Results 31 to 40 of about 728 (151)

N‒substituted 5‒hydroxy‒pyrrol‒2‒ones based cholecystokinin‒2 antagonists as experimental anticancer agents for the treatment of lung cancer [PDF]

, 2018
Background: Cholecystokinin and gastrin are endocrine growths factors for certain tumours and CCK1 R and CCK2R receptors are ideal molecular targets for novel smart chemo‒ therapeutics with a beneficial overall profile due to their anxiolytic and ...
Bock, Chang, Charpentier, Donald, Dourish, Dourish, Evans, GN, Hahne, Herranz, Jorpes, Lattmann, Lattmann, Lattmann, Lattmann, Lattmann, Lattmann, Lattmann, Lattmann, Maton, Mawe, Meyer, Miyazaki, Moody, Offel, Ponnusamy, Saita, Smith   +27 more
core   +1 more source

Electrochemical Intramolecular Aminobromination of Alkenes

European Journal of Organic Chemistry, Volume 29, Issue 2, January 16, 2026.
A versatile electrochemical method for the intramolecular aminobromination of alkenes has been developed. The method provides access to five‐, six‐, and seven‐membered heterocycles by exploiting tetrabutylammonium bromide as an electrolyte and bromine source.
Sara Colombo, Emanuele Cartamina, Marta Papis, Davide Spanu, Leonardo Lo Presti, Giovanni Macetti, Giovanni Poli, Alessandro Contini, Gianluigi Broggini, Camilla Loro   +9 more
wiley   +1 more source

Structure–Activity Relationships of Inactive‐Conformation Binding EGFR Inhibitors: Linking the ATP and Allosteric Pockets

Archiv der Pharmazie, Volume 358, Issue 7, July 2025.
EGFR inhibitors can be made especially effective through binding small‐molecule inhibitors that target the allosteric pocket. Structural and functional analysis affords new insights into the compositions and their molecular connections that afford effective inhibitors. ABSTRACT The epidermal growth factor receptor (EGFR) tyrosine kinase is an important
Surbhi P. Chitnis, Florian Wittlinger, Mareike Möllers, Tyler J. Hartman, Marcel Günther, Michael J. Eck, Stefan A. Laufer, David E. Heppner   +7 more
wiley   +1 more source

The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic [PDF]

, 2019
Human immunodeficiency virus (HIV) infection is now pandemic. Targeting HIV-1 reverse transcriptase (HIV-1 RT) has been considered as one of the most successful targets for the development of anti-HIV treatment.
Byrareddy, Siddappa N., Kongsted, Jacob, Kramer, Victor G., Kurup, Sonali, Liu, Xinyong, Namasivayam, Vigneshwaran, Vanangamudi, Murugesan, Zhan, Peng   +7 more
core   +1 more source

The synthesis of heterocyclic systems for use in biological imaging [PDF]

, 2013
The first research project described in this thesis is the development of new SPECT and PET imaging agents for group II metabotropic glutamate receptors (mGluR2/3).
Gilfillan, Lynne
core  

The Structure of N-Benzylazoles from Pyrrole to Carbazole: Geometries and Energies [PDF]

, 2018
International audienceThe complete series of 18 parents N-benzylazoles (10 azoles and 8 benzazoles) have been calculated at the B3LYP/6-311++G(d,p) level.
Alkorta, Ibon, Claramunt, Rosa M., Elguero, José, Roussel, Christian, Sanz, Dionisia   +4 more
core  

Targeting CBP revers chemoresistance to 5‐FU of CDX2/REG4 double‐positive gastric cancer

Clinical and Translational Medicine, Volume 14, Issue 11, November 2024.
Zhiyuan Fan, Fangyuan Li, Xiao Jiang, Tao Pan, Mingde Zang, Jianfang Li, Beiqin Yu, Qingqing Sang, Wentao Liu, Liping Su, Chen Li, Zhenggang Zhu, Min Yan, Chao Yan, Fei Yuan, Bingya Liu   +15 more
wiley   +1 more source

Syntheses of the Novel Furo [3, 4-b] [1, 5] benzodiazepinone and Pyrrolo [3, 4-b] [1, 5] benzodiazepinone Systems

CHEMICAL & PHARMACEUTICAL BULLETIN, 1984
Synthese par action de l'o-phenylenediamine sur l'acide dimethyl-5,5 tetronique et l'acide dimethyl-5,5 ...
KEIZO MATSUO, KUNIYOSHI TANAKA
openaire   +2 more sources

Design and synthesis of novel 1,4-benzodiazepine surrogates as potential CCKA and CCKB antagonists via palladium-catalyzed three-component cascade reactions [PDF]

, 2018
Structurally diverse novel 1,4-benzodiazepine analogues related to selective CCKA antagonist MK-329, and CCKB antagonists L-365,260 and YM022 are prepared via palladium-catalyzed three component domino reactions involving allenylation-carbonylation-anion
Belveren, S, Dondas, HA, Ferrándiz-Saperas, M, Grigg, R, Kilner, C, Poyraz, S, Sansano, JM, Selva, E   +7 more
core   +3 more sources

Interventions for Complex Traumatic Events (INCiTE): Systematic review and research prioritisation exercise [PDF]

, 2020
Background: People with a history of complex traumatic events typically experience trauma and stressor disorders and additional mental comorbidities. It is not known if existing evidence-based treatments are effective and acceptable for this group of ...
Barbui, Corrado, Churchill, Rachel Christine, Coventry, Peter, Dale, Holly, Gilbody, Simon, Jones-Diette, Julie Susan, Lovell, Karina, McMillan, Dean, Meader, Nicholas, Melton, Hollie Anne, Shah, Iram, Temple, Melanie, Wright, Kath   +12 more
core   +1 more source