BTDAzo: A Photoswitchable TRPC5 Channel Activator. [PDF]
Angew Chem Int Ed Engl, 2022 Photoswitchable reagents can be powerful tools for high-precision biological control. TRPC5 is a Ca2+-permeable cation channel with distinct tissue-specific roles, from synaptic function to hormone regulation.
Müller M +7 more
europepmc +5 more sources
A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A. [PDF]
PLoS ONE, 2011 RNA synthesis by the genotype 1b hepatitis C virus (HCV) polymerase (NS5B) transiently expressed in Human embryonic kidney 293T cells or liver hepatocytes was found to robustly stimulate RIG-I-dependent luciferase production from the interferon β ...
C T Ranjith-Kumar +4 more
doaj +9 more sources
Anti-HIV-1 Activity of Benzothiadiazine Dioxide [PDF]
Antiviral Chemistry and Chemotherapy, 2001 Antiviral assays carried out on the potent benzothiadiazine dioxide (BTD) human cytomegalovirus (HCMV) inhibitors have led us to find marginal but selective anti-HIV-1 activity. Specific pharmacological studies, such as time of addition experiments and assays on specific viral strains with mutations on its reverse transcriptase, have indicated that ...
Martinez, A. +7 more
core +6 more sources
In Silico Drug Design of Benzothiadiazine Derivatives Interacting with Phospholipid Cell Membranes [PDF]
Membranes, 2022 The use of drugs derived from benzothiadiazine, a bicyclic heterocyclic benzene derivative, has become a widespread treatment for diseases such as hypertension, low blood sugar or the human immunodeficiency virus, among others.
Zheyao Hu, Jordi Marti
doaj +2 more sources
A short, versatile route towards benzothiadiazinyl radicals. [PDF]
Chem Sci, 2021 A family of substituted 1,2,4-benzothiadiazine 1-chlorides have been prepared by treatment of N-arylamidines in neat thionyl chloride at reflux. The S(IV) 1-chlorides are readily reduced under mild conditions to persistent 1,2,4- benzothiadiazinyl ...
Borys AM +4 more
europepmc +3 more sources
Molecular modeling studies, synthesis, configurational stability and biological activity of 8-chloro-2,3,5,6-tetrahydro-3,6-dimethyl-pyrrolo[1,2,3-de]-1,2,4-benzothiadiazine 1,1-dioxide [PDF]
, 2011 The potential therapeutic benefit of compounds able to activate AMPA receptors (AMPArs) has led to a search for new AMPAr positive modulators. Among them, 8-chloro-2,3,5,6-tetrahydro-3,6-dimethyl-pyrrolo[1,2,3-de]-1,2,4-benzothiadiazine 1,1-dioxide (1 ...
Umberto Maria Battisti +7 more
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Chlorinated benzothiadiazines inhibit angiogenesis through suppression of VEGFR2 phosphorylation. [PDF]
Bioorg Med Chem, 2022 Huwaimel BI +7 more
europepmc +3 more sources
COMBINATORIAL PHARMACOPHORE MODELING AND ATOM BASED 3D QSAR STUDIES OF BENZOTHIADIAZINES AS HCV-NS5B INHIBITORS [PDF]
, 2018 Objective: The objective of the current study was to elucidate the 3D pharmacophoric features of benzothiadiazine derivatives that are crucial for inhibiting Hepatitis C virus (HCV) Non-structural protein 5B (NS5B) and quantifying the features by ...
Prasanthi Polamreddy +2 more
openalex +4 more sources
The Antihypertensive Actions of Benzothiadiazines [PDF]
Circulation, 1961 Bertram M. Winer
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Effects of benzothiadiazine drugs on carbohydrate metabolism [PDF]
Metabolism, 1965 Abstract The administration of chlorothiazide both to man and to rats results in hyperglycemia following a glucose load. Its administration to rats causes a decreased rate of glucose utilization by their adipose tissue in vitro. Chlorothiazide added directly to the incubating medium also decreases the rate of glucose utilization of rat adipose tissue.
Weller, John M., Borondy, Paul E.
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