ELISA detection of phenazepam, etizolam, pyrazolam, flubromazepam, diclazepam and delorazepam in blood using Immunalysis® benzodiazepine kit [PDF]
Journal of Analytical Toxicology, 2015 Phenazepam and etizolam were the first uncontrolled benzodiazepines available for sale in the UK. Pyrazolam, flubromazepam and diclazepam are not used medicinally anywhere in the world; they are produced exclusively for the uncontrolled, recreational ...
Mckeown, Denise A. +2 more
core +3 more sources
Exposure-Response Association Between Concurrent Opioid and Benzodiazepine Use and Risk of Opioid-Related Overdose in Medicare Part D Beneficiaries [PDF]
JAMA Network Open, 2018 Key Points Question How does the risk of overdose change with the number of days with concurrent opioid and benzodiazepine use? Findings In this cohort study of US Medicare data, the overdose risk associated with concurrent benzodiazepine use changed ...
Inmaculada Hernandez +3 more
openalex +2 more sources
Patterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial
Epilepsia, 2021 This study was undertaken to describe patterns of benzodiazepine use as first‐line treatment of status epilepticus (SE) and test the association of benzodiazepine doses with response to second‐line agents in patients enrolled in the Established Status ...
A. Sathe +14 more
semanticscholar +1 more source
Benzodiazepine Misuse: An Epidemic Within a Pandemic
Cureus, 2021 Coronavirus disease 2019 (COVID-19) had deleterious effects on patients with mental health problems and several studies have shown a spike in the rates of depression, insomnia, and post-traumatic stress disorder.
A. Sarangi, T. Mcmahon, J. Gude
semanticscholar +1 more source
Alcohol or Benzodiazepine Co-involvement With Opioid Overdose Deaths in the United States, 1999-2017
JAMA Network Open, 2020 This cross-sectional analysis assesses the prevalence and number of alcohol- or benzodiazepine-involved opioid overdose deaths by opioid subtypes in the United States from 1999 to 2017.
Marco E. Tori +2 more
semanticscholar +1 more source
Benzodiazepine Use and Misuse Among Adults in the United States.
Psychiatric Services, 2019 OBJECTIVE: Goals were to determine the prevalence of benzodiazepine use (as prescribed and misuse), characterize misuse, and examine variation by age. METHODS: A cross-sectional analysis was conducted of 2015 and 2016 National Survey on Drug Use and ...
D. Maust, L. Lin, F. Blow
semanticscholar +1 more source
JAMA Network Open, 2020 Key Points Question Is benzodiazepine use, with or without opioid use, an independent risk factor for all-cause mortality or a marker for underlying conditions associated with death?
K. Xu +4 more
semanticscholar +1 more source
Patterns in Outpatient Benzodiazepine Prescribing in the United States
JAMA Network Open, 2019 Key Points Question How are benzodiazepines being prescribed, and how have prescribing patterns changed over time? Findings In this serial cross-sectional study of 386 457 ambulatory care visits from 2003 through 2015, the use of benzodiazepines in ...
Sumit D. Agarwal, B. Landon
semanticscholar +1 more source
TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control [PDF]
, 2014 The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ...
Anholt R +22 more
core +2 more sources
Is Zolpidem Associated with Increased Risk of Fractures in the Elderly with Sleep Disorders? A Nationwide Case Cross-Over Study in Taiwan. [PDF]
PLoS ONE, 2015 We conducted a study using a case-crossover design to clarify the risk of acute effects of zolpidem and benzodiazepine on all-sites of fractures in the elderly.Case-crossover design.Elderly enrollees (n = 6010) in Taiwan's National Health Insurance ...
Yih-Jing Tang +11 more
doaj +1 more source