Results 11 to 20 of about 728 (151)

Role of Endoplasmic Reticulum Stress in Atherosclerosis and Diabetic Macrovascular Complications [PDF]

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Age-related changes in endoplasmic reticulum (ER) are associated with stress of this cell organelle. Unfolded protein response (UPR) is a normal physiological reaction of a cell in order to prevent accumulation of unfolded and misfolded proteins in the ...
Alexander N. Orekhov, Dmitry A. Chistiakov, Igor A. Sobenin, Yuri V. Bobryshev   +3 more
core   +4 more sources

Mannich-Type Condensation and Domino Quinazolinone-Amidine Rearrangement Affords Ring-Fused Mackinazolinones with Anti-Amoebic Activity. [PDF]

Adv Synth Catal, 2023
Abstract A three‐step synthesis of anti‐amoebic, ring‐fused mackinazolinones has been developed. A Mannich‐type reaction between quinazolin‐4‐ones and N‐Cbz propanal in the presence of AgOTf afforded quinazolinones (19–94% isolated yield) bearing a newly formed heterocycle with an alkylamine appendage that, upon N‐Cbz deprotection and basification ...
Lish MS, Milanes JE, Sanders KM, Guzei IA, Morris JC, Golden JE.   +5 more
europepmc   +2 more sources

Synthesis of Indole‐Fused 1,4‐Diazepinones via Photoredox‐Catalyzed Cascade Cyclization Reaction

Advanced Synthesis &Catalysis, Volume 365, Issue 22, Page 3958-3966, November 21, 2023., 2023
Abstract A photoredox‐promoted approach for the synthesis of [1,4]diazepino[1,7‐a]indol‐6(7H)‐ones starting from N‐indolyl phenylacrylamides and aroyl chlorides as radical source is reported. This method, that involves a cascade radical addition on C−C double bond followed by intramolecular cyclization at indole C2‐position, affords two diastereomeric ...
Elisa Brambilla, Silvia Meraviglia, Edoardo Moneta, Donatella Nava, Silvia Rizzato, Giorgio Abbiati, Valentina Pirovano   +6 more
wiley   +1 more source

Anticancer and Antimicrobial Activity of Some New 2,3‐Dihydro‐1,5‐benzodiazepine Derivatives

Heteroatom Chemistry, Volume 2023, Issue 1, 2023., 2023
A series of 2,3‐dihydro‐1,5‐benzodiazepine derivatives have been synthesized and characterized using IR, NMR, GC‐MS, single crystal XRD, and microanalysis. The results of their antibacterial activity against methicillin‐resistance Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis, Streptococcus mutans, Pseudomonas ...
Felix Odame, Tatenda Madanhire, Clement Tettey, David Neglo, Francisca Adzaho, Daniel Sedohia, Eric C. Hosten, Jacek Skarzewski   +7 more
wiley   +1 more source

Catalytic Asymmetric Transfer Hydrogenation of Imines: Recent Advances [PDF]

, 2015
In this review article recent developments in the asymmetric transfer hydrogenation of imines from 2008 up to today are presented. The main methodology involves either metal-catalyzed procedures in the presence of a chiral ligand or organocatalyzed ...
Foubelo, Francisco, Yus, Miguel
core   +3 more sources

Palladium-catalyzed benzodiazepines synthesis [PDF]

, 2020
This review is focused on palladium-catalyzed reactions as efficient strategies aimed at the synthesis of different classes of benzodiazepines. Several reaction typologies are reported including hydroamination, amination, C\u2013H arylation, N-arylation,
E.M. Beccalli, M.S. Christodoulou, S. Giofre   +2 more
core   +1 more source

A diversity of recently reported methodology for asymmetric imine reduction [PDF]

, 2020
This review contains an account of recent developments in catalytic, asymmetric processes reported for the reduction of C=N bonds to amines, in which we have attempted to communicate the remarkable diversity of methods which have been reported in recent ...
Barrios-Rivera, Jonathan, Vyas, Vijyesh K., Wills, Martin, Xu, Yingjian   +3 more
core   +1 more source

Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents [PDF]

, 2022
The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(1H,3H)-dione was optimised. Starting from 4-hydroxyquinolines (4HQs), aminomethylation was carried out via the modified Mannich reaction (mMr) applying ...
Csuvik Oszkár, Spengler Gabriella, Szatmári István, Szemerédi Nikoletta   +3 more
core   +1 more source

A Single‐Stranded DNA‐Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

Advanced Science, Volume 7, Issue 22, November 18, 2020., 2020
A single‐stranded DNA‐encoded chemical library (DEL) of 366 600 compounds, based on a stereoisomeric scaffold and on a single‐stranded DNA format, allows the isolation of ligands against multiple protein targets. The library can also be hybridized to a complementary DNA strand equipped with a protein binder, in order to generate affinity‐matured ...
Gabriele Bassi, Nicholas Favalli, Miriam Vuk, Marco Catalano, Adriano Martinelli, Anika Trenner, Antonio Porro, Su Yang, Chuin Lean Tham, Mustafa Moroglu, Wyatt W. Yue, Stuart J. Conway, Peter K. Vogt, Alessandro A. Sartori, Jörg Scheuermann, Dario Neri   +15 more
wiley   +1 more source

Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity

ChemMedChem, Volume 15, Issue 12, Page 1078-1088, June 17, 2020., 2020
The polyphenolic natural product rottlerin, isolated from Kamala powder, has been used for centuries in traditional Indian medicine. Among other biological effects, rottlerin has been shown to activate KCNQ1 potassium channels. Rottlerin analogues were synthesized and evaluated electrophysiologically in X. laevis oocytes.
Marco Lübke, Julian A. Schreiber, Thang Le Quoc, Florian Körber, Jasmin Müller, Sivatharushan Sivanathan, Veronika Matschke, Janina Schubert, Nathalie Strutz‐Seebohm, Guiscard Seebohm, Jürgen Scherkenbeck   +10 more
wiley   +1 more source