Results 61 to 70 of about 153,478 (337)

Synthetic epoxy-pregnan steroids: effects on anxiety behavior in rats [PDF]

, 2016
Neurosteroids like 3α-OH-5α-pregnan-20-one (allopregnanolone) and 3α-OH-5β-pregnan-20-one (pregnanolone) modulate the γ-aminobutyric acid-A (GABAA) receptor function and produce several effects that can be considered for therapeutical pruposes like ...
Coirini, Hector, Ghini, Alberto Antonio, Rey, Mariana   +2 more
core   +1 more source

Short communication: Dynamic chemical labelling allows the measurement of the paracetamol toxicity biomarker microRNA‐122 in hospital clinical laboratories

British Journal of Clinical Pharmacology, EarlyView.
MicroRNA‐122 (miR‐122) is a sensitive biomarker for paracetamol‐induced liver injury. This study assessed the diagnostic performance of dynamic chemical labelling (DCL) combined with an immunoassay platform to quantify miR‐122 in human serum, as a proof‐of‐concept for hospital use.
Samar Alzeer, Antonio Marin‐Romero, Bárbara López‐Longarela, Juan J. Guardia‐Monteagudo, F. Javier Lopez‐Delgado, Salvatore Pernagallo, Juan J. Diaz‐Mochon, Mavys Tabraue‐Chavez, Kathleen Scullion, James W. Dear   +9 more
wiley   +1 more source

Research on 1H NMR spectrum optimization of 2,3-benzodiazepines based on conformational isomerism

Results in Chemistry
To address the issue of multiple sets of signal peaks and irregular peak shapes in the 1H NMR spectra of some 2,3-benzodiazepines due to conformational isomerism, 1H NMR experiments were conducted using 2,3-benzodiazepines 1 as examples, with variations ...
Fei Zhang, Ya-Li Ding
doaj   +1 more source

The emergence of new psychoactive substance (NPS) benzodiazepines: a review [PDF]

, 2017
The market for new psychoactive substances has increased markedly in recent years and there is now a steady stream of compounds appearing every year.
Ajir, Akerman, Anzillotti, Artemenko, Bachhuber, Barzaghi, Bergstrand, Bertilsson, Bertolino, Borea, Bourcier, Boxenbaum, Breimer, Broséus, Casacchiaa, Casellas, Childress, Chong, Coassolo, Court, Court, Crichton, Drummer, El Balkhi, El Balkhi, El Mahjoub, Famiglini, File, Fischer-Cornelssen, Fleishaker, Fleishaker, Fleishaker, Fracasso, Fraser, Fraser, Fukasawa, Fukasawa, GABAA, Garzone, Gavish, Gavish, Gerhards, Gitto, Goldstein, Greenblatt, Grobin, Haefely, Heikkinen, Heizmann, Hester, Holmes, Horváth, Huppertz, Høiseth, Inoue, Jones, Kapil, Kar, Katselou, Kerrigan, Kintz, Klotz, Kopanitsa, Krasowski, Kriikku, Kroboth, Lambert, Langley, Levine, Lim, Lomas, Lomas, Lukasik-Glebocka, Maddalena, Mandelli, Maskell, McAuleya, McClean, Megarbane, Meguro, Melo, Meyer, Mizuno, Moffat, Moosmann, Moosmann, Moosmann, Moosmann, Mozayani, Nakamae, Nakatsuka, O'Connor, O'Connor, Ochs, Oilman, Olivera, Olsen, Olsen, Olsen, Papadopoulos, Papadopoulos, Parmeggiani, Pellow, Pellow, Peng, Peppers, Persona, Pettersson Bergstrand, Pettersson Bergstrand, Rasanen, Robertson, Roman, Rundfeldt, Rupprecht, Rupprecht, Schwartz, Shearer, Sieghart, Sigel, Simonsen, Skopp, Skopp, Smith, Smith, Smith, So, Sohn, Sonne, Soriano, Stephenson, Sternbach, Tan, Tan, The Drug Enforcement Administration (DEA), Uddin, Usui, Venkatakrishnan, Vikingsson, Vogel, Wang, Westland, Whirl-Carrillo, Whitwam, Xu, Yegles, Zherdev, Zhu, Zhuk, Ékonomov, Чекулаев   +149 more
core   +3 more sources

