Results 21 to 30 of about 600 (168)
Sanguinarine synergistically potentiates aminoglycoside‐mediated bacterial killing
Microbial Biotechnology, Volume 15, Issue 7, Page 2055-2070, July 2022., 2022 Aminoglycosides primarily interact with the bacterial ribosomes and result in protein misfolding and ROS production. Insertion of abnormal proteins into the cell membrane increases the membrane permeability and leads to enhanced uptake of sanguinarine.
Chang Lu +6 more
wiley +1 more source
Characterization of extracts from the bark of the Gabon hazel tree (Coula edulis baill) for antioxidant, antifungal and anti-termite products [PDF]
, 2021 Chemical composition of the bark extracts ofCoula eduliswas inves-tigated tofind potential antioxidant, anti-termite and antifungal compounds whichcanfind useful applications in thefields of food, nutraceuticals, cosmetics or agro-chemical. Phytochemical
Bopenga Bopenga, Christ Stone Arnaud +7 more
core +2 more sources
Structure-function analysis of CYP719As involved in methylenedioxy bridge-formation in the biosynthesis of benzylisoquinoline alkaloids and its de novo production [PDF]
, 2023 Benzylisoquinoline alkaloids (BIAs) are a type of secondary metabolite with clinical application value. (S)-stylopine is a special BIA which contains methylenedioxy bridge structures.
Bu, Junling +14 more
core +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 Inflammatory diseases are a common therapeutic problem and nonsteroidal anti‐inflammatory drugs are not deprived of side effects, of which ulcerogenic activity is one of the most frequent. The aim of the study was to evaluate the anti‐inflammatory activity of the sanguinarine‐chelerythrine (SC) fraction of Coptis chinensis and its influence on the ...
Maciej Danielewski +12 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 The genus Papaver is highly esteemed in the pharmacy industry, in the culinary field, and as ornamental plants. These plants are also valued in traditional medicine. Among all Papaver species, Papaver somniferum L. (opium poppy) is the most important species in supplying phytochemicals for the formulation of drugs, mainly alkaloids like morphine ...
Monica Butnariu +21 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 The upregulation telomerase activity is observed in over 85‐90% of human cancers and provides an attractive target for cancer therapies. The high guanine content in the telomere DNA sequences and the hTERT promoter can form G‐quadruplexes (G4s). Small molecules targeting G4s in telomeres and hTERT promoter could stabilize the G4s and inhibit hTERT ...
Wei Gu +10 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 The medicinal properties of plants can be evolutionarily predicted by phylogeny‐based methods, which, however, have not been used to explore the regularity of therapeutic effects of Chinese plants utilized by ethnic minorities. This study aims at exploring the distribution law of therapeutic efficacy of Ranunculales plants on the phylogenetic tree of ...
Da-Cheng Hao +4 more
wiley +1 more source
Come-back of phenanthridine and phenanthridinium derivatives in 21st century [PDF]
, 2014 Phenanthridine derivatives are one of the most intensively studied families of biologically active compounds with efficient DNA binding ; attracting attention about time of DNA structure discovery (1960ies), early recognized as a symbol of DNA ...
Piantanida, Ivo +2 more
core +2 more sources
Plant Direct, Volume 5, Issue 1, January 2021., 2021 Abstract Basic helix‐loop‐helix (bHLH) transcription factors (TFs) are key regulators of plant specialized metabolites, including terpenoid indole alkaloids (TIAs) in Catharanthus roseus. Two previously characterized subgroup‐IVa bHLH TFs, BIS1 (bHLH Iridoid Synthesis 1) and BIS2 regulate iridoid biosynthesis in the TIA pathway.
Sanjay Kumar Singh +5 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021 Background. Despite the enrollment of new small molecules such as Sorafenib for the treatment of hepatocellular carcinoma (HCC), HCC still remains a significant contributor to cancer‐related mortality and morbidity globally. Zanthoxylum zanthoxyloides is long suspected of possessing anticancer bioactive compounds that may hold the prospect of ...
Desmond Omane Acheampong +6 more
wiley +1 more source