Results 31 to 40 of about 156,110 (291)
Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. [PDF]
, 2017 A key goal of diabetes research is to develop treatments to safely promote human ß-cell replication. It has recently become appreciated that activation of γ-aminobutyric acid receptors (GABA-Rs) on ß-cells can promote their survival and replication.
Dang, Hoa +3 more
core +1 more source
Assessing the clinical utility of the severity dependence scale for benzodiazepine use disorder
South African Journal of Psychiatry, 2021 Background: Benzodiazepines are often used as a part of mental health pharmacological management; however, often when prescribed for extended periods, they increase the risk of benzodiazepine use disorder (BUD).
Karishma Lowton, Gaveeta Chiba
doaj +1 more source
An index of fatal toxicity for new psychoactive substances [PDF]
, 2018 The final, definitive version of this paper has been published in Journal of Psychopharmacology, February 2018, published by SAGE Publishing, All rights reserved.An index of fatal toxicity for new psychoactive substances has been developed based solely ...
Corkery, John, King, L.A.
core +2 more sources
Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]
, 2020 OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A +3 more
core +2 more sources
Scandinavian Journal of Primary Health Care, 2017 Objective: To compare how newly initiated treatment with benzodiazepines, Z-hypnotics or both associates with the reception of disability pension among 40,661 individuals of a working age. Design: Prescription register study.
Ingunn F. Tvete +2 more
doaj +1 more source
Visualizing mitochondrial FoF1-ATP synthase as the target of the immunomodulatory drug Bz-423
, 2018 Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immuno-modulatory compound Bz-423 is such a drug that binds to subunit
Börsch, Michael +2 more
core +1 more source
Effects of insecticidal ketones present in mint plants on GABA A receptor from mammalian neurons [PDF]
, 2017 The genus Mentha, an important member of the Lamiaceae family, is represented by many species commonly known as mint. The insecticidal activity of Mentha oil and its main components has been tested and established against various insects/pests.
Delgado Marín, Leticia Ester +2 more
core +2 more sources
Health ExpectationsBackground Many individuals worldwide continue to take benzodiazepine receptor agonists (BZRAs) long term (≥3 months). The aim of this study was to conduct a content analysis of the views and experiences of discontinuing long‐term BZRA use as documented ...
Tom Lynch +4 more
doaj +1 more source
Influence of SSRI and SNRI co-prescription on benzodiazepine prescription trajectories
Drug and Alcohol Dependence ReportsPurpose: This study examined whether co-prescription of selective serotonin reuptake inhibitors (SSRIs) or serotonin or norepinephrine reuptake inhibitors (SNRI)s with benzodiazepines is associated with differences in benzodiazepine prescriptions both ...
Kerry L. Kinney +4 more
doaj +1 more source
The Prevalence of Benzodiazepine Usage Among Cardiovascular Patients [PDF]
مجله علوم پزشکی صدراIntroduction: Both benzodiazepines and cardiovascular disease independently increase dementia risk, while anxiety and other psychiatric disorders may exacerbate cardiovascular diseases.
Vahid Mohammadkarimi +7 more
doaj +1 more source