Results 51 to 60 of about 1,143 (191)

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach

Pharmaceuticals, 2016
The liver enzyme matriptase-2 is a multi-domain, transmembrane serine protease with an extracellular, C-terminal catalytic domain. Synthetic low-molecular weight inhibitors of matriptase-2 have potential as therapeutics to treat iron overload syndromes ...
Polya G. Roydeva, Anna-Madeleine Beckmann, Marit Stirnberg, Jožko Cesar, Danijel Kikelj, Janez Ilaš, Michael Gütschow   +6 more
doaj   +1 more source

Cutaneous Photoaging: A Review of Melasma and Nanotechnological Approaches to Its Control

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Skin is a complex tissue that performs important functions to protect the body against environmental stressors and also synthesizes melanin, a pigment essential for preventing keratinocyte DNA from UV‐induced damage. Excessive solar radiation triggers skin photoaging, leading to hyperactivation of melanocytes and the development of melasma on the face.
Daniela Mayra de Oliveira Figueiredo, Mateus Freire Leite, Suraiya Saleem   +2 more
wiley   +1 more source

2‐Phenyl‐1,2,6,7‐Tetrahydrocyclopenta[D][1,3]Thiazine‐4(5H)‐Thione: Synthesis, Crystal Structure, Hirshfeld Surface Analysis, DFT Calculations, ADMET Prediction, and Molecular Docking†

Journal of Chemistry, Volume 2026, Issue 1, 2026.
The compound 2‐phenyl‐1,2,6,7‐tetrahydrocyclopenta[d][1,3]thiazine‐4(5H)‐thione (I) was synthesized from benzylideneaniline and 2‐amino‐1‐cyclopentene‐dithiocarboxylic acid. Its molecular structure was confirmed by FT‐IR and NMR spectroscopy, and the crystalline phase was verified by powder X‐ray diffraction.
Gerzon E. Delgado, Jonathan Cisterna, Carla Coy, Asiloé J. Mora, Marilia Guillen, Edward Ávila, Ricardo R. Contreras, Cecilia Chacón, Gustavo Marroquin, Gerson Márquez, Munmun Bardhan   +10 more
wiley   +1 more source

A one-step synthesis of 2,3-dihydro-1,4-benzothiazines and phenothiazines from 1,3-thiazolidine derivatives of cyclohexanones R. Caputo; C. Ferreri; L. Longobardo; D. Mastroianni; G. Palumbo; S. Pedatella

, 1993
N-Acetyl-1,3-thiazolidine derivatives of cyclohexanones, when treated with a threefold excess N-bromosuccinimide in anhydrous chloroform at room temperature, smoothly afford N-acetyl-2,3-dihydro-1,4-benzothiazines. This represents the first general route
PALUMBO, GIOVANNI, S. Pedatella, L. Longobardo, R. Caputo, C. Ferreri, D. Mastroianni, Silvana Pedatella, Romualdo Caputo, Domenico Mastroianni, Luigi Longobardo, Carla Ferreri, Giovanni Palumbo   +11 more
core   +1 more source

Evaluation of a New Riluzole‐Based Compound VA945 on Sodium and Potassium Conductances Expressed by SH‐SY5Y‐ Derived Neurons

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
The potential capability of a newly synthesized riluzole‐based compound, VA945, to affect neuronal excitability was tested by assessing its ability to modulate the biophysical properties of voltage‐gated sodium (Nav) and Delayed‐Rectifier Potassium (KDR) channels expressed in SH‐SY5Y human neuroblastoma cells differentiated into neurons.
J. Cazzola, F. Talpo, G. Faravelli, C. Donati, S. Maramai, M. Saletti, G. Giuliani, M. Paolino, A. Cappelli, M. Anzini, P. Sommi, A. Vitali, A. Sala, A. Trucco, G. R. Biella, P. Spaiardi   +15 more
wiley   +1 more source

Modellierung von Neuromelanin des Mittelhirns und Hirnstamms zur Charakterisierung der Metallbindung und des damit verbundenen MRT‐Kontrasts bei der Parkinson‐ und Alzheimer‐Krankheit

Angewandte Chemie, Volume 137, Issue 41, October 6, 2025.
Synthetische Neuromelanin‐Analoga werden verwendet, um die Bindung von Eisen und Kupfer an die Melaninkomponente oder an konjugiertes Protein (β‐Lactoglobulin) zu charakterisieren. Die Modelle bestätigen das Vorhandensein paramagnetischer mononuklearer Bindungsstellen und von Clustern aus aggregiertem Eisen oder gemischten Metalltypen, die jeweils die ...
Niklas Wallstein, Andrea Capucciati, Andreas Pöppl, Claudia S. Schnohr, Michela Sturini, André Pampel, Carsten Jäger, Luigi Zecca, Fabio A. Zucca, Enrico Monzani, Luigi Casella, Harald E. Möller   +11 more
wiley   +1 more source

α-Chloroketones enabled Rh(III)-catalyzed enantioselective C–H [4+2] annulation of sulfoximines under mild and redox-neutral conditions

Green Synthesis and Catalysis
Taking advantage of facilely available α-chloroketones as C(sp3)-based electrophilic partners and oxidized alkyne equivalents, we here present a novel CpxRh(III)-catalyzed enantioselective C–H [4 ​+ ​2] annulation of sulfoximines under mild and redox ...
Qingwei Song, Wenhao Wu, Weijie Chen, Hui Gao, Zhi Zhou, Zhongyi Zeng, Wei Yi   +6 more
doaj   +1 more source

Modeling Midbrain and Brainstem Neuromelanins to Characterize Metal Binding and Associated MRI Contrast in Parkinson's and Alzheimer's Diseases

Angewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.
Synthetic neuromelanin analogs are used to characterize iron and copper binding to the melanin moiety or to conjugated protein (β‐lactoglobulin). The models confirm the presence of paramagnetic mononuclear‐binding sites and iron or mixed‐metal clusters that enhance water proton relaxation to varying degrees.
Niklas Wallstein, Andrea Capucciati, Andreas Pöppl, Claudia S. Schnohr, Michela Sturini, André Pampel, Carsten Jäger, Luigi Zecca, Fabio A. Zucca, Enrico Monzani, Luigi Casella, Harald E. Möller   +11 more
wiley   +1 more source

Intramolecular sulfenylation using sulfoxides. preparation of 5H-pyrrolo[1,2-a][3,1]benzothiazines

, 1994
N-[2-(Phenylsulfinylmethyl)phenyl]pyrrole (4) undergoes transfer sulfenylation to N-(2-chloromethylphenyl)-2-phenylthiopyrrole (5′) presumably via S-phenyl 5H-pyrrolo[1,2-a][3,1]benzothiazonium chloride (7).
Picard, Joseph A., J. A. PICARD, S. CHEN, Bates, Dallas K., D. K. BATES, Chen, Shaowu, Shaowu Chen, Dallas K. Bates, Joseph A. Picard   +8 more
core   +1 more source