Results 31 to 40 of about 40,476 (314)

Zirconyl (IV) Nitrate as Efficient and Reusable Solid Lewis Acid Catalyst for the Synthesis of Benzimidazole Derivatives

Journal of Chemistry, 2013
The present paper introduces a simple and efficient method for the synthesis of substituted benzimidazoles by heterocyclization of different o-phenylenediamines and substituted aromatic carboxylic acid/aldehyde in the presence of zirconyl nitrate as ...
Pratapsinha B. Gorepatil, Yogesh D. Mane, Vilas S. Ingle   +2 more
doaj   +1 more source

In Vitro Study of Benzimidazole Derivatives, Tetrahydropyrimidines and Macrocyclic Lactones Therapeutic Efficacy in Dog Hookworms

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Veterinary Medicine, 2018
The study was conducted using faecal samples from 62 dogs. We tested the ovicidal and larvicidal effects of albendazole (ABZ), mebendazole (MBZ), fenbendazole (FBZ) and flubendazole (FLU) by Egg hatch assay (EHA) and larval development assay (LDA).
Laura CĂTANĂ, Raul CĂTANĂ, Roxana CORA, Ştefan RĂILEANU, Mihai CERNEA   +4 more
doaj   +1 more source

The Highly Efficient Synthesis of 1,2-Disubstituted Benzimidazoles Using Microwave Irradiation

Molecules, 2022
The benzimidazole ring of the heterocyclic pharmacophores is one of the most widespread and studied systems in nature. The benzimidazole derivative synthesis study is a crucial point for the development of a clinically available benzimidazole-based drug.
Monica Nardi, Sonia Bonacci, Natividad Herrera Cano, Manuela Oliverio, Antonio Procopio   +4 more
doaj   +1 more source

Reactions of 2-carbonyl- and 2-hydroxy(or methoxy)alkyl-substituted benzimidazoles with arenes in the superacid CF3SO3H. NMR and DFT studies of dicationic electrophilic species

Beilstein Journal of Organic Chemistry, 2019
Reactions of 2-carbonyl- and 2-hydroxy(or methoxy)alkylbenzimidazoles with arenes in the Brønsted superacid TfOH resulted in the formation of the corresponding Friedel–Crafts reaction products, 2-diarylmethyl and 2-arylmethyl-substituted benzimidazoles ...
Dmitry S. Ryabukhin, Alexey N. Turdakov, Natalia S. Soldatova, Mikhail O. Kompanets, Alexander Yu. Ivanov, Irina A. Boyarskaya, Aleksander V. Vasilyev   +6 more
doaj   +1 more source

Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults

Veterinary Research, 2020
The efficacy of anthelmintic therapy of farm animals rapidly decreases due to drug resistance development in helminths. In resistant isolates, the increased expression and activity of drug-metabolizing enzymes (DMEs), e.g.
Pavlína Kellerová, Lucie Raisová Stuchlíková, Petra Matoušková, Karolína Štěrbová, Jiří Lamka, Martina Navrátilová, Ivan Vokřál, Barbora Szotáková, Lenka Skálová   +8 more
doaj   +1 more source

Therapy and Prevention for Human Toxocariasis

Microorganisms, 2022
For the last four decades, knowledge about human toxocariasis with regard to its epidemiology, pathophysiology, clinical spectrum, and imaging or laboratory diagnosis has substantially progressed.
Jean-François Magnaval, Emilie Bouhsira, Judith Fillaux   +2 more
doaj   +1 more source

First Report of Anthelmintic Resistance in Gastrointestinal Nematodes in Goats in Romania

Animals, 2021
Currently, there are three classes of anthelmintics most commonly used in small ruminants: the benzimidazoles (BZs), macrocyclic lactones (MLs) and cholinergic agonists (especially levamisole; LEV).
Adrian Valentin Potârniche, Marcin Mickiewicz, Diana Olah, Constantin Cerbu, Marina Spînu, Attila Hari, Adriana Györke, Agata Moroz, Michał Czopowicz, Marián Várady, Jarosław Kaba   +10 more
doaj   +1 more source

Boric Acid Catalyzed Convenient Synthesis of Benzimidazoles in Aqueous Media

Journal of Chemistry, 2013
Synthesis of benzimidazoles has been developed by the o-phenylenediamine with aldehydes using boric acid an efficient catalyst under mild reaction conditions in aqueous media. The product is applicable to aryl and heteroaryl aldehydes.
Mohammad Reza Poor Heravi, Marjan Ashori
doaj   +1 more source

Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation

Beilstein Journal of Organic Chemistry, 2020
Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ...
Kumar Godugu, Venkata Divya Sri Yadala, Mohammad Khaja Mohinuddin Pinjari, Trivikram Reddy Gundala, Lakshmi Reddy Sanapareddy, Chinna Gangi Reddy Nallagondu   +5 more
doaj   +1 more source

Fighting Antibiotic Resistance: New Pyrimidine-Clubbed Benzimidazole Derivatives as Potential DHFR Inhibitors

Molecules, 2023
The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors.
M. Akiful Haque, Akash Marathakam, Ritesh Rana, Samar J Almehmadi, Vishal B. Tambe, Manoj S. Charde, Fahadul Islam, Falak A. Siddiqui, Giulia Culletta, Anna Maria Almerico, Marco Tutone, Sharuk L. Khan   +11 more
doaj   +1 more source