Results 61 to 70 of about 24,787 (257)

2-Hydroxy-N-phenylbenzamides and Their Esters Inhibit Acetylcholinesterase and Butyrylcholinesterase

Biomolecules, 2019
The development of novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) represents a viable approach to alleviate Alzheimer’s disease.
Martin Krátký, Šárka Štěpánková, Neto-Honorius Houngbedji, Rudolf Vosátka, Katarína Vorčáková, Jarmila Vinšová   +5 more
doaj   +1 more source

An Electrochemical Way to Generate Amphiphiles from Hydrazones for the Synthesis of 1,2,4‐Triazole Scaffold Cyclic Compounds

ChemistryOpen, 2022
An electro‐oxidative cyclization pathway in which hydrazones are selected as starting materials to generate amphiphiles by reacting with benzylamines and benzamides was reported.
Wangyu Li, Mingteng Xiong, Xiao Liang, Dungai Wang, Heping Zhu, Prof. Dr. Yuanjiang Pan   +5 more
doaj   +1 more source

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]

, 2010
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A., Jamieson, Craig, Maclean, John K. F., Morrow, John A., Rankovic, Zoran   +4 more
core   +1 more source

Microwave assisted green synthesis of aryl methoxylated benzamides and 2-oxazolines from biomass

Green Processing and Synthesis, 2013
This paper presents a simple, rapid and efficient green synthesis of aryl methoxylated benzamides and 2-oxazolines from renewable Eucalyptus biomass – tar derivatives.
Okuma Adriana Akemi, Antônio Daphne Chiara, Carazza Fernando, Duarte Lucienir Pains   +3 more
doaj   +1 more source

Benzamide Trimethoprim Derivatives as Human Dihydrofolate Reductase Inhibitors—Molecular Modeling and In Vitro Activity Study

Biomedicines
Human dihydrofolate reductase (hDHFR) is an essential cellular enzyme, and inhibiting its activity is a promising strategy for cancer therapy. We have chosen the trimethoprim molecule (TMP) as a model compound in our search for a new class of hDHFR ...
Danuta Drozdowska, Agnieszka Wróbel-Tałałaj, Cezary Parzych, Artur Ratkiewicz   +3 more
doaj   +1 more source

Synthesis of Phthalimides: A New Entry via TBAI-Catalyzed Intramolecular Cyclization of 2-(Hydroxymethyl)benzamides

SynOpen, 2018
Herein we report an unprecedented metal-free TBAI/TBHP mediated C–N bond formation via intramolecular cyclization of 2-(hydroxymethyl)benzamides to furnish N-substituted phthalimides in excellent yields.
Kare Nagaraju, Nomula Rajesh, Palakodety Radha Krishna   +2 more
doaj   +1 more source

Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists [PDF]

, 2010
PURPOSE: The ferret cisplatin emesis model has been used for ~30 years and enabled identification of clinically used anti-emetics. We provide an objective assessment of this model including efficacy of 5-HT(3) receptor antagonists to assess its ...
A Fink-Jensen, A Lehmann, A Ozaki, AG King, AH Lau, AL Harris, AM Holmes, AP Florczyk, AP Florczyk, B Costall, B Costall, B Costall, B Costall, B Costall, B Costall, B Lasheras, C Bountra, C. C. Apfel, CJ Gardner, CJ Gardner, CJ Gardner, CL Gooch, D Moher, D Spina, D Tattersall, D Tattersall, DG Altman, DJ Reynolds, DR Gandara, E Blum, E Chevalier, F Roila, FD Tattersall, FD Tattersall, FD Tattersall, GA Higgins, GJ Hollingworth, H Nakayama, H Yamakuni, H Yamakuni, HE Marr, HE Marr, HE Marr, HL Borison, I Angel, I Monkovic, IT Jantunen, J Bermudez, J Hawthorn, J Horn, J Horn, J. A. Rudd, JA Gylys, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JE Schurig, JH Kim, JJ Hale, JJ Hale, JM Barnes, JN Matthews, JW Watson, K Haga, K Haga, L Singh, LE McCarthy, LR Fitzpatrick, LX Cubeddu, M Martin, M Marty, M Minami, M Minami, M Minami, M Ohta, M Tsuchiya, MD Sickle Van, MG Kris, MG Kris, MR Macleod, MR Macleod, MR Macleod, MT Price, N Fukunaka, N Percie du Sert, N Yoshida, N Yoshida, N Yoshida, N Yoshida, N. Percie du Sert, NM Barnes, NM Barnes, NM Rupniak, P Bhandari, P Delagrange, P Pound, P Preziosi, P Ruff, P. L. R. Andrews, PJ Hesketh, PJ Hesketh, PLR Andrews, PLR Andrews, PR Blower, R DerSimonian, R Hargreaves, R Stables, RA Matthews, RC Miller, RD Clark, RD Youssefyeh, RD Youssefyeh, RM Eglen, RM Eglen, RM Eglen, RM Navari, S Bingham, S Gonsalves, S Taniguchi, T Endo, T Endo, T Endo, T Endo, T Endo, T Ito, T Kamato, T Kamato, T Matsui, T Yoshikawa, T Yoshikawa, T Yoshikawa, TM Dando, TS Sam, TS Sam, TS Sam, V Bebarta, WD Miner, WD Miner, WD Miner, Y Kubota, Y Shiroshita, Y Shiroshita, Y Watanabe, YL Liu   +153 more
core   +2 more sources

A Michaelis‐Arbuzov‐Type Pathway to a Protected 2ʹ‐Deoxy‐2ʹ‐Selenomethyl‐Adenosine‐3ʹ,5ʹ‐Phosphoroselenolate Guanosine Dinucleotide for Use in Modified m7G Cap Synthesis

Chemistry – A European Journal, EarlyView.
Here we report a synthesis of the dinucleotide 4 for a projected future total synthesis of the m7G cap 1. Highlights of the route include: 1) a 3ʹ‐H‐phosphonate/5ʹ‐selenocyanate Michaelis‐Arbuzov coupling to forge the 3ʹ,5ʹ‐phosphoroselenolate; 2) an Amosova reductive selenomethylation to install the 2ʹ‐SeMe; 3) a solid CPR II 5ʹ‐O‐phosphitylation; and
K. Lawrence E. Hale, Helen O. McCarthy, Mark G. McLaughlin   +2 more
wiley   +1 more source

Synthesis of Functionalized 9-Substituted Fluorene Derivatives via Boron Trifluoride Catalysed Reaction of Coplanar 9-(Phenylethynyl)-9H-fluoren-9-ols, Aryl Aminoamides and N-Bromosuccinimide

SynOpen, 2021
A boron trifluoride catalysed reaction of coplanar 9-(phenyl­ethynyl)-9H-fluoren-9-ols with various 2-aminobenzamides affords a number of highly functionalized, conjugated (Z)-2-((2-(9H-fluoren-9-ylidene)-1-phenylethylidene)amino) benzamides in excellent
Mohanakumaran Athira, Ponnusamy Shanmugam   +1 more
doaj   +1 more source

Benzamide–picric acid (1/1) [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C(7)H(7)NO·C(6)H(3)N(3)O(7), one of the nitro groups of the picric acid mol-ecule lies in the plane of the attached benzene ring [dihedral angle = 1.4 (1)°] while the other two are twisted away by 9.9 (1) and 30.3 (1)°. In the benzamide mol-ecule, the amide group is almost coplanar with the benzene ring [dihedral angle = 4.4 (1)°]
Sivaramkumar, M. S., Velmurugan, R., Sekar, M., Ramesh, P., Ponnuswamy, M. N.   +4 more
openaire   +2 more sources