Results 31 to 40 of about 4,384 (210)

Recent Advances in Transition-Metal Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines [PDF]

, 2020
NOTICE: This is the peer reviewed version of the following article: Velasco-Rubio, A., Varela J. A., Saá C. (2020). Recent Advances in Transition-Metal Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines. Adv. Synth. Catal., 362, 22, 4861-
Bremner J. B., Carlos Saá, Clayton T., Elgarf A. A., Griffin C. E., Jesús A. Varela, Mantaj J., Meyer A. G., Meyer A. G., Meyer A. G., Pareek A., Ram V. J., Yin P., Álvaro Velasco‐Rubio   +13 more
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Diversity-oriented synthesis of 1,3-benzodiazepines [PDF]

, 2017
© 2017 Elsevier Ltd A concise assembly of the 1,3-benzodiazepine core from A 3 -coupling-derived propargylamines and ortho-bromophenylisocyanates is described.
Li, Binbin, Liu, Chao, Pereshivko, Olga P, Peshkov, Vsevolod A, Van der Eycken, Erik V, Van Hecke, Kristof, Wang, Gaigai, Wang, Yingchun   +7 more
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Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory. [PDF]

, 2016
RATIONALE: Antenatal exposure to the glucocorticoid dexamethasone dramatically increases the number of mesencephalic dopaminergic neurons in rat offspring.
Dalley, J.W., Dalley, J.W., Gillies, G.E., Gillies, G.E., Hensman, D., Hensman, D., Jupp, B., Jupp, B., Kentrop, J., Kentrop, J., McArthur, S., McArthur, S., Robbins, T.W., Robbins, T.W., Venus, B., Venus, B., Virdee, K., Virdee, K., Wilkinson, J., Wilkinson, J.   +19 more
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Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists. [PDF]

, 2015
A series of pyrido[3,4-d]azepines that are potent and selective 5-HT2C receptor agonists is disclosed. Compound 7 (PF-04781340) is identified as a suitable lead owing to good 5-HT2C potency, selectivity over 5-HT2B agonism, and in vitro ADME properties ...
Allwood, Daniel M, Battilocchio, Claudio, Blakemore, David C, Fish, Paul V, Jenkinson, Stephen, Jessiman, Alan S, Ley, Steven V, McMurray, Gordon, Moore, Dianna E, Rouquet, Guy, Spain, Malcolm, Storer, R Ian   +11 more
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Identifying translational science within the triangle of biomedicine [PDF]

, 2013
Background: The National Institutes of Health (NIH) Roadmap places special emphasis on “bench-to-bedside” research, or the “translation” of basic science research into practical clinical applications.
Weber, Griffin M
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Arylbenzazepines Are Potent Modulators for the Delayed Rectifier K+ Channel: A Potential Mechanism for Their Neuroprotective Effects [PDF]

, 2010
(±) SKF83959, like many other arylbenzazepines, elicits powerful neuroprotection in vitro and in vivo. The neuroprotective action of the compound was found to partially depend on its D1-like dopamine receptor agonistic activity. The precise mechanism for
Bernhard, Eric J., Chen, Xue-Qin, Hu, Guo-Yuan, Jin, Guo-Zhang, Neumeyer, John Leopold, Zhang, Ao, Zhang, Jing, Zhen, Xuechu   +7 more
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Fe‐Catalyzed α‐C(sp3)−H Amination of N‐Heterocycles

Angewandte Chemie, Volume 137, Issue 5, January 27, 2025.
An iron(II)‐catalyzed α‐selective C−H amination of N‐heterocycles is reported. It employs the N‐heterocycle as the limiting reagent and presumably involves the formation of a reactive Fe‐nitrene/imidyl radical species. This operationally simple method is amenable to the late‐stage functionalization of natural products and APIs.
Andrea Geraci, Olivier Baudoin
wiley   +2 more sources

Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases. [PDF]

, 2016
Notch is a key player in various developmental processes during the embryonic stage as well as in regulating tissue homeostasis, cell differentiation, and stem cell maintenance in adult life.
Dela Golshayan, Lucienne Juillerat-Jeanneret, Massard C., Müllberg J., Okada H., Rajesh Kumar, Shawber C.   +6 more
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A hydrazine-free Wolff–Kishner reaction suitable for an undergraduate laboratory [PDF]

, 2016
A Wolff–Kishner reaction that does not require hydrazine has been developed. The reaction sequence has two steps; formation of a carbomethoxyhydrazone from methyl hydrazinocarboxylate and acetophenone, then decomposition of this intermediate by treatment
Cranwell, Philippa B., Russell, Andrew T.   +1 more
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Designing organometallic compounds for catalysis and therapy [PDF]

, 2012
Bioorganometallic chemistry is a rapidly developing area of research. In recent years organometallic compounds have provided a rich platform for the design of effective catalysts, e.g. for olefin metathesis and transfer hydrogenation.
Abraha Habtemariam, Aird, Alama, Alama, Alberto, Allardyce, Allen, Allen, Ana M. Pizarro, Anand, Ang, Ang, Anna Louisa Noffke, Arancibia, Barragan, Barry, Barry, Barry, Barry, Bergamo, Bergamo, Betanzos-Lara, Betanzos-Lara, Betanzos-Lara, Brewster, Bugarcic, Bugarcic, Canivet, Carrión, Caruso, Casini, Casini, Casini, Chaplin, Chen, Chen, del Pozo, Desmard, Dorcier, Dorcier, Dougan, Dougan, Dyson, Erxleben, Feng, Fernandez, Filak, Fu, Fu, Fujii, Giannini, Gormen, Gossens, Grau, Grguric-Sipka, Grubbs, Gröger, Guichard, Guo, Guo, Habtemariam, Hambley, Hamels, Hanif, Hanif, Harris, Hartinger, Hashiguchi, Hayes, Hayward, Herman, Hindi, Hogan, Hollmann, Hu, Hull, Ito, Jafarpour, Jennerwein, Jira, Jungwirth, Kandioller, Kisova, Kljun, Kopf, Kopf-Maier, Kopf-Maier, Kopf-Maier, Kopf-Maier, Kröger, Kuninobu, Lee, Leiva, Li, Liu, Liu, Liu, Liu, Liu, Lo, Lo, Lummen, Lutz, Maenaka, Meggers, Meggers, Meggers, Melchart, Melchart, Melchart, Melendez, Mendes, Motterlini, Mross, Novakova, Novakova, Novakova, Noyori, Noyori, Oehninger, Ogo, Ogo, Olliaro, Page, Patiño, Peacock, Peacock, Peacock, Peacock, Pelletier, Peter J. Sadler, Petzold, Petzold, Pitto-Barry, Pitto-Barry, Pizarro, Plazuk, Rocamora-Reverte, Ruiz, Ruppert, Sandoval, Sanford, Sarsam, Schatzschneider, Schmid, Schäfer, Scolaro, Selander, Skinner, Sriskandakumar, Steckhan, Strohfeldt, Suss-Fink, Sweeney, Takebayashi, Tan, Therrien, Therrien, Toney, Top, Top, Top, Trnka, Turel, van der Donk, van Rijt, van Rijt, van Rijt, Vessières, Vougioukalakis, Vougioukalakis, Wang, Wang, Wang, Ward, Williams, Williams, Wong, Wu, Wu, Yabluchanskiy, Yamakawa, Yan, Yano, Yuasa, Zava, Zekri, Zhao, Zoeller   +188 more
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