Structure of benzothiadiazine at zwitterionic phospholipid cell membranes [PDF]
The Journal of Chemical Physics, 2021 The use of drugs derived from benzothiadiazine, which is a bicyclic heterocyclic benzene derivative, has become a widespread treatment for diseases such as hypertension (treated with diuretics such as bendroflumethiazide or chlorothiazide), low blood sugar (treated with non-diuretic diazoxide), or the human immunodeficiency virus, among others. In this
Hu, Zheyao +2 more
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Effects of benzothiadiazine drugs on carbohydrate metabolism [PDF]
Metabolism, 1965 Abstract The administration of chlorothiazide both to man and to rats results in hyperglycemia following a glucose load. Its administration to rats causes a decreased rate of glucose utilization by their adipose tissue in vitro. Chlorothiazide added directly to the incubating medium also decreases the rate of glucose utilization of rat adipose tissue.
Weller, John M., Borondy, Paul E.
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In Silico Drug Design of Benzothiadiazine Derivatives Interacting with Phospholipid Cell Membranes. [PDF]
Membranes (Basel), 2022 The use of drugs derived from benzothiadiazine, a bicyclic heterocyclic benzene derivative, has become a widespread treatment for diseases such as hypertension, low blood sugar or the human immunodeficiency virus, among others.
Hu Z, Marti J.
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Chlorinated benzothiadiazines inhibit angiogenesis through suppression of VEGFR2 phosphorylation. [PDF]
Bioorg Med Chem, 2022 Huwaimel BI +7 more
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THE EFFECT OF BENZOTHIADIAZINE DIURETICS ON THE RENAL CONCENTRATING MECHANISM OF THE SHEEP [PDF]
Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1966 The effects of an infusion of vasopressin (40 m. U. I. V.) were studied in conscious sheep. Vasopressin caused consistent increases in urinary total solute and K output and variable increases in Na and Cl excretion. Vasopressin always increased water reabsorption relative to solute reabsorption, although an antidiuresis did not occur when the initial ...
Cross R.B., Thornton W.M.
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Discovery of Halogenated Benzothiadiazine Derivatives with Anticancer Activity** [PDF]
ChemMedChem, 2020 AbstractMitochondrial respiratory complex II (CII), also known as succinate dehydrogenase, plays a critical role in mitochondrial metabolism. Known but low potency CII inhibitors are selectively cytotoxic to cancer cells including the benzothiadiazine‐based anti‐hypoglycemic diazoxide.
Bader I. Huwaimel +7 more
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Anti-HIV-1 Activity of Benzothiadiazine Dioxide [PDF]
Antiviral Chemistry and Chemotherapy, 2001 Antiviral assays carried out on the potent benzothiadiazine dioxide (BTD) human cytomegalovirus (HCMV) inhibitors have led us to find marginal but selective anti-HIV-1 activity. Specific pharmacological studies, such as time of addition experiments and assays on specific viral strains with mutations on its reverse transcriptase, have indicated that ...
Martinez, A. +7 more
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A short, versatile route towards benzothiadiazinyl radicals. [PDF]
Chem Sci, 2021 Borys AM +4 more
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In silico identification of promising inhibitor against RNA-dependent RNA polymerase target of SARS-CoV-2. [PDF]
Mol Biol Res Commun, 2021 Singh P +4 more
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BTDAzo: A Photoswitchable TRPC5 Channel Activator. [PDF]
Angew Chem Int Ed Engl, 2022 Müller M +7 more
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