Results 21 to 30 of about 66,661 (195)

Current state of hypnotic use disorders: Results of a survey using the Japanese version of Benzodiazepine Dependence Self‐Report Questionnaire

Neuropsychopharmacology Reports, 2021
Aims Benzodiazepine receptor agonists (BZ‐RAs) are frequently prescribed to treat insomnia; however, their long‐term use is not recommended. To introduce an appropriate pharmaco‐therapy, the current state and background factors of BZ‐RAs' dependence must
Mai Yamamoto, Ken Inada, Minori Enomoto, Mitsunari Habukawa, Takahisa Hirose, Yuichi Inoue, Jun Ishigooka, Yuichi Kamei, Tsuyoshi Kitajima, Masayuki Miyamoto, Hideto Shinno, Katsuji Nishimura, Motohiro Ozone, Masahiro Takeshima, Mayumi Suzuki, Hidehisa Yamashita, Kazuo Mishima   +16 more
doaj   +1 more source

Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication

Frontiers in Psychiatry, 2021
In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification
Guoying Wang, Wolfgang Weber-Fahr, Ulrich Frischknecht, Ulrich Frischknecht, Derik Hermann, Derik Hermann, Falk Kiefer, Gabriele Ende, Markus Sack   +8 more
doaj   +1 more source

New benzodiazepine and Z-hypnotic users and disability pension: an eight-year nationwide observational follow-up study

Scandinavian Journal of Primary Health Care, 2017
Objective: To compare how newly initiated treatment with benzodiazepines, Z-hypnotics or both associates with the reception of disability pension among 40,661 individuals of a working age. Design: Prescription register study.
Ingunn F. Tvete, Trine Bjørner, Tor Skomedal   +2 more
doaj   +1 more source

Assessing the clinical utility of the severity dependence scale for benzodiazepine use disorder

South African Journal of Psychiatry, 2021
Background: Benzodiazepines are often used as a part of mental health pharmacological management; however, often when prescribed for extended periods, they increase the risk of benzodiazepine use disorder (BUD).
Karishma Lowton, Gaveeta Chiba
doaj   +1 more source

Zolpidem Profoundly Augments Spared Tonic GABAAR Signaling in Dentate Granule Cells Ipsilateral to Controlled Cortical Impact Brain Injury in Mice

Frontiers in Systems Neuroscience, 2022
Type A GABA receptors (GABAARs) are pentameric combinations of protein subunits that give rise to tonic (ITonicGABA) and phasic (i.e., synaptic; ISynapticGABA) forms of inhibitory GABAAR signaling in the central nervous system.
Jeffery A. Boychuk, Jeffery A. Boychuk, Corwin R. Butler, Corwin R. Butler, Katalin Cs. Smith, Katalin Cs. Smith, Miklos B. Halmos, Bret N. Smith, Bret N. Smith, Bret N. Smith, Bret N. Smith   +10 more
doaj   +1 more source

Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABA_A Receptors

Brain Sciences, 2020
Gamma-aminobutyric acid, type A (GABAA) receptors are complex heterogeneous pentamers with various drug binding sites. Several lines of evidence suggest that benzodiazepines modulate certain GABAA receptors in a flumazenil-insensitive manner, possibly ...
Jing-Jing Lian, Yan-Qing Cao, Yu-Lei Li, Gang Yu, Rui-Bin Su   +4 more
doaj   +1 more source

‘We need more support and doctors that understand the process of tapering …’: A content analysis of free‐text responses to a questionnaire on discontinuing long‐term benzodiazepine receptor agonist use

Health Expectations
Background Many individuals worldwide continue to take benzodiazepine receptor agonists (BZRAs) long term (≥3 months). The aim of this study was to conduct a content analysis of the views and experiences of discontinuing long‐term BZRA use as documented ...
Tom Lynch, Cristín Ryan, Christy Huff, D. E. Foster, Cathal Cadogan   +4 more
doaj   +1 more source

Benzodiazepine Use Disorder Observed and Diagnosed in a Tertiary Care Pediatric Specialty Clinic: A Descriptive Retrospective Chart Review

BJPsych Open
Aims Objectives: In youth and young adults, it is common to encounter non-medical use of benzodiazepines, defined as use without a prescription or use for reasons other than that for which the medication is intended.
Alex Smithers, Laura Miller, Melanie MacInnis, Selene Etches   +3 more
doaj   +1 more source

Benzodiazepine usage and patient preference for alternative therapies: A descriptive study

Health Science Reports, 2019
Background and aims The prevalence of chronic benzodiazepine use in primary care settings remains high despite clear evidence of adverse health outcomes resulting from long‐term use and the availability of effective alternative behavioural therapies ...
Fatema‐Tun‐Naher Sake, Keith Wong, Delwyn J. Bartlett, Bandana Saini   +3 more
doaj   +1 more source

Addressing the Issue of Chronic, Inappropriate Benzodiazepine Use: How Can Pharmacists Play a Role?

Pharmacy, 2013
Prescribing guidelines do not recommend the long-term use of benzodiazepines since their effectiveness with chronic use is out-weighed by risks including dependence, memory and cognitive impairment, hip fractures and traffic accidents.
Helen C. Gallagher
doaj   +1 more source