Results 81 to 90 of about 36,788 (280)

BENZIMIDAZOLE DERIVATIVES WITH POTENTIAL CYTOTOXIC ACTIVITY -SYNTHESIS AND THEIR STRUCTURE-ACTIVITY RELATIONSHIP

FUUAST Journal of Biology, 2013
Benzimidazole is an important class of compounds with a wide spectrum of biological activity. This five membered heterocyclic moiety confer for various biological activities.
ARFA KAMIL, SHAMIM AKHTAR, ANEELA KARIM, AHSAAN AHMED, MEHWISH WAJDI, ZAHID KHAN, ZAHID KHAN, SAEED SAIFY   +7 more
doaj  

Unraveling the mechanisms of benzimidazole resistance in hookworms: A molecular docking and dynamics study

Journal of Genetic Engineering and Biotechnology
Background: Benzimidazole resistance is an emerging challenge among parasitic helminths. It is caused by single nucleotide polymorphisms (SNPs) in specific loci in helminths’ β-tubulin genes.
Jan Clyden B. Tenorio, Muhammad Fikri Heikal, Alok Kafle, Mark Andrian B. Macalalad, Fredmoore L. Orosco, Prasert Saichua, Sutas Suttiprapa   +6 more
doaj   +1 more source

Bis(phenolate) N‐Heterocyclic Carbene [OCO] Pincer Ligands: A Unique Family for the Stabilization of Transition Metal Centers and Main Group Elements

ChemistryEurope, EarlyView.
This review highlights the coordination chemistry of NHC bis‐phenolate ligands with metal centers, emphasizing structural features, redox and optical properties, and catalytic applications. Key roles in polymerization, nitrogen reduction catalysis, and small molecule activation are discussed, showcasing the versatility and potential of [OCO]M complexes
Johanna Frey, Soussana Azar, Samuel Dagorne, Stéphane Bellemin‐Laponnaz   +3 more
wiley   +1 more source

Evolved DNAzymes and Stable Activation Chemistry Enable High‐Efficiency DNA Ligation

Chemistry – A European Journal, EarlyView.
In vitro selection of pre‐structured DNA libraries and chemical screening of alternative activation groups yielded trans‐acting DNAzymes with faster ligation rates and enhanced DNA substrate stability. The combination of C3S1 DNAzymes and phosphobenzimidazole‐activated DNA substrates provides improved DNA ligation performance, offering promise for ...
Connor Nurmi, Gemma Mendonsa, Mengdi Bao, Yingfu Li   +3 more
wiley   +1 more source

Triggering and Preventing Cyclization of o‐Amino‐Guanidinobenzenes to 2‐Amino‐Benzimidazoles

Chemistry – A European Journal, EarlyView.
o‐Amino‐guanidinobenzenes are generally prone to cyclization to 2‐amino‐benzimidazoles. In this work, strategies to prevent such cyclizations are developed, allowing to use these compounds as ligands in coordination chemistry and for the design of novel (unsymmetrical) redox‐active ligands.
Carmen L. M. Henel, Edwin Michel, Devin Zeitler, Olaf Hübner, Elisabeth Kaifer, Hans‐Jörg Himmel   +5 more
wiley   +1 more source

An Achiral Tetradentate Cis‐α‐Coordinating NCCN Ligand Gives Rise to a Configurationally Stable Chiral‐at‐Iron Complex for Enantioselective Catalysis

Chemistry – A European Journal, EarlyView.
The design and synthesis of a linear tetradentate NCCN ligand incorporating two 1,2,3‐triazolin‐5‐ylidene mesoionic carbene donors, and its application to asymmetric iron catalysis is reported. This work represents the first example of an iron complex derived from a cis‐α‐coordinating tetradentate NCCN ligand, and notably, the first chiral iron ...
Lukas Hinterlang, Nemrud Demirel, Sergei I. Ivlev, Eric Meggers   +3 more
wiley   +1 more source

Serious adverse events reported with benzimidazole derivatives: A disproportionality analysis from the World Health Organization's pharmacovigilance database.

PLoS Neglected Tropical Diseases
BackgroundBenzimidazole derivatives are widely used anthelmintic drugs, particularly in mass campaigns for intestinal parasitosis treatment. Despite their generally good safety profile, serious adverse reactions have been reported.
Pamella Modingam, Jean-Luc Faillie, Jérémy T Campillo   +2 more
doaj   +1 more source

Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives [PDF]

, 2016
Taghreed H. El-Sayed, Asmaa Aboelnaga, Mohamed Hagar   +2 more
openalex   +1 more source

Glyoxalase‐1 Inhibition Leads to Ferroptosis Induction in Lung Cancer Cells: A Dual Mechanism of Action of Hydroxamic Acids Derived from Cysteine

ChemMedChem, EarlyView.
A set of three cysteine‐derived hydroxamic acids were synthesized and evaluated for human gloxalase‐1 inhibition and ferroptosis induction activities. Among them, compound 2 exhibited a potent inhibitory effect against human glyoxalase‐1 and induced ferroptosis in non‐small cell lung cancer cell lines, increasing reactive oxygen species production and ...
Josué Martínez‐Miranda, Dolores Aguilar‐Cázares, Angélica Flores–Flores, Miguel Ángel Santos‐Contreras, José S. López‐González, Rodrigo Aguayo‐Ortiz, Rogélio Hernández‐Pando, Francisco Hernández‐Luis   +7 more
wiley   +1 more source

SPECTRUM AND CHARACTERISTICS OF THE VIRUS INHIBITORY ACTION OF 2-(α-HYDROXYBENZYL)-BENZIMIDAZOLE [PDF]

, 1961
Hans J. Eggers, Igor Tamm
openalex   +1 more source