Results 11 to 20 of about 138,894 (338)

Alcohol or Benzodiazepine Co-involvement With Opioid Overdose Deaths in the United States, 1999-2017

JAMA Network Open, 2020
This cross-sectional analysis assesses the prevalence and number of alcohol- or benzodiazepine-involved opioid overdose deaths by opioid subtypes in the United States from 1999 to 2017.
Marco E. Tori, Marc R. Larochelle, T. Naimi   +2 more
semanticscholar   +1 more source

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria [PDF]

, 2016
The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane (OMM) of cells and is readily up-regulated under various pathological conditions such as cancer, inflammation, mechanical lesions and neurological diseases. Able to bind
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core   +1 more source

Epidemiologic assessment of benzodiazepine exposure among suicide deaths in Colorado, 2015–2017

BMC Public Health, 2020
Background Suicide rates have been climbing in the U.S., particularly in Rocky Mountain states such as Colorado. Benzodiazepines have been linked with suicidal ideation, but there have been few population level assessments of this link.
Tista Ghosh, Kirk Bol, Maria Butler, Barbara Gabella, Andrea Kingcade, Gabriel Kaplan, Lindsey Myers   +6 more
doaj   +1 more source

Older adults and withdrawal from benzodiazepine hypnotics in general practice: effects on cognitive function, sleep, mood and quality of life [PDF]

, 2003
Background: Older adults are the main recipients of repeat prescriptions for benzodiazepine (BZD) hypnotics. BZDs can impair cognitive function and may not aid sleep when taken continuously for years.
Collins, R., Curran, H.V., Fletcher, S., Iliffe, S., Kee, S.C.Y., Woods, B.   +5 more
core   +1 more source

Benzodiazepine Use and Misuse Among Adults in the United States.

Psychiatric Services, 2019
OBJECTIVE: Goals were to determine the prevalence of benzodiazepine use (as prescribed and misuse), characterize misuse, and examine variation by age. METHODS: A cross-sectional analysis was conducted of 2015 and 2016 National Survey on Drug Use and ...
D. Maust, L. Lin, F. Blow
semanticscholar   +1 more source

Association Between Benzodiazepine Use With or Without Opioid Use and All-Cause Mortality in the United States, 1999-2015

JAMA Network Open, 2020
Key Points Question Is benzodiazepine use, with or without opioid use, an independent risk factor for all-cause mortality or a marker for underlying conditions associated with death?
K. Xu, Sarah M. Hartz, J. Borodovsky, L. Bierut, R. Grucza   +4 more
semanticscholar   +1 more source

Impaired Cognitive Function and Hippocampal Changes Following Chronic Diazepam Treatment in Middle-Aged Mice

Frontiers in Aging Neuroscience, 2021
Background: Gamma-aminobutyric acid (GABA) type A receptors are positively allosterically modulated by benzodiazepine binding, leading to a potentiated response to GABA.
Tomonori Furukawa, Yoshikazu Nikaido, Yoshikazu Nikaido, Shuji Shimoyama, Shuji Shimoyama, Nozomu Masuyama, Ayaka Notoya, Shinya Ueno, Shinya Ueno   +8 more
doaj   +1 more source

Potentially inappropriate prescribing in nursing home residents detected with the community pharmacist specific GheOP3S-tool [PDF]

, 2016
Background: The Ghent Older People’s Prescriptions community Pharmacy Screening (GheOP3S-)tool was recently developed to screen for potentially inappropriate prescribing (PIP).
Boussery, Koen, Mattelin, Kristof, Mehuys, Els, PATTYN, EVA, Petrovic, Mirko, Somers, Annemie, Tommelein, Eline, Van Damme, Charlotte   +7 more
core   +1 more source

Patterns in Outpatient Benzodiazepine Prescribing in the United States

JAMA Network Open, 2019
Key Points Question How are benzodiazepines being prescribed, and how have prescribing patterns changed over time? Findings In this serial cross-sectional study of 386 457 ambulatory care visits from 2003 through 2015, the use of benzodiazepines in ...
Sumit D. Agarwal, B. Landon
semanticscholar   +1 more source

Withdrawal-induced delirium associated with a benzodiazepine switch: a case report

Journal of Medical Case Reports, 2011
Introduction Introduced in the early 1960s, diazepam remains among the most frequently prescribed benzodiazepine-type sedatives and hypnotics. Patients with chronic use of short-acting benzodiazepines are frequently switched to diazepam because the ...
Bosshart Herbert
doaj   +1 more source