Machine learning methods for predicting adverse drug events: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo, Fatemeh Ahmadi, Mohammad Ali Omrani, Sheikh S. Abdullah, Neda Rostamzadeh, Atefeh Jafari, Lujain Izzedin, Kamran Sedig, Flory T. Muanda   +8 more
wiley   +1 more source

The pharmacist’s response to the needs of patients undergoing treatment with psychotropic medication [PDF]

, 1999
The usage of psychotropic (Table 1) medication is considerable world wide. In Malta, this can be attested to by the numerous studies that have been conducted by the University of Malta Department of Pharmacy (in conjuction with other institutions and ...
Sant Fournier, Mary Ann
core  

Benzodiazepines and Related Drugs as a Risk Factor in Alzheimer's Disease Dementia

Frontiers in Aging Neuroscience, 2020
Benzodiazepines (BZDs) and Z-drugs are compounds widely prescribed in medical practice due to their anxiolytic, hypnotic, and muscle relaxant properties.
Miren Ettcheto, Miren Ettcheto, Miren Ettcheto, Miren Ettcheto, Jordi Olloquequi, Elena Sánchez-López, Elena Sánchez-López, Elena Sánchez-López, Oriol Busquets, Oriol Busquets, Oriol Busquets, Oriol Busquets, Amanda Cano, Amanda Cano, Amanda Cano, Patricia Regina Manzine, Carlos Beas-Zarate, Rubén D. Castro-Torres, Maria Luisa García, Maria Luisa García, Maria Luisa García, Mónica Bulló, Mónica Bulló, Mónica Bulló, Carme Auladell, Carme Auladell, Carme Auladell, Jaume Folch, Jaume Folch, Antonio Camins, Antonio Camins, Antonio Camins, Antonio Camins   +32 more
doaj   +1 more source

Emerging pharmacotherapy of tinnitus [PDF]

, 2009
Tinnitus, the perception of sound in the absence of an auditory stimulus, is perceived by about 1 in 10 adults, and for at least 1 in 100, tinnitus severely affects their quality of life.
Ana Belén Elgoyhen, Azevedo AA, Bahmad FM, Berthold Langguth, Busto U, Courtney KR, Domeisen H, Feder R, Gananca MM, Goebel G, Goodnick PJ, Gresser U, Guitton MJ, Guitton MJ, Hastak SM, Henry JA, Hilton M, Holstein N, House JW, Kuchar DL, Langguth B, Lenarz T, Mahadevan S, Mardini MK, McCabe BF, Melcher JR, Moller AR, Moller AR, Newman CW, Oliver D, Podoshin L, Richard Salvi, Rogawski MA, Roth SH, Schlee W, Shambaugh GE, Shea JJ, Shulman A, Sieghart W, Tandon R, Wei BPC, Williams SH, Willow M, Zapp JJ   +43 more
core   +1 more source

Toward personalized healthcare: Advances in two‐dimensional nanomaterial‐based flexible electrochemical sensors for physiological monitoring

BMEMat, EarlyView.
This review provides an overview of the properties, composites and application of two‐dimensional (2D) nanomaterials for wearable electrochemical biosensors. Also, the challenges and future prospects of utilizing 2D nanomaterials in wearable electrochemical biosensor applications are discussed.
Kou Zhang, Lu Han, He‐Qing Cai, Xin‐Yu Xue, Yi‐Fei Song, Wu‐Lin Xin, Ying‐Ze Wang, Peng Liu, Juan Liu   +8 more
wiley   +1 more source

Serotonergic Neuromodulation of Natural Products Isoreserpine and Isoreserpiline in Adult Zebrafish: An in Silico and In Vivo Investigation

Chemistry &Biodiversity, EarlyView.
ABSTRACT Anxiety is a multidimensional behavioral disorder widely studied in neuroscience due to the involvement of specific neural circuits. Although benzodiazepines are commonly used, their side effects drive the search for new therapeutic alternatives.
Nádia Aguiar Portela Pinheiro, Ivana Carneiro Romão, Amanda Maria Barros Alves, Sônia Maria Costa Siqueira, Jane Eire Silva Alencar de Menezes, Emmanuel Silva Marinho, Maria Kueirislene Amâncio Ferreira, Márcia Machado Marinho, Herbert de Sousa Magalhães, Andreia Ferreira de Castro Gomes, Otília Deusdênia Loiola Pessoa, Hélcio Silva dos Santos   +11 more
wiley   +1 more source