Small molecules, big targets: drug discovery faces the protein-protein interaction challenge. [PDF]
, 2016 Protein-protein interactions (PPIs) are of pivotal importance in the regulation of biological systems and are consequently implicated in the development of disease states.
A Ciulli +171 more
core +2 more sources
Design of Novel Molecular Micelles for Capillary Electrophoresis [PDF]
, 2006 The research presented in this dissertation involves the synthesis, characterization, and application of novel anionic and cationic chiral molecular micelles in capillary electrophoresis (CE) for the separation of diverse chiral compounds.
Rizvi, Syed Asad Ali
core +3 more sources
Synthesis, Characterization and DFT Studies on Some 2,3-Dihydro-4-Methyl-1H-1,5-Benzodiazepinone and N-Isopropenyl Benzimidazolone Derivatives [PDF]
, 2013 Benzodiazepinones and benzimidazolones have been synthesized by the reaction of o-phenylenediamine with ethylacetoacetate in boiling xylene. Alkylation of the obtained compounds was carried out by reaction with excess of ethyl iodide.
Alayed, Abdallah Suliman +2 more
core +1 more source
Convenient two-step synthesis of highly functionalized benzo-fused 1,4-diazepin-3-ones and 1,5-diazocin-4-ones by sequential Ugi and intramolecular SNAr reactions [PDF]
, 2017 Benzodiazepinones are an important family of heterocycles with very attractive pharmacological properties and peptidomimetic abilities. We report herein a rapid and efficient two-step synthesis of polysubstituted 1,4-benzodiazepin-3-ones and 1,5 ...
Biron, Éric +3 more
core +1 more source
Development of certain novel N-(2-(2-(2-oxoindolin-3-ylidene)hydrazinecarbonyl)phenyl)-benzamides and 3-(2-oxoindolin-3-ylideneamino)-2-substituted quinazolin-4(3H)-ones as CFM-1 analogs: design, synthesis, QSAR analysis and anticancer activity. [PDF]
, 2015 The reaction of N-(2-(hydrazinecarbonyl)aryl)benzamides 2a, b with indoline-2,3-diones 4ae in acidified ethanolic solution furnished the corresponding N-(2-(2-(2-oxoindolin-3-ylidene)hydrazinecarbonyl)phenyl)benzamides 5aj, respectively.
Abdel-Aziz, Hatem A. +7 more
core +1 more source
Solvent Effects on Medicinal Structure and 15N NMR Shielding of Medazepam [PDF]
, 2023 The Density Functional Theory (DFT) and Tomasi’s Polarized Continuum Model (PCM) were used to investigate the effects of solvent dielectric constant on the structural stability and 15N NMR tensors of Medazepam (MDZ) drug.
Arezoo Tahan, Fatemeh Alimohammadi
core +1 more source
Two cycles with one catch : hydrazine in Ugi 4-CR and its postcyclizations [PDF]
, 2017 Isocyanide-based multicomponent reactions (IMCR) are by far the most versatile reactions that can construct relatively complex molecules by one-pot synthesis.
Dömling, Alexander +4 more
core +9 more sources
International Journal of Photoenergy, Volume 3, Issue 4, Page 205-211, 2001., 2001 The photostability of selected drug molecules, including furosemide, prochlorperazine, diclofenac, piroxicam, midazolam and nifedipine was studied, the kinetics of photodegradation, identification of the photodegradants investigated and mechanisms of photodegradation proposed.
B. D. Glass +8 more
wiley +1 more source
, 2015 International audienceA new strategy for the synthesis of optically active pyrrolo[ 1,4]benzo- diazepine-2,5-diones has been developed. The approach is based on an initial Michael addition of functionalized 1,2-ketoamides on nitroalkenes, with a ...
Acosta, Paola +6 more
core +4 more sources
Recent Development in Palladium-Catalyzed Domino Reactions: Access to Materials and Biologically Important Carbo- and Heterocycles [PDF]
, 2019 The chemistry of palladium complexes has no limits. Many domino processes (even multicomponent) are continuously appearing in the literature. Carbocyclic and heterocyclic molecules are efficiently prepared under the atom-economy principle using the ...
Dondas, H. Ali +2 more
core +1 more source