Luo, Bing-Tao Guan   +3 more
doaj   +1 more source

Synthesis and crystal structures of rhodium acetate paddle‐wheel complexes with anchor group‐functionalised and hydrogen bond‐supported axial ligands

Zeitschrift für anorganische und allgemeine Chemie, Volume 648, Issue 23, December 13, 2022., 2022
Abstract We report the synthesis and X‐ray structures of four Rh2(OAc)4(LAx)2 (OAc=acetate, CH3COO−) paddle‐wheel complexes (C1−C4) with methylthio‐modified axial ligands LAx derived from benzamidine (L1), anilinopyrimidine (L2) or isothiourea (L3, L4) that are capable of forming N−H⋅⋅⋅O hydrogen bonds to the equatorially bridging acetate ligands. This
André Mang, Michael Linseis, Rainer F. Winter   +2 more
wiley   +1 more source

Photoisomerization of Azobenzene‐Extended Charybdotoxin for the Optical Control of Kv1.2 Potassium Channel Activity

Angewandte Chemie, EarlyView.
Click‐chemistry compatible azobenzenes are synthesized and coupled on various positions at the surface of a disulfide‐bridged natural peptide. Monomers and dimers are produced and linked by azobenzene. The impact of azobenzene photoswitching on the ion channel blocking potency of the peptide is evaluated and revealed that proper positioning leads to ...
Yanis Achouba, Basile Peres, Steven Ascoët, Hervé Meudal, Cécile Caumes, Claude Zoukimian, Hugo Millet, Maureen Choteau‐Bodor, Cathy Carvalhosa, Mikael Croyal, Fella Bouchama, Heike Wulff, Stéphane Téletchéa, Rémy Béroud, Eléna Ishow, Céline Landon, Ahcène Boumendjel, Jérôme Montnach, Michel De Waard   +18 more
wiley   +2 more sources

Experimental pharmacological research regarding some newly synthesized benzamides on central nervous system functions

Journal of Mind and Medical Sciences, 2017
Three newly synthesized benzamides by the Department of Pharmaceutical Chemistry of the Faculty of pharmacy from the University of Medicine and Pharmacy „Carol Davila” Bucharest were tested in order to determine whether these new molecules have similar ...
Cornel Chiriță, Emil Ștefănescu, Cristina D. Marineci, Simona Negreș, Diana C. Nuță   +4 more
doaj   +1 more source

LIBX‐A401: A Novel Selective Inhibitor of Acyl‐CoA Synthetase Long Chain Family Member 4 (ACSL4) and Its Binding Mode

Angewandte Chemie, EarlyView.
The discovery of LIBX‐A401, a potent and selective ACSL4 inhibitor derived from rosiglitazone is reported. HDX‐MS reveals that LIBX‐A401 stabilizes the ACSL4 C‐terminus and alters the fatty acid (FA) gate domain. Consistently, photoaffinity labeling, molecular dynamics, and mutagenesis identify key binding residues within the FA pocket.
Darius Mazhari Dorooee, Séverine Ravez, Didier Vertommen, Nicolas Renault, Nicolas Papadopoulos, Romain Marteau, Emeline Charnelle, Karine Porte, Alexandre Gobert, Nathalie Hennuyer, Gaetan Herinckx, Maëla Pautric, Aurélie Jonneaux, Jean Christophe Devedjian, David Devos, Bart Staels, Patricia Melnyk, Stefan N. Constantinescu, Raphaël Frédérick, Jamal El Bakali   +19 more
wiley   +2 more sources

4-Iodo-N-(phenylsulfonyl)benzamide hemihydrate

IUCrData, 2017
In the title hemihydrate, 2C13H10INO3S·H2O, there are two organic molecules (A and B) and one water molecule in the asymmetric unit. The benzene rings are inclined to one another by 77.98 (1)° in A and 79.81 (9)° in B. The A and B molecules are connected
P. A. Suchetan, A. G. Sudha, E. Suresha, N. K. Lokanath, S. Naveen, Ismail Warad   +5 more
doaj   +1 more source

N-(2,6-Dichlorophenyl)benzamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2008
The conformation of the N-H and C=O bonds in the structure of the title compound (N26DCPBA), C(13)H(9)Cl(2)NO, are anti to each other, similar to that observed in N-phenyl-benzamide (NPBA), N-(2-chloro-phen-yl)benzamide (N2CPBA), N-(2,3-dichloro-phen-yl)benzamide (N23DCPBA) and other benzanilides. The asymmetric unit of N26DCPBA contains two mol-ecules.
Hartmut Fuess, Miroslav Tokarčík, B.P. Sowmya, B.T. Gowda, Jozef Kožíšek   +4 more
openaire   +4 more sources

Benzamide‐Directed Hydroarylative Cross‐Couplings Using Minimally Activated Alkenes: Enantioselective Synthesis of Tertiary and Quaternary Stereocenters

Angewandte Chemie, EarlyView.
Benzamide‐directed iridium‐catalyzed branched selective and enantioselective C(sp2)‐H additions to minimally activated alkenes give tertiary and quaternary benzylic stereocenters under byproduct‐free conditions. The processes are enabled by a family of SPINOL‐based homochiral diphosphonite ligands.
Timothy P. Aldhous, Raymond Chung, Abbas Hassan, Andrew G. Dalling, Phillippa Cooper, Simon Grélaud, Richard J. Mudd, Lyman J. Feron, Paul D. Kemmitt, John F. Bower   +9 more
wiley   +2 more sources