Results 31 to 40 of about 6,469 (247)

Diversity-oriented synthesis of 1,3-benzodiazepines [PDF]

open access: yes, 2017
© 2017 Elsevier Ltd A concise assembly of the 1,3-benzodiazepine core from A 3 -coupling-derived propargylamines and ortho-bromophenylisocyanates is described.
Li, Binbin   +7 more
core   +2 more sources

SPION nanoparticles for delivery of dopaminergic isoquinoline and benzazepine derivatives

open access: yesBioorganic & Medicinal Chemistry, 2022
Superparamagnetic iron nanoparticles (SPIONs) have become one of the most useful colloidal systems in nanomedicine. We report here the preparation of new hybrid core@shell systems based on SPION nanoparticles coated with a SiO2 shell (SPION@SiO2) and functionalized with carboxyl groups (SPION@SiO2-COOH).
Lucena-Serrano, Cristina   +9 more
openaire   +5 more sources

Fe‐Catalyzed α‐C(sp3)−H Amination of N‐Heterocycles

open access: yesAngewandte Chemie, Volume 137, Issue 5, January 27, 2025.
An iron(II)‐catalyzed α‐selective C−H amination of N‐heterocycles is reported. It employs the N‐heterocycle as the limiting reagent and presumably involves the formation of a reactive Fe‐nitrene/imidyl radical species. This operationally simple method is amenable to the late‐stage functionalization of natural products and APIs.
Andrea Geraci, Olivier Baudoin
wiley   +2 more sources

Identifying translational science within the triangle of biomedicine [PDF]

open access: yes, 2013
Background: The National Institutes of Health (NIH) Roadmap places special emphasis on “bench-to-bedside” research, or the “translation” of basic science research into practical clinical applications.
Weber, Griffin M
core   +2 more sources

Arylbenzazepines Are Potent Modulators for the Delayed Rectifier K+ Channel: A Potential Mechanism for Their Neuroprotective Effects [PDF]

open access: yes, 2010
(±) SKF83959, like many other arylbenzazepines, elicits powerful neuroprotection in vitro and in vivo. The neuroprotective action of the compound was found to partially depend on its D1-like dopamine receptor agonistic activity. The precise mechanism for
Bernhard, Eric J.   +7 more
core   +1 more source

Pharmaceutically relevant (hetero)cyclic compounds and natural products from lignin-derived monomers:Present and perspectives [PDF]

open access: yes, 2021
Lignin, the richest source of renewable aromatics on the planet, is an intriguing raw material for the construction of value-added aromatics. In the past decade, much progress has been made regarding the development of efficient lignin depolymerization ...
Afanasenko, Anastasiia, Barta, Katalin
core   +1 more source

Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists. [PDF]

open access: yes, 2015
A series of pyrido[3,4-d]azepines that are potent and selective 5-HT2C receptor agonists is disclosed. Compound 7 (PF-04781340) is identified as a suitable lead owing to good 5-HT2C potency, selectivity over 5-HT2B agonism, and in vitro ADME properties ...
Allwood, Daniel M   +11 more
core   +4 more sources

Benzo‐fused Nitrogen Heterocycles by Asymmetric Ring Expansion and Stereochemically Retentive Re‐contraction of Cyclic Ureas

open access: yesAngewandte Chemie, Volume 136, Issue 12, March 18, 2024.
Asymmetric deprotonation of N‐benzyl urea derivatives of nitrogen heterocycles leads to enantioselective insertion of the benzylic substituent into an aromatic C−N bond. Treatment of the ring‐expanded products induces a stereospecific ring‐contraction that results in an overall asymmetric enantioselective one‐carbon enlargement of the heterocycle ...
Rajendra K. Mallick   +2 more
wiley   +2 more sources

Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines [PDF]

open access: yes, 2017
The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. In particular, the tetrahydro-1H-[
Díaz, Amelia   +4 more
core  

Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases. [PDF]

open access: yes, 2016
Notch is a key player in various developmental processes during the embryonic stage as well as in regulating tissue homeostasis, cell differentiation, and stem cell maintenance in adult life.
Dela Golshayan   +6 more
core   +1 more source

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