Results 31 to 40 of about 6,457 (248)
Diversity-oriented synthesis of 1,3-benzodiazepines [PDF]
, 2017 © 2017 Elsevier Ltd A concise assembly of the 1,3-benzodiazepine core from A 3 -coupling-derived propargylamines and ortho-bromophenylisocyanates is described.
Li, Binbin +7 more
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Pharmaceutically relevant (hetero)cyclic compounds and natural products from lignin-derived monomers:Present and perspectives [PDF]
, 2021 Lignin, the richest source of renewable aromatics on the planet, is an intriguing raw material for the construction of value-added aromatics. In the past decade, much progress has been made regarding the development of efficient lignin depolymerization ...
Afanasenko, Anastasiia, Barta, Katalin
core +1 more source
SPION nanoparticles for delivery of dopaminergic isoquinoline and benzazepine derivatives
Bioorganic & Medicinal Chemistry, 2022 Superparamagnetic iron nanoparticles (SPIONs) have become one of the most useful colloidal systems in nanomedicine. We report here the preparation of new hybrid core@shell systems based on SPION nanoparticles coated with a SiO2 shell (SPION@SiO2) and functionalized with carboxyl groups (SPION@SiO2-COOH).
Lucena-Serrano, Cristina +9 more
openaire +5 more sources
Fe‐Catalyzed α‐C(sp3)−H Amination of N‐Heterocycles
Angewandte Chemie, Volume 137, Issue 5, January 27, 2025.An iron(II)‐catalyzed α‐selective C−H amination of N‐heterocycles is reported. It employs the N‐heterocycle as the limiting reagent and presumably involves the formation of a reactive Fe‐nitrene/imidyl radical species. This operationally simple method is amenable to the late‐stage functionalization of natural products and APIs.
Andrea Geraci, Olivier Baudoin
wiley +2 more sources
Graph-Sparse LDA: A Topic Model with Structured Sparsity [PDF]
, 2014 Originally designed to model text, topic modeling has become a powerful tool for uncovering latent structure in domains including medicine, finance, and vision.
Adams, Ryan +2 more
core +1 more source
Impact of spermiogram and sperm function test in idiopathic recurrent pregnancy loss [PDF]
, 2015 Aims: To evaluate the role of sperm factors in idiopathic recurrent pregnancy loss cases. Methods: We recruited 100 male subjects where their female partners experienced 2 or more idiopathic pregnancy losses.
Chaithra, T. P +3 more
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New Catalytic Routes to Benzofused Seven-Membered Azaheterocycles [PDF]
, 2021 Benzazepines, benzodiazepines and benzoxazepines compose a privileged family of natural products and pharmaceuticals. Their remarkable biological activity made them useful drugs to treat a large variety of issues.
Velasco Rubio, Álvaro
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Angewandte Chemie, Volume 136, Issue 12, March 18, 2024.Asymmetric deprotonation of N‐benzyl urea derivatives of nitrogen heterocycles leads to enantioselective insertion of the benzylic substituent into an aromatic C−N bond. Treatment of the ring‐expanded products induces a stereospecific ring‐contraction that results in an overall asymmetric enantioselective one‐carbon enlargement of the heterocycle ...
Rajendra K. Mallick +2 more
wiley +2 more sources
Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists. [PDF]
, 2015 A series of pyrido[3,4-d]azepines that are potent and selective 5-HT2C receptor agonists is disclosed. Compound 7 (PF-04781340) is identified as a suitable lead owing to good 5-HT2C potency, selectivity over 5-HT2B agonism, and in vitro ADME properties ...
Allwood, Daniel M +11 more
core +4 more sources
Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors [PDF]
, 2016 The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist.
Contreras-Cáceres, Rafael +5 more
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