Results 61 to 70 of about 1,407 (189)

Phenacyl Bromide: An Organic Intermediate for Synthesis of Five- and Six-Membered Bioactive Heterocycles [PDF]

, 2019
An environmentally friendly, economic synthetic protocol was advanced for synthesis of biologically and pharmacologically vital five- and six-membered heterocycles containing nitrogen, sulphur and oxygen as heteroatom.
Dhadda, Surbhi, Jangid, Dinesh Kumar
core   +2 more sources

3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach

Pharmaceuticals, 2016
The liver enzyme matriptase-2 is a multi-domain, transmembrane serine protease with an extracellular, C-terminal catalytic domain. Synthetic low-molecular weight inhibitors of matriptase-2 have potential as therapeutics to treat iron overload syndromes ...
Polya G. Roydeva, Anna-Madeleine Beckmann, Marit Stirnberg, Jožko Cesar, Danijel Kikelj, Janez Ilaš, Michael Gütschow   +6 more
doaj   +1 more source

Solid‐Phase Synthesis of 1,3,5,6‐Tetra‐Substituted 3,5‐Dihydroimidazo[4,5‐c][1,2]Thiazin‐4(1 H)‐One 2,2‐Dioxide Derivatives

Journal of Heterocyclic Chemistry, Volume 62, Issue 9, Page 938-943, September 2025.
Through an efficient solid‐phase synthesis method, 32 different 1,3,5,6‐tetra‐substituted 3,5‐dihydroimidazo[4,5‐c][1,2]thiazin‐4(1H)‐one 2,2‐dioxide derivatives were synthesized. The derivative library, with a total of four diversities, showed an overall yield of 7%–32% over 8 steps.
Jimin Moon, Hyojin Lee, Sohee Kim, Taeho Lee   +3 more
wiley   +1 more source

Új szintézismódszerek kidolgozása és alkalmazása célzott hatásterületen aktív heterociklusos molekulák szintézisére = Elaboration and application of new synthetic methodologies for the synthesis of heterocyclic molecules of aimed biological activity [PDF]

, 2013
Pályázati kutatásunk alapvető célja az volt, hogy néhány, a legutóbbi időkben felismert új szintézis-lehetőséget laboratóriumunkban meghonosítsunk, saját magunk új módszereket dolgozzunk ki, és mindezek segítségével felfedező kutatásokat végezzünk ...
Gömöry, Ágnes, Hajós, György, Horváth, Dániel Vajk, Jakus, Judit, Jemnitz, Katalin, Lejtoviczné Egyed, Orsolya, Lois, Isabella, Mehdi, Hasan, Palkó, Roberta, Pápai, Imre, Riedl, Zsuzsanna, Rokob, Tibor András, Soós, Tibor, Szigeti, Marianna, Takács, Daniella, Váradi, Linda   +15 more
core  

Synthesis, Antimycobacterial Activity, and Computational Insight of Novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates against Multidrug‐Resistant Mycobacterium Tuberculosis

ChemMedChem, Volume 20, Issue 14, July 18, 2025.
A series of 14 novel 1,4‐benzoxazinone derivatives is tested against various strains of Mycobacterium tuberculosis. All compounds show high activity against all tested strains, particularly the resistant strains. Additionally, the novel derivatives exhibit low cytotoxicity toward mammalian Vero cells.
Maria Grazia Mamolo, Emanuele Carosati, Diletta Pasin, Alessandro De Logu, Gianluigi Cabiddu, Marko Jukič, Daniele Zampieri   +6 more
wiley   +1 more source

2H-Benzo[1,4]thiazin-3-one Derivatives Endowed with Antifungal Activity [PDF]

, 2018
The in vitro susceptibility tests with terbinafine and fluconazole, using the CLSI methodology were described to evaluate the 2H-benzo[1,4]thiazin-3-one derivatives. All compounds synthesized were investigated in vitro against Candida spp.
Andrade, Juliana Luisa Teixeira de, Barros, Elisabete Silva, Guarda, Vera Lucia de Miranda, Ruela, Fernando Armini, Sá, Nathalia Duarte de   +4 more
core   +2 more sources

Reaction of 1,2-Diaza-1,3-butadienes with thiol derivates: a versatile construction of nitrogen/sulfur containing heterocycles [PDF]

, 2015
none9sìopenATTANASI O.A.; FILIPPONE P; LILLINI S; NICOLINI S; MANTELLINI F; APARICIO D; IGNACIO R; DE LOS SANTOS J.M; PALACIOS FAttanasi, ORAZIO ANTONIO; Filippone, Paolino; Lillini, S; Nicolini, Simona; Mantellini, Fabio; Aparicio, D; Ignacio, R; DE LOS

core   +1 more source

Synthetic approaches to 2-aryl/hetaryl- and 2-(hetaryl)ylidene derivatives of fluorinated 1,3-benzothiazin-4-ones [PDF]

, 2020
A series of 2-hetaryl- and 2-(hetaryl)ylidene substituted 5-fluoro-8-nitro-1,3-benzothiazin-4-ones was synthesized by interaction of 2,6-difluoro-3-nitrobenzoylisothiocyanate with C-nucleophiles.
Batanova, Olga A., Lipunova, Galina N., Mochulskaya, Nataliya N., Nosova, Emiliya V.   +3 more
core   +3 more sources

Hydrophobic interaction of 2-trifluoromethyl-N 10-substituted phenoxazines with bovine serum albumin and reversal of drug resistance in bacterial cells [PDF]

, 2015
Objective: The objective of this study was to report the hydrophobic interaction of 2-trifluoromethyl-N10 Methods: Binding of six compounds, 10-3-substituted phenoxazines with bovine serum albumin and reversal of drug resistance in bacterial cells.
Eregowda, G.B., Kumara, M.N., Padma, T., Rangappa, K.S., Sridhar, B.T., Thimmaiah, K.N.   +5 more
core  

N-(2,3-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

Acta Crystallographica Section E, 2009
In the crystal structure of the title compound, C18H18N2O4S, the thiazine ring adopts a distorted half-chair conformation. 1,2-Benzothiazines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of ...
doaj   +1 more source