Results 121 to 130 of about 17,710 (239)

Synthesis and biological characterization of 4,4‐difluoro‐3(phenoxymethyl)piperidine scaffold as dopamine 4 receptor (D4R) antagonist in vitro tool compounds

ChemMedChem, Accepted Article.
We report the discovery and characterization of a novel series of 4,4‐difluoropiperidine etherbased dopamine D4 receptor antagonists. Structure‐activity relationship studies led to the identification of compound 14a, which displays exceptional binding affinity for the D4 receptor (Ki = 0.3 nM) and remarkable selectivity over other dopamine receptor ...
Saeedeh Saeedi, Sumaiya Nahid, Anish Vadukoot, Corey R Hopkins   +3 more
wiley   +1 more source

Benzimidazole N-Oxides. IV. 1, 3-Dipolar Cycloaddition Reaction with 1-Methylbenzimidazole 3-Oxide

, 1964
Shirō Takahashi, Hideo Kan̄o
openalex   +2 more sources

Impact of Chelation on Reactivity and Cytotoxicity of Hemilabile Biphenyl Gold(III) N‐Heterocyclic Carbene Complexes

ChemMedChem, EarlyView.
An array of eight pairs of biphenyl gold(III) complexes comprising NHC–pyridine ligands having a hemilabile character in vitro displays antiproliferative activity toward human cells in the low micromolar range which is exclusively due to their neutral open form according to speciation studies.
Tom Lacoma, Jérémy Forté, Régina Maruchenko, Romain Morichon, Michèle Salmain, Joëlle Sobczak‐Thépot, Benoît Bertrand   +6 more
wiley   +1 more source

Benzimidazole N-Oxides. VIII. The Reactivity of Ethyl 1-Methyl-2-benzimidazolecarboxylate 3-Oxide and the Related Compounds

, 1968
Shirō Takahashi, Hideo Kan̄o
openalex   +2 more sources

Synthesis of 2-(2-Ethylamino-4-methylthylthiazol-5-yl-)benzimidazole [PDF]

, 1966
J. M. Singh, G. R. chaudhry
openalex   +1 more source

Compression‐Induced Amorphization of ZIF‐62 Leading to Formation of Porous Glass: Overcoming the Limitations of Current Methods

Chemistry–Methods, EarlyView.
Nonhydrostatic compression in steps is applied to transform crystalline zeolitic imidazolate framework‐62 into glass at room temperature. This method overcomes the limitations of existing approaches. This research reveals the mechanism of this phase transformation, including modifications in porosity, using various techniques, particularly positron ...
Jaideep Mor, Renjith B. Nelliyil, Ravi Kumar, Amit Verma, Sandeep Kumar Sharma   +4 more
wiley   +1 more source

A New Benzimidazole Antiemetic, Domperidone, for the Treatment of Postoperative Nausea and Vomiting [PDF]

, 1978
Robert J. Fragen, Nancy J. Caldwell
openalex   +1 more source

QTAIM Analysis of a [2]Rotaxane Molecular Shuttle with a 2,2′‐Bipyridyl Rigid Core

ChemPhysChem, EarlyView.
Supramolecular assembly of a rigid H‐shaped [2]rotaxane composed of 24C8 macrocycle on a molecular thread containing two benzimidazole recognition sites and a central 2,2’‐bipyridyl core is investigated by combining QTAIM with DFT algorithms. The derived interaction patterns shed some light on the mutual position of the 24C8 ring along the axle ...
Costantino Zazza, Nico Sanna, Stefano Borocci, Felice Grandinetti   +3 more
wiley   +1 more source

Studies on Protein-Sulfhydryl Reagents. I. Synthesis of Benzimidazole Derivatives of Maleimide ; Fluorescent Labeling of Maleimide.

, 1964
Yuichi Kanaoka, Takamitsu Sekine, Minoru Machida, Yaeko Soma, Kazutaka Tanizawa, Yoshio Ban   +5 more
openalex   +2 more sources

Injectable benzimidazole anthelmintics effective against liver flukes, tapeworms, lungworms and gastrointestinal roundworms [PDF]

, 1978
Larry R. Cruthers, R. D. HAUGWITZ, M. Haslanger, Bruno Maurer, James Watrous, W. H. Linkenheimer   +5 more
openalex   +1 more source