Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease [PDF]
, 2017 OBJECTIVE: Patients with Niemann-Pick disease type C1 (NPC1), a lysosomal lipid storage disorder that causes neurodegeneration and liver damage, can present with IBD, but neither the significance nor the functional mechanism of this association is clear.
Bagola, Katrin +27 more
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Design et synthèse d’hétérocycles fusionnés polysubstitués par réaction multicomposante de Ugi en tandem pour le développement d’agents antimicrobiens et antinéoplasiques [PDF]
, 2021 Les benzodiazépines et quinoxalines sont des structures très importantes en chimie médicinale et on les retrouve dans un grand nombre de médicaments commercialisés et cliniquement importants.
Régnier, Noémie
core
Chiroptical Properties and Conformation of 4,5-Saturated Derivatives of 5-Aryl-1,4-benzodiazepin-2-ones [PDF]
, 1989 CD spectra of a series of 5-aryl-7-chloro-l,3,4,5-tetrahydro- 2H-l,4-benzodiazepin-2-one derivatives having different substituents at positions 1, 3, 4, and 5 were studied.
J. G. Angyan +3 more
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Transition metal catalyzed reactions on allenic substrates for heterocyclic synthesis. [PDF]
, 2011 openThe main subject of this thesis are transition metal catalyzed reactions onto allenic substrates. The reactivity of allenic double bonds in presence or absence of transition metal was investigated and studied in order to favor intramolecular ...
Rigamonti, Micol
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SYNTHESIS AND REACTIVITY OF N-CONTAINING HETEROCYCLES THROUGH CATALYTIC SYSTEMS. [PDF]
, 2010 N-containing heterocycles are the more represented in natural products and drugs. Our research has been focused on various aspects of heterocycles synthesis and reactivity. For this purpose we use transition metals catalysis, among which Pd has a central
L. Basolo
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P(III)/P(V) redox cycling catalysis: advances in catalytic Wittig and Appel reactions [PDF]
P(III)/P(V) redox cycling catalysis avoids phosphine oxide waste in reactions by reducing it in situ using silanes as terminal reductants. New methods were developed.
Tönjes, Jan Günther (gnd: 120065160X)
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Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones. [PDF]
ACS Med Chem Lett, 2022 Ryan MC +9 more
europepmc +1 more source
The development and assessment of sustained release nevirapine tablets [PDF]
, 2013 The use of antiretroviral (ARV) agents in the management of HIV/AIDS has significantly improved the lifestyle and wellbeing of patients. Despite the success that has been achieved with the use of ARV therapy, the occurrence of adverse effects and ...
Mwila, Chiluba
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A comprehensive evaluation between dexmedetomidine and midazolam for intraoperative sedation in the elderly: protocol for a systematic review and meta-analysis of randomized controlled trials. [PDF]
Syst Rev, 2022 Huang C +6 more
europepmc +1 more